European Journal of Clinical and Experimental Medicine T.22, z. 1 (2024)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/10350

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Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes
(Publishing Office of the University of Rzeszow, 2024-03) Mishra, Purti; Sethi, Pooja; Ramasamy, Selva Kumar; Saini, Adesh K.; Tuli, Hardeep Singh; Mittal, Divya; Trehan, Aarti
Introduction and aim. At present, several microbial diseases are prominent and of concern worldwide. The intent of this study was to examine the antibacterial potential of newly synthesized tetradentate macrocyclic complexes against different bacte rial strains. The macrocyclic scaffold has gained attention as a biologically active class of supramolecular chemistry due to its unique properties and ability to target various microorganisms. Thus, the goal of the present study was to develop a series of biologically active transition metal-based macrocycles. Material and methods. All macrocyclic compounds were synthesized by a template method and validated by molar conductiv ity, elemental studies, and spectral and magnetic studies. Antibacterial activities of all metal complexes were evaluated against Escherichia coli (MTCC 739) and Staphylococcus aureus (MTCC 731) bacterial strains by taking ampicillin as a standard reference drug. DNA photocleavage potential was explored using agarose gel electrophoresis. Results. Results revealed the formation of novel macrocyclic complexes via tetra nitrogen bond trapping of metals. Copper complexes have strong potential against S. aureus bacteria as copper and nickel both show good DNA photocleavage potential. Conclusion. The findings endorse the biomedical relevance of these macrocyclic scaffolds, suggesting avenues for further exploration in targeted drug delivery and potential clinical applications. The proposed octahedral geometry for the complexes enhances our understanding of their structural aspects. This research contributes substantively to the field, laying the foundation for future investigations in advanced antimicrobial design and application.
Assessment of hepatorenal biochemical indices in male Sprague Dawley rats preceding concurrent oral administration of Ghana alcoholic bitters and natural cocoa powder
(Publishing Office of the University of Rzeszow, 2024) Maalman, Raymond Saa-Eru; Bimpong, Samuel; Abaidoo, Chrissie Stansie; Cuba, Magalys Lopez; Kumi, Michael Barima; Sarkodie, Francis Kofi
Introduction and aim. There has been a surge in the consumption of Ghanaian alcoholic bitters. Ghanaian alcoholic bitters are formulated from a maceration of not less than three plant parts making the organic composition very complex. There appear to be no studies on the effect of Ghanaian alcoholic bitters on the hepatorenal biochemistry indices. The study aimed to assess the effects of alcoholic bitters and cocoa powder on the liver and kidney serum biochemistry. Material and methods. Twenty-four healthy male Sprague Dawley rats, age 11–12 weeks, weighing 150–250 g were used. The rats were randomly assigned to four groups (n=6). At the end of the experimentation, a blood sample was taken by cardiac puncture and centrifuged to obtain the serum for biochemical assays and analysis. Results. The liver enzymes showed no significant difference between the treatment and control groups. There were higher mean values for total bilirubin and direct bilirubin for alcoholic bitters and natural cocoa powder groups respectively than the control group and the co-administration of alcoholic bitters and natural cocoa powder group. Conclusion. The study concludes that alcoholic bitters consumption might cause injury to the liver and kidney resulting in anomaly of the hepatorenal indices from rat blood serum biochemistry.
Assessment of preoperative anxiety and negative automatic thoughts in patients waiting for corneal transplantation
(Publishing Office of the University of Rzeszow, 2024-03) Tanrıverdi, Seher; Şen, Mehmet Ali; Genç, Hasan
Introduction and aim. In patients waiting for organ transplantation, increased waiting time can increase anxiety by creating negative automatic thoughts. The aim of this study is to examine the relationship between corneal transplant recipients’ negative automatic thoughts and anxiety before organ transplantation. Material and methods. The population of this correlational descriptive study consisted of 108 patients waiting for cornea transplantation in the Eye Bank unit of a hospital in the south east region of Türkiye. The data were obtained from the patients presented to the ophthalmology clinic for transplantation between September and December 2022. A patient information form, the Negative Automatic Thoughts Scale, and the Trait Anxiety Scale were used to collect the data. Percentage distribution, arithmetic mean, logistic regression and correlation analysis were used in the data analysis. Results. It was determined that the mean score of the negative automatic thoughts of the transplant patients participating in the study was 100.69±47.83, and the trait anxiety mean score was 53.06±6.07. There was a positive relationship between neg ative automatic thoughts and trait anxiety at a moderate level, which was statistically significant (p<0.05, r=0.53). Conclusion. It was determined in the study that the patients’ negative automatic thoughts and trait anxiety were high, and their anxiety increased as the negative automatic thoughts increased.
Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State
(Publishing Office of the University of Rzeszow, 2024-03) Al-Tayeb, Al-Noor Opied; Abubakr, Mohammed Hayati; Elrheima, Hafsa Ahmed; Habbani, Ahmed Khalid; Elrasul, Rami Y. Hassab
Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group. Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001. Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
Behaviors of pregnant women regarding travel – the case of Türkiye
(Publishing Office of the University of Rzeszow, 2024-03) Erciyas, Şeyma Kilci; Cirban-Ekrem, Ebru; Demir, Rukiye; Aköz, Gizem
Introduction and aim. With the development of transportation facilities and options, people can now travel easily. With women having a greater presence in the workforce, pregnant women can work until the eighth week before childbirth. This study was conducted to examine the behaviors of pregnant women regarding travel. Material and methods. The data for this cross-sectional and descriptive study were collected from 519 pregnant women who voluntarily participated in the research and met the research criteria. The data were analyzed using the SPSS 24 software package. Results. The average age of the participating pregnant women was 27.49±0.17, with 63.8% residing in urban areas, 74.8% be ing primiparous, and 47.6% being in the third trimester of pregnancy. A decrease in travel and car usage during pregnancy. The use of bus, train/tram/metro, taxi, bicycle/scooter, and motorcycle decreased during pregnancy, while use of car, plane, and ship/ferry increased. 81.9% of women always wore a seat belt during pregnancy. There was a statistically significant difference between the educational level of women and their car usage (p<0.005). It was found that women wore seat belts more frequently in the third trimester. As the number of pregnancies increased, the frequency of seat belt usage decreased. Conclusion. A decrease in the frequency of travel was observed among women during pregnancy. The levels of seat belt usage and correct seat belt fastening were unsatisfactory.
Caring and therapeutic services – a patient’s opinion on experience and satisfaction with night nursing care
(Publishing Office of the University of Rzeszow, 2024-03) Fąfara, Anna; Krakowiak-Burdzy, Anna
Introduction and aim. Night nursing care ensures well-being, peace, and security allowing a patient to enter into the deep sleep phase. This study aims to analyze the relationship between an assessment of caring and therapeutic services and the opinion of in-patients on their experience and satisfaction with night nursing care. Material and methods. A questionnaire developed by the authors and the Newcastle Satisfaction with Nursing Scale were used in this study. This study was conducted in the eastern region of Poland in the Podkarpackie province. The study included 585 patients. Results. Tasks analyzed resulting from care and therapeutic functions, in the patient’s opinion, had a significant impact on the overall assessment of nursing care. Meeting the expectations regarding night rest (experience of nursing care) and satisfaction showed the strongest correlation. Tasks resulting from therapeutic functions showed an average correlation with the exception of planned medical care. Conclusion. The level of implemented health services by nurses at night significantly influences the overall assessment of the quality management system in health care.
Comparison of algorithms for detection of active inflammatory lesions in sacroiliitis
(Publishing Office of the University of Rzeszow, 2024-03) Gawłowski, Igor; Ożga, Joanna; Raczko, Agata
Introduction and aim. Artificial intelligence is increasingly being used in the medicine, particularly in radiological diagnosis of diseases such as an axial spondyloarthritis (axSpA). The aim of this study is to compare the available algorithms designed to detect active sacroiliitis in patients with axSpA. Material and methods. Four algorithms, two semi-automated and two full-automated for the assessment of bone marrow ede ma (BME) on magnetic resonance imaging (MRI) of the sacroiliac joints (SIJs) were included in the study. They were described and compared in terms of specificity, sensitivity, and correlation of BME detection findings between AI and experts. Analysis of the literature. Among all automated algorithms, the one created by Bressem et al. had the highest number of ex aminations analyzed in the study, involving 593 MRIs of SIJs. The sensitivity and specificity, as well as the correlation between the AI’s detection of BME versus manual, were not calculated for each algorithm. Rzecki’s algorithm had the greatest sensitivity and specificity for BME detection reaching 0.95 and 0.96, respectively. In addition, its Speraman’s coefficient of correlation be tween manual and automated measurements was 0.866. Conclusion. Each of described algorithms is certainly useful in assessing BME in the MRI examinations of SIJs.
Consensus Committee of experts on Kawasaki Disease and Chinese Journal of Contemporary Pediatrics – the expert consensuses on intravenous immunoglobulin, aspirin, and glucocorticoid
(Publishing Office of the University of Rzeszow, 2024-03) Ren, Shuying; Deng, Fangming; Du, Zhongdong; Yang, Xiaodong; Xie, Lijian; Wang, Hong; Jiao, Fuyong
Introduction and aim. Kawasaki disease (KD) is an acute vasculitis with unknown etiology, usually occurring in chil dren under 5 years old. This article will summarize the three consensuses formulated in China about KD. Material and methods. English databases for consensus search include UpToDate, BMJ Clinical Evidence, National Guideline Clearinghouse, Joanna Briggs Institute Library, Cochrane Library, and PubMed, etc.; Chinese databases in clude China Biomedical Literature Service, China Knowledge Network, Wanfang database, etc. All literature searches ended on February 28, 2022. Analysis of the literature. KD is a common acquired heart disease in children and can lead to severe complications such as coronary injury. However, intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and the first-line treatment to prevent cardiovascular complications. Glucocorticoid (GC) is mainly used for KD patients with a high risk of coronary artery aneurysm (CAA), no immunoglobulin response, and confirmed CAA. There are already consensus guidelines on diagnosing and treat ing KD in different countries. This article summarizes the relevant expert consensus on aspirin, glucocorticoids and IVIG for the treatment of Kawasaki disease in China. Conclusion. Still, there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of medication for KD.
Determinants of distress levels in high-risk pregnant women – cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-03) Kara, Pınar; Nazik, Evşen; Çerçer, Zehra
Introduction and aim. Global and national care recommendations indicate that women with high-risk pregnancies should receive personalized and qualified care during this period. This study was conducted to determine the distress levels in high-risk pregnant women and affecting factors. Material and methods. The cross-sectional this study was conducted with total of 416 high-risk pregnant women who met the inclusion criteria in the obstetrics clinic of a training and research hospital. The study data were collected with data collection form and “Tilburg Pregnancy Distress Scale (TPDS).” Results. The mean TPDS total score of high-risk pregnant women was 18.25±6.85. It was found that planning pregnancy, gravida, and diagnosis of gestational hypertension, systemic diseases, and gestational diabetes in the present pregnancy was asso ciated with pregnancy-specific distress (p<0.05; β=0.291, β=0.158, β=0.272, β=0.137, β=0.116, respectively). Conclusion. It is advised that health professionals assess the distress levels of high-risk pregnant women and give personalized care during prenatal period.
Effect of clinic-based and telemonitored home-based intervention on pain intensity, functioning and quality of life in patients with knee osteoarthritis
(Publishing Office of the University of Rzeszow, 2024-03) Ojoawo, Adesola Ojo; Odesanya, Oluwaseun; Kunuji, Kayode; Mbada, Chidozie Emmanuel; Adedeji, Oluwafemi Olusesan
Introduction and aim. The study assessed and compared the effects of clinic-based and telemonitored home-based interventions on pain intensity, functioning and quality of life in patients with knee osteoarthritis (KOA). Material and methods. Forty-two patients were recruited purposely and randomly allocated into clinic-based (CBG) and telemonitored home-based group (THG) equally. The CBG and THG received isometric exercises to strengthen the quadriceps and hamstring muscles using theraband. THG received the exercise at home they were monitored on phone thrice in a week, while the CBG did the exercise in the hospital. The subjects performed four sets of eight repetitions three days in a week for eight weeks. Pain intensity, functioning and health related quality of life (HRQoL) were assessed at pretreatment, 6th and 8th week of intervention. Data was analyzed with descriptive and inferential statistics. Alpha level was set at 0.05. Results. There was a significant reduction (p<0.001) among pre-treatment, 6th and 8th week intervention in pain intensity, functional pain intensity and quality of life of CBG and THG. CBG showed significant reduction (p<0.001) in pain intensity, function and increase in HRQoL than THG at 8th week. Conclusion. Clinic-based and telemonitored home-based interventions were both effective in the management of KOA but clinic-based intervention was better than telemonitored home-based intervention.
Exploring barriers to vasectomy adoption among married men in Dadra and Nagar Haveli
(Publishing Office of the University of Rzeszow, 2024-03) Patel, Ronak Dhirubhai; Dabhelker, Monika M.; Patel, Priya Mahendrabhai; Solanki, Preeti
Introduction and aim. Vasectomy was introduced in India in 1992 and is the most effective, simple, and safe permanent method of contraception yet its use is very limited among the population. The study’s objectives were to assess the knowledge, attitude, and perception towards vasectomy and the barriers to adoption among married men in Dadra and Nagar Haveli. Material and methods. A cross-sectional hospital-based study was conducted on married male attendants of patients and data were collected on sociodemographic details, knowledge regarding vasectomy, their attitude and perceptions towards vasec tomy, and their intention of using vasectomy in the future. Results. Out of 300 participants, 258 (86%) participants have heard of vasectomy as a contraceptive method, and only one participant has undergone vasectomy. The majority (285; 95%) of the participants agreed that family planning is also a responsi bility of males while nearly two-third (185; 61.7%) of them were not willing to undergo vasectomy in the future. Procedure-re lated factors, post-procedure-related factors, social factors, availability of alternate contraceptive methods, and preference for tubectomy were the barriers to the adoption of vasectomy. Conclusion. There is a need to provide correct information and counseling about vasectomy and non-scalpel vasectomy to eligible couples to increase the acceptance of vasectomy as a safe, effective, and cheaper method of contraception.
Expression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parameters
(Publishing Office of the University of Rzeszow, 2024-03) Panigrahi, Ranjita; Jha, Narendra Kumar; Hota, Subhransu Kumar
Introduction and aim. Angiogenesis, which is accomplished by capillary sprouting, is the process by which new vessels are created from pre-existing ones. In tumor, once their initial blood supply is depleted, a tumour is unable to grow without additional blood flow. Additionally, a tumor’s microvasculature, or microvessel density (MVD), increases along with its capacity to produce angiogenesis. We aimed to observe the relationship between the expression of vascular endothelial growth factor (VEGF) and MVD (using CD34) in oral squamous cell carcinoma (OSCC). Material and methods. The expression of VEGF and CD34 antibodies was analysed using immunohistochemistry method on 50 cases of histopathologically proved OSCC. The expression was correlated with clinicopathological parameters. Results. A significant correlation was observed between VEGF expression and gender, LVSI. No correlation between any other factors and the difference in VEGF expression was statistically significant. Similarly, the MVD expression was not found to be statistically significant in any of the pathological parameters. Conclusion. VEGF positivity as well as MVD were found to be independent of the tumor pathology. Tumor MVD was found to be independent of the expression of VEGF. Further studies in a larger study group may establish a significant association so that antiangiogenic targeted therapy may be initiated.
Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study
(Publishing Office of the University of Rzeszow, 2024-03) Stepanova, Natalia; Rysyev, Andriy; Snisar, Lyudmyla
Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the rela tionship between preexisting dialysis dose, measured by single pool Kt/V (spKt/V), and long-term outcomes of COVID-19 in patients undergoing HD. Material and methods. Demographic, clinical, and laboratory parameters following COVID-19 recovery, and long-term out comes, including the presence of COVID-19 sequelae, hospitalization, and all-cause mortality during a year after COVID-19 were retrospectively analyzed. Results. Out of the 195 patients included, there were 108 males (55.4%) and 87 females (44.6%), with a median age of 56 (44-63) years and a dialysis duration of 49 (31.3–85.2) months. Patients with spKt/V<1.4 had a significantly increased risk of long-term COVID-19 sequelae (HR 9.1, 95% CI: 3.4; 24.6), hospitalization (HR 7.6, 95% CI: 3.9; 14.6), and all-cause mortality (HR 8.5, 95% CI: 2.9; 25.8) within one year after COVID-19 recovery compared with those with spKt/V≥1.4. spKt/V cutoff point of ≤1.3 emerged as a significant risk factor for one-year hospitalization and mortality within our cohort. Conclusion. Suboptimal dialysis dose, as indicated by spKt/V < 1.4, is associated with adverse long-term COVID-19 outcomes in patients undergoing HD. Optimizing dialysis adequacy may mitigate these risks. Further research is needed to validate these f indings and explore interventions to improve outcomes in this vulnerable population.
Identification of Brucella melitensis from camel’s blood by vitek2 and real time polymerase chain reaction
(Publishing Office of the University of Rzeszow, 2024-03) Manivannan, Kavitha; Ramasamy, Malathi; Sundaresan, Uma; Moustafa, Samar M.; Sherloumay; Mariyam, Safna
Introduction and aim. Brucellosis is a zoonotic disease. Experimental clinical and laboratory diagnosis is still facing problems in identifying the organism. The present study will diagnose a Brucella infection in camel blood in Qatar using serological assays. Isolation and identification were performed on a camel blood sample. Brucella in bacterial isolates was determined by real-time polymerase chain reaction (RT-PCR) as a gold standard test. Material and methods. A total of 220 samples, 200 random serum samples, and 20 EDTA blood samples were selected among the above-mentioned random samples, and 20 serum samples from camel handlers were collected from Al Shahaniya prov ince, Qatar. The Rose Bengal test (RBT), buffered antigen plate agglutination test (BAPAT), and enzyme linked immunosorbent assay (cELISA) for the monoclonal antibody in serum samples were performed using commercially available kits. For the molecular detection of Brucella, conventional PCR and real-time PCR (GPS kit) were used for the genus-specific insertion sequence IS711. Brucella melitensis (MICROBOSS Hightech GmbH kit) was used to identify subspecies. Results. The results identified by vitek2 compact (30%) showed B. melitensis in 6 samples out of 20 isolates. Both conventional (66.67%) and RT-PCR (83.33%) analyses supported this, demonstrating the presence of Brucella. These tests also showed that Brucella species were present in Rose Bengal 182/200 (91%), BAPAT 182/200 (91%), and cELISA (90%) 180/200 in camel serum. Conclusion. To conclude, the prevalence of brucellosis in dromedary camels is higher in this region, and as a matter of urgency, measures should be taken to control the disease.
Paroxysmal non-epileptic events vs epilepsy – what we know and where we are in medicine?
(Publishing Office of the University of Rzeszow, 2024-03) Syzdoł, Bartłomiej; Ziółkiewicz, Aleksandra; Sielwanowska, Wiktoria; Żybowska, Monika; Wilczek, Natalia; Szukała,Klaudia; Chrościńska-Krawczyk, Magdalena
Introduction and aim. Paroxysmal non-epileptic events (PNEEs) are neurological conditions that include behavioral changes or disturbances of consciousness. The aim of the article is to compare individual paroxysmal non-epileptic events disorders, to indicate differences in their clinical picture and to discuss their differential diagnosis. Material and methods. A review of the most common non-epileptic paroxysmal events is presented based on the available literature of PubMed and Google Scholar databases from 2000 to 2023. Analysis of the literature. Depending on the age of the child, the nature and type of seizures are variable. Unfortunately, epilepsy is currently overdiagnosed, which results in the inclusion of antiepileptic drugs without the need to use them. This may be related to the immaturity of the central nervous system, malfunctioning of other organs or have a psychogenic background. In most cases, they do not require pharmacological treatment. Conclusion. Paroxysmal non-epileptic events, due to the diverse and uncharacteristic clinical picture, pose a major diagnostic challenge. Because of the current overdiagnosis of epilepsy they should always bear in mind differential diagnosis. This is important because of the differences in the treatment of these disorders.
Patterns and characteristics of traumatic dental injuries in children – a retrospective study in a dental hospital in Kolkata, India
(Publishing Office of the University of Rzeszow, 2024-03) Goswami, Suchetana
Introduction and aim. Traumatic dental injuries (TDIs) in children can have aesthetic, functional, and psychological conse quences. This retrospective study aimed to investigate the epidemiology and patterns of TDIs in a hospital-based population. Material and methods. Patient records from the Department of pediatric and Preventive Dentistry in a dental college and hospital in Kolkata, India, were reviewed. A total of 381 patients, aged 1 to 12 years, who presented one or more traumatized an terior teeth between September 2018 and August 2022, were included. Data on age, sex, mechanism of injury, type of trauma, dentition type, and number of affected teeth were collected. The World Health Organization classification system was used to classify the type of dental trauma. Results. Among the study population, there were 235 males (61.7%) and 146 females (38.3%), with a mean age of 7.67±3.87 years. Falls were the most common cause of trauma (52.2%). The maxillary central incisors were the most frequently affected teeth in both primary and permanent dentitions. Conclusion. Falls were the most common cause of trauma and the maxillary central incisors were the most commonly affected teeth in children.
PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
(Publishing Office of the University of Rzeszow, 2024-03) Ruffini, Livia; Zilioli, Alessandro; Cervati, Veronica; Lauretan, Fulvio; Misirocchi, Francesco; Maggio, Marcello; Migliari, Silvia; Graziani, Tiziano; Cidda, Carla; Baldari, Giorgio; Spallazzi, Marco; Scarlattei, Maura
Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may postpone or confound the final diagnosis. Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) radioligands provide target-specific information and may anticipate the diagnosis by “in vivo” detection of the neuro pathological substrate, as Aβ deposition, nigrostriatal dopaminergic depletion or tau inclusions. This concise review will dis cuss the potential of PET and SPECT imaging as a solid guide to better characterize atypical phenotypes of neurodegeneration in the clinical routine, with the potential to drive personalized interventions, improve cohort uniformity for clinical trials, and serve as biomarkers for targeted molecular therapies. Material and methods. Literature search was performed focusing on the role of PET and SPECT imaging in assessing atypical phenotypes of neurodegeneration, using the electronic source of database PubMed/MEDLINE and the web-based search engines Google, Google Scholar. Analysis of the literature. New disease-modifying drugs may increase their effect with early initiation, which is especially im portant in working persons and younger subjects presenting atypical symptoms. In older individuals, the coexistence of neu rodegeneration, age-related changes, cerebrovascular lesions, or depression makes challenging a definitive diagnosis. Quantitative tools able to measure tracer distribution increase the accuracy of molecular neuroimaging creating topographic maps that compare subject’s data with healthy controls databases. Conclusion. Atypical phenotypes may be associated with quantitative key-pattern allowing a more precise and early diagnosis of the neurodegenerative disorder. Finally, quantitative assessment of the pathological substrates allows us to track the disease process and measure treatment response.
Prolonged screen-time as the cause of ocular disorders: what can we do with the problem? – a review
(Publishing Office of the University of Rzeszow, 2024-03) Dyrek, Martyna; Sikorska, Ewa; Partyka, Aleksandra; Sikorski, Piotr; Dusza, Edyta; Kopacz, Dorota
Introduction and aim. Recently, an increased use of video display terminals has been observed in workplace environments, as a result of the evolution of communication technologies and new information-sharing strategies. It has led to an increased prevalence of computer-related ocular disorders, such as computer vision syndrome, dry eye disease, refractive errors and con vergence insufficiency. In this review we describe problems associated with these disorders and propose preventive methods. Material and methods. With the use of specific keywords, the databases of the PubMed, Science Direct, and Google Scholar were searched for relevant original papers. Analysis of the literature. The listed disorders might have similar symptoms, such as eye burning, itching, blurred vision, and tearing, and their severity correlates with the time of exposure to video display units. However, there are preventive measures, which can help in decreasing the negative effects of computers on our vision, such as adequate viewing distance, proper work space lighting, eyeglasses with anti-glare coating, taking 5-minutes breaks after every 30 minutes, or following the 20-20-20 rule. Conclusion. Prolonged usage of the video display terminals is connected to many ocular disorders, and in today’s world, it is very important to remember actions that can be undertaken to minimize the risk.
Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats
(Publishing Office of the University of Rzeszow, 2024-03) Ahmed, Abdul Baquee; Chetia, Purbajit
Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free rad icals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) acceler ated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-in duced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic pa rameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.
Simplified vs modified (reduced) ultrasound 6 joint score in assessing disease activity in rheumatoid arthritis patients
(Publishing Office of the University of Rzeszow, 2024-03) Gabal, Mervat Mamdouh Abo; Eldin, Amina Badr; Elserwy, Maha Ahmed; Mohammed, Mostafa Adel
Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity. Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores. Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients. Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice.

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