European Journal of Clinical and Experimental Medicine T.22, z. 1 (2024)


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  • Pozycja
    Total resection of foramen magnum meningioma via a far-lateral approach – a case report
    (Publishing Office of the University of Rzeszow, 2024-03) Szymoniuk, Michał; Sakw, Leon; Domagalski, Łukasz; Gałązka, Jakub Krzysztof; Hoffman, Zofia; Dryla, Aleksandra; Czyżewski, Wojciech; Szczepanek, Dariusz; Torres, Kamil; Rola, Radosław
    Introduction and aim. The foramen magnum is a rare location of meningioma development, accounting for 1.8 to 3.2% of all reported tumors of this type. Microsurgical resection, representing a gold standard in foramen magnum meningioma treat ment, may result in various neurological deficits or incomplete resection due to challenging anatomical conditions. Currently, even surgical resections of foramen magnum meningioma conducted by experienced neurosurgeons are burdened by a relatively high complication rate of 17.2% Description of the case. We report the case of a 25-year-old male who presented increasing headaches and decreasing activity for 5 months. In his medical history, the patient had been diagnosed with cerebral palsy, autism spectrum disorder, and suffered partial seizures. Magnetic resonance imaging revealed anterolateral foramen magnum meningioma. The tumor was resected via a far-lateral approach. After the surgery, the patient maintained a preoperative neurological state without additional neurological deficits. The post-operative magnetic resonance imaging demonstrated complete tumor removal. Histopatholog ical examination revealed transitional meningioma (WHO grade I). Conclusion. Our case demonstrates that the far-lateral approach can be efficient for the resection of anterolateral foramen magnum meningioma. In such cases, Simpson grade 1 can be achieved without complications, providing immediate relief of symptoms and minimizing the risk of recurrence.
  • Pozycja
    Water-related diseases following flooding in South Asian countries – a healthcare crisis
    (Publishing Office of the University of Rzeszow, 2024-03) Ahmed, Syed Hassan; Shaikh, Taha Gul; Waseem, Summaiyya; Zahid, Maha; Mohamed Ahmed, Khabab Abbasher Hussien; Ullah, Irfan; Hasibuzzaman, Md Al
    Introduction and aim. Industrialization and elevated greenhouse gas emissions pose significant threats to the environment, raising atmospheric carbon dioxide levels and leading to climate change. Climate change may impact human health either directly via increasing extreme weather frequency and altering disease patterns or indirectly via social institutions and disrupted global supply chain resulting in consequences like undernutrition Material and methods. This review conducted a comprehensive literature search on PubMed, Google Scholar, and Cochrane Library, from inception to September 2022, using relevant keywords. Analysis of the literature. Massive flooding in South Asia is leading to a surge in water-related diseases. Cholera outbreaks have occurred in countries like Pakistan, India, and Bangladesh following floods, and waterborne diseases like typhoid, rota virus, hepatitis A, and leptospirosis are prevalent in flood-affected regions. Additionally, Cryptosporidium, Campylobacter, Shigella, and Polio outbreaks are reported. Water-scarce diseases, including scabies, impetigo, and cellulitis, are also on the rise in flood-affected areas. Water-based diseases, such as dracunculiasis, schistosomiasis, and Leishmaniasis, pose significant risks. Vector-borne diseases, including malaria, dengue, and Leishmaniasis, are becoming more prevalent due to flooded areas providing breeding grounds for disease vectors like mosquitoes and sandflies. These diseases are now more common in flood-af fected regions, affecting millions of people. Conclusion. Urgent measures are needed, including early warning systems, resilient infrastructure, drainage maintenance, and stricter land-use regulations, to reduce the impact of these natural disasters. International cooperation and immediate action at national and global levels are essential to mitigate the health crises caused by flooding and other natural disasters.
  • Pozycja
    Prolonged screen-time as the cause of ocular disorders: what can we do with the problem? – a review
    (Publishing Office of the University of Rzeszow, 2024-03) Dyrek, Martyna; Sikorska, Ewa; Partyka, Aleksandra; Sikorski, Piotr; Dusza, Edyta; Kopacz, Dorota
    Introduction and aim. Recently, an increased use of video display terminals has been observed in workplace environments, as a result of the evolution of communication technologies and new information-sharing strategies. It has led to an increased prevalence of computer-related ocular disorders, such as computer vision syndrome, dry eye disease, refractive errors and con vergence insufficiency. In this review we describe problems associated with these disorders and propose preventive methods. Material and methods. With the use of specific keywords, the databases of the PubMed, Science Direct, and Google Scholar were searched for relevant original papers. Analysis of the literature. The listed disorders might have similar symptoms, such as eye burning, itching, blurred vision, and tearing, and their severity correlates with the time of exposure to video display units. However, there are preventive measures, which can help in decreasing the negative effects of computers on our vision, such as adequate viewing distance, proper work space lighting, eyeglasses with anti-glare coating, taking 5-minutes breaks after every 30 minutes, or following the 20-20-20 rule. Conclusion. Prolonged usage of the video display terminals is connected to many ocular disorders, and in today’s world, it is very important to remember actions that can be undertaken to minimize the risk.
  • Pozycja
    PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
    (Publishing Office of the University of Rzeszow, 2024-03) Ruffini, Livia; Zilioli, Alessandro; Cervati, Veronica; Lauretan, Fulvio; Misirocchi, Francesco; Maggio, Marcello; Migliari, Silvia; Graziani, Tiziano; Cidda, Carla; Baldari, Giorgio; Spallazzi, Marco; Scarlattei, Maura
    Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone or confound the final diagnosis. Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands provide target-specific information and may anticipate the diagnosis by “in vivo” detection of the neuro pathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion or tau inclusions. This concise review will dis cuss the potential of PET and SPECT imaging as a solid guide to better characterize atypical phenotypes of neurodegeneration in the clinical routine, with the potential to drive personalized interventions, improve cohort uniformity for clinical trials, and serve as biomarkers for targeted molecular therapies. Material and methods. Literature search was performed focusing on the role of PET and SPECT imaging in assessing atypical phenotypes of neurodegeneration, using the electronic source of database PubMed/MEDLINE and the web-based search engines Google, Google Scholar. Analysis of the literature. New disease-modifying drugs may increase their effect with early initiation, which is especially im portant in working persons and younger subjects presenting atypical symptoms. In older individuals, the coexistence of neu rodegeneration, age-related changes, cerebrovascular lesions, or depression makes challenging a definitive diagnosis. Quantitative tools able to measure tracer distribution increase the accuracy of molecular neuroimaging creating topographic maps that compare subject’s data with healthy controls databases. Conclusion. Atypical phenotypes may be associated with quantitative key-pattern allowing a more precise and early diagnosis of the neurodegenerative disorder. Finally, quantitative assessment of the pathological substrates allows us to track the disease process and measure treatment response.
  • Pozycja
    The benefits and limitations of using blue-blocking filters – a review of results of clinical trials
    (Publishing Office of the University of Rzeszow, 2024-03) Partyka, Aleksandra; Dyrek, Martyna; Sikorski, Piotr; Sikorska, Ewa
    Introduction and aim. Blue light is part of the natural light spectrum and plays a role in regulating the circadian rhythm. However, with the increasing use of electronic devices and energy-efficient lighting emitting high levels of artificial blue light, concerns are raised regarding its potential effect on human health. Blue-blocking filters have been developed and are adver tised as a solution to be used in spectacles or intraocular lenses. This review aims to provide an in-depth analysis of the use of blue-blocking filters based on the results of clinical trials. Material and methods. This review included relevant original papers reporting on clinical trial results from PubMed, Science Direct, and Google Scholar databases using specified keywords. Analysis of the literature. Trials conducted with patients reveal mixed results, with some showing no significant changes in vision and reading abilities, while others indicating potential limitations such as reduced contrast vision. However, blue-blocking filters have demonstrated potential benefits in improving sleep quality and mood, particularly in patients with sleep disturbances or psychiatric disorders. The efficacy of blue-blocking filters in mitigating symptoms of digital eye strain remains inconclusive. Conclusion. Overall, this paper provides a comprehensive assessment of the benefits and limitations associated with the use of blue-blocking filters, highlighting the need for further investigation in certain areas.