European Journal of Clinical and Experimental Medicine T.22, z. 1 (2024)

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Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats
(Publishing Office of the University of Rzeszow, 2024-03) Ahmed, Abdul Baquee; Chetia, Purbajit
Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free rad icals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) acceler ated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-in duced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic pa rameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.
Traditional teaching method versus simulation-based teaching method in the prevention of medication errors among nursing students
(Publishing Office of the University of Rzeszow, 2024-03) Ramamurthy, Rohini; Chitra, Felicia; Kavitha
Introduction and aim. The effective and safe administration of medication is the responsibility of every health care provider involved in patient care. One of the biggest problems with nursing education is the gap between theory and practice, which pave ways for medication errors to occur at any level of the medication administration process. This can be rectified by using an efficient teaching strategy that harmoniously blends nursing theory and practical skills. the aim of the study was to evaluate the effectiveness of the traditional teaching method versus simulation-based teaching method on level of knowledge, attitude, and practice on prevention of medication errors among nursing students in selected colleges, Puducherry. Material and methods. The research approach and design used for the study were quantitative approach and quasi-experi mental pre and post-test control group design respectively. The study settings were selected 4 nursing colleges in Puducherry. The sample size was 100 (50 in experimental group I and 50 in experimental group II) which was selected by using simple ran dom and stratified sampling technique. pre-test was done to assess the level of knowledge, attitude and practice on preven tion of medication error for both experimental groups utilizing the self-administered knowledge, attitude questionnaire and checklist. The experimental group I received traditional teaching method and experimental group II received simulation-based teaching method. Post-test was done after one week using the same tool. Results. The study results revealed that out of 100 nursing students, majority 35 (70%) and 38 (76%) of the nursing students were in the age group of 20–21 years, 40 (80%) and 39 (78%) of them were female, 50 (100%) and 41 (82%) of them were staying as day scholars, 40 (80%) and 41 (82%) had one attempt to clear the pharmacology subject in the experimental group I and II respectively. The level of knowledge, attitude, practice showed a statistically significance difference at p<0.05 between the pre and post-test within the experimental group I and II respectively. The effective mean scores of knowledge, attitude and practice showed a statistically significance difference at p<0.05 between the experimental group I and II respectively, revealed that the simulation-based teaching method was more effective over the traditional teaching method. There was a significant positive correlation at p<0.05 exist between the level of knowledge and attitude, knowledge and practice in the experimental group I. The association between the post-test level of attitude and the gender variable showed a statistically significant at p<0.05 in the experimental group II. Conclusion. The study concluded that the simulation-based teaching method was effective which can be utilized as a means to educate the nursing students during their academic performance.
Assessment of preoperative anxiety and negative automatic thoughts in patients waiting for corneal transplantation
(Publishing Office of the University of Rzeszow, 2024-03) Tanrıverdi, Seher; Şen, Mehmet Ali; Genç, Hasan
Introduction and aim. In patients waiting for organ transplantation, increased waiting time can increase anxiety by creating negative automatic thoughts. The aim of this study is to examine the relationship between corneal transplant recipients’ negative automatic thoughts and anxiety before organ transplantation. Material and methods. The population of this correlational descriptive study consisted of 108 patients waiting for cornea transplantation in the Eye Bank unit of a hospital in the south east region of Türkiye. The data were obtained from the patients presented to the ophthalmology clinic for transplantation between September and December 2022. A patient information form, the Negative Automatic Thoughts Scale, and the Trait Anxiety Scale were used to collect the data. Percentage distribution, arithmetic mean, logistic regression and correlation analysis were used in the data analysis. Results. It was determined that the mean score of the negative automatic thoughts of the transplant patients participating in the study was 100.69±47.83, and the trait anxiety mean score was 53.06±6.07. There was a positive relationship between neg ative automatic thoughts and trait anxiety at a moderate level, which was statistically significant (p<0.05, r=0.53). Conclusion. It was determined in the study that the patients’ negative automatic thoughts and trait anxiety were high, and their anxiety increased as the negative automatic thoughts increased.
Simplified vs modified (reduced) ultrasound 6 joint score in assessing disease activity in rheumatoid arthritis patients
(Publishing Office of the University of Rzeszow, 2024-03) Gabal, Mervat Mamdouh Abo; Eldin, Amina Badr; Elserwy, Maha Ahmed; Mohammed, Mostafa Adel
Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity. Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores. Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients. Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice.
Exploring barriers to vasectomy adoption among married men in Dadra and Nagar Haveli
(Publishing Office of the University of Rzeszow, 2024-03) Patel, Ronak Dhirubhai; Dabhelker, Monika M.; Patel, Priya Mahendrabhai; Solanki, Preeti
Introduction and aim. Vasectomy was introduced in India in 1992 and is the most effective, simple, and safe permanent method of contraception yet its use is very limited among the population. The study’s objectives were to assess the knowledge, attitude, and perception towards vasectomy and the barriers to adoption among married men in Dadra and Nagar Haveli. Material and methods. A cross-sectional hospital-based study was conducted on married male attendants of patients and data were collected on sociodemographic details, knowledge regarding vasectomy, their attitude and perceptions towards vasec tomy, and their intention of using vasectomy in the future. Results. Out of 300 participants, 258 (86%) participants have heard of vasectomy as a contraceptive method, and only one participant has undergone vasectomy. The majority (285; 95%) of the participants agreed that family planning is also a responsi bility of males while nearly two-third (185; 61.7%) of them were not willing to undergo vasectomy in the future. Procedure-re lated factors, post-procedure-related factors, social factors, availability of alternate contraceptive methods, and preference for tubectomy were the barriers to the adoption of vasectomy. Conclusion. There is a need to provide correct information and counseling about vasectomy and non-scalpel vasectomy to eligible couples to increase the acceptance of vasectomy as a safe, effective, and cheaper method of contraception.
Behaviors of pregnant women regarding travel – the case of Türkiye
(Publishing Office of the University of Rzeszow, 2024-03) Erciyas, Şeyma Kilci; Cirban-Ekrem, Ebru; Demir, Rukiye; Aköz, Gizem
Introduction and aim. With the development of transportation facilities and options, people can now travel easily. With women having a greater presence in the workforce, pregnant women can work until the eighth week before childbirth. This study was conducted to examine the behaviors of pregnant women regarding travel. Material and methods. The data for this cross-sectional and descriptive study were collected from 519 pregnant women who voluntarily participated in the research and met the research criteria. The data were analyzed using the SPSS 24 software package. Results. The average age of the participating pregnant women was 27.49±0.17, with 63.8% residing in urban areas, 74.8% be ing primiparous, and 47.6% being in the third trimester of pregnancy. A decrease in travel and car usage during pregnancy. The use of bus, train/tram/metro, taxi, bicycle/scooter, and motorcycle decreased during pregnancy, while use of car, plane, and ship/ferry increased. 81.9% of women always wore a seat belt during pregnancy. There was a statistically significant difference between the educational level of women and their car usage (p<0.005). It was found that women wore seat belts more frequently in the third trimester. As the number of pregnancies increased, the frequency of seat belt usage decreased. Conclusion. A decrease in the frequency of travel was observed among women during pregnancy. The levels of seat belt usage and correct seat belt fastening were unsatisfactory.
Determinants of distress levels in high-risk pregnant women – cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-03) Kara, Pınar; Nazik, Evşen; Çerçer, Zehra
Introduction and aim. Global and national care recommendations indicate that women with high-risk pregnancies should receive personalized and qualified care during this period. This study was conducted to determine the distress levels in high-risk pregnant women and affecting factors. Material and methods. The cross-sectional this study was conducted with total of 416 high-risk pregnant women who met the inclusion criteria in the obstetrics clinic of a training and research hospital. The study data were collected with data collection form and “Tilburg Pregnancy Distress Scale (TPDS).” Results. The mean TPDS total score of high-risk pregnant women was 18.25±6.85. It was found that planning pregnancy, gravida, and diagnosis of gestational hypertension, systemic diseases, and gestational diabetes in the present pregnancy was asso ciated with pregnancy-specific distress (p<0.05; β=0.291, β=0.158, β=0.272, β=0.137, β=0.116, respectively). Conclusion. It is advised that health professionals assess the distress levels of high-risk pregnant women and give personalized care during prenatal period.
Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State
(Publishing Office of the University of Rzeszow, 2024-03) Al-Tayeb, Al-Noor Opied; Abubakr, Mohammed Hayati; Elrheima, Hafsa Ahmed; Habbani, Ahmed Khalid; Elrasul, Rami Y. Hassab
Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group. Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001. Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
Effect of clinic-based and telemonitored home-based intervention on pain intensity, functioning and quality of life in patients with knee osteoarthritis
(Publishing Office of the University of Rzeszow, 2024-03) Ojoawo, Adesola Ojo; Odesanya, Oluwaseun; Kunuji, Kayode; Mbada, Chidozie Emmanuel; Adedeji, Oluwafemi Olusesan
Introduction and aim. The study assessed and compared the effects of clinic-based and telemonitored home-based interventions on pain intensity, functioning and quality of life in patients with knee osteoarthritis (KOA). Material and methods. Forty-two patients were recruited purposely and randomly allocated into clinic-based (CBG) and telemonitored home-based group (THG) equally. The CBG and THG received isometric exercises to strengthen the quadriceps and hamstring muscles using theraband. THG received the exercise at home they were monitored on phone thrice in a week, while the CBG did the exercise in the hospital. The subjects performed four sets of eight repetitions three days in a week for eight weeks. Pain intensity, functioning and health related quality of life (HRQoL) were assessed at pretreatment, 6th and 8th week of intervention. Data was analyzed with descriptive and inferential statistics. Alpha level was set at 0.05. Results. There was a significant reduction (p<0.001) among pre-treatment, 6th and 8th week intervention in pain intensity, functional pain intensity and quality of life of CBG and THG. CBG showed significant reduction (p<0.001) in pain intensity, function and increase in HRQoL than THG at 8th week. Conclusion. Clinic-based and telemonitored home-based interventions were both effective in the management of KOA but clinic-based intervention was better than telemonitored home-based intervention.
Expression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parameters
(Publishing Office of the University of Rzeszow, 2024-03) Panigrahi, Ranjita; Jha, Narendra Kumar; Hota, Subhransu Kumar
Introduction and aim. Angiogenesis, which is accomplished by capillary sprouting, is the process by which new vessels are created from pre-existing ones. In tumor, once their initial blood supply is depleted, a tumour is unable to grow without additional blood flow. Additionally, a tumor’s microvasculature, or microvessel density (MVD), increases along with its capacity to produce angiogenesis. We aimed to observe the relationship between the expression of vascular endothelial growth factor (VEGF) and MVD (using CD34) in oral squamous cell carcinoma (OSCC). Material and methods. The expression of VEGF and CD34 antibodies was analysed using immunohistochemistry method on 50 cases of histopathologically proved OSCC. The expression was correlated with clinicopathological parameters. Results. A significant correlation was observed between VEGF expression and gender, LVSI. No correlation between any other factors and the difference in VEGF expression was statistically significant. Similarly, the MVD expression was not found to be statistically significant in any of the pathological parameters. Conclusion. VEGF positivity as well as MVD were found to be independent of the tumor pathology. Tumor MVD was found to be independent of the expression of VEGF. Further studies in a larger study group may establish a significant association so that antiangiogenic targeted therapy may be initiated.
Surgical management of upper cervical esophagus stricture caused by ingestion of corrosive substances – a single-center experience
(Publishing Office of the University of Rzeszow, 2024-03) Mishra, Haris Chandra; Mohapatra, Jyotiranjan; Dash, Sashibhusan; Dash, Sanghamitra
Introduction and aim. Corrosive strictures of the upper cervical esophagus and hypopharynx are hard to treat in the operating room because there is a high chance of aspiration during swallowing after a high-up or proximal esophageal anastomosis. In this cases, we aimed to evaluate the role of intraoperative dilatation of the proximal hypopharyngeal and cervical esophageal stumps during surgery. Material and methods. Patients who underwent surgery and had upper cervical esophageal and hypopharyngeal strictures from corrosive substance ingestion were included. Results. Out of total 27 patients, 10 had a cricopharyngeal or proximal cervical esophageal stricture with a long segment tho racic esophageal stricture that was treated with intra-operative dilatation (IOD) of the proximal hypopharyngeal stump. IOD was done in two cases with Hegar’s dilator and in three cases with wire-guided Savary Gillard dilators. In 74% (20/27) of the cases, the colon was frequently used as an esophageal substitute, while the stomach was only used in 10 cases. On follow-up, none of them developed repeated aspirations or required a tracheotomy. Conclusion. IOD of the proximal hypopharyngeal and cervical esophageal stumps during surgery for corrosive upper cervi cal esophageal or cricopharyngeal strictures helps to save the proximal stump and avoid frequent hospital stays and multiple surgeries.
Identification of Brucella melitensis from camel’s blood by vitek2 and real time polymerase chain reaction
(Publishing Office of the University of Rzeszow, 2024-03) Manivannan, Kavitha; Ramasamy, Malathi; Sundaresan, Uma; Moustafa, Samar M.; Sherloumay; Mariyam, Safna
Introduction and aim. Brucellosis is a zoonotic disease. Experimental clinical and laboratory diagnosis is still facing problems in identifying the organism. The present study will diagnose a Brucella infection in camel blood in Qatar using serological assays. Isolation and identification were performed on a camel blood sample. Brucella in bacterial isolates was determined by real-time polymerase chain reaction (RT-PCR) as a gold standard test. Material and methods. A total of 220 samples, 200 random serum samples, and 20 EDTA blood samples were selected among the above-mentioned random samples, and 20 serum samples from camel handlers were collected from Al Shahaniya prov ince, Qatar. The Rose Bengal test (RBT), buffered antigen plate agglutination test (BAPAT), and enzyme linked immunosorbent assay (cELISA) for the monoclonal antibody in serum samples were performed using commercially available kits. For the molecular detection of Brucella, conventional PCR and real-time PCR (GPS kit) were used for the genus-specific insertion sequence IS711. Brucella melitensis (MICROBOSS Hightech GmbH kit) was used to identify subspecies. Results. The results identified by vitek2 compact (30%) showed B. melitensis in 6 samples out of 20 isolates. Both conventional (66.67%) and RT-PCR (83.33%) analyses supported this, demonstrating the presence of Brucella. These tests also showed that Brucella species were present in Rose Bengal 182/200 (91%), BAPAT 182/200 (91%), and cELISA (90%) 180/200 in camel serum. Conclusion. To conclude, the prevalence of brucellosis in dromedary camels is higher in this region, and as a matter of urgency, measures should be taken to control the disease.
Unveiling challenges in cadaveric dissection for medical education – a study of student perspectives
(Publishing Office of the University of Rzeszow, 2024-03) K., Sudha; James, Jerin; Natarajan, Pratheepa Sivasankari; Subramanian, Sundara Pandian
Introduction and aim. Cadaveric dissection is the mainstay of learning anatomy by medical students. Even though newer teaching learning methodologies have been implemented to facilitate learning anatomy, cadaveric dissection remains the most preferred method by students. The objective of this study was to analyze the student perspective of different aspects of learning anatomy with their positive and negative experiences and to get a better understanding of their opinions and their experience. Material and methods. In this cross-sectional study, a pretested and validated questionnaire was used to collect information from the students after approval from the Institutional Ethics Committee. Informed consent was obtained from every student prior to their participation in the study. Results. Three hundred seventy-seven students took part in this study and the response rate obtained was 63.5%. The majority of the students stated that cadaveric dissection has helped them in learning basic anatomy and had deepened their under standing of complexity of human body and has helped in better performance in clinical applications. The smell of formalde hyde and eye irritation was cited as the major reasons for finding dissection sessions challenging. Most of the students agreed that counselling before dissection sessions will help to alleviate the emotional reactions to cadavers. Conclusion. The students unanimously agreed that cadaveric dissection sessions are the best way to learn basic anatomy com plemented with newer teaching tools like prosection and computer-based approaches. However, the problems encountered by the students like smell and irritation of formaldehyde need to be addressed with usage of alternative techniques.
Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study
(Publishing Office of the University of Rzeszow, 2024-03) Stepanova, Natalia; Rysyev, Andriy; Snisar, Lyudmyla
Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the rela tionship between preexisting dialysis dose, measured by single pool Kt/V (spKt/V), and long-term outcomes of COVID-19 in patients undergoing HD. Material and methods. Demographic, clinical, and laboratory parameters following COVID-19 recovery, and long-term out comes, including the presence of COVID-19 sequelae, hospitalization, and all-cause mortality during a year after COVID-19 were retrospectively analyzed. Results. Out of the 195 patients included, there were 108 males (55.4%) and 87 females (44.6%), with a median age of 56 (44-63) years and a dialysis duration of 49 (31.3–85.2) months. Patients with spKt/V<1.4 had a significantly increased risk of long-term COVID-19 sequelae (HR 9.1, 95% CI: 3.4; 24.6), hospitalization (HR 7.6, 95% CI: 3.9; 14.6), and all-cause mortality (HR 8.5, 95% CI: 2.9; 25.8) within one year after COVID-19 recovery compared with those with spKt/V≥1.4. spKt/V cutoff point of ≤1.3 emerged as a significant risk factor for one-year hospitalization and mortality within our cohort. Conclusion. Suboptimal dialysis dose, as indicated by spKt/V < 1.4, is associated with adverse long-term COVID-19 outcomes in patients undergoing HD. Optimizing dialysis adequacy may mitigate these risks. Further research is needed to validate these f indings and explore interventions to improve outcomes in this vulnerable population.
The content of lactoferrin and interleukin-8 in breast milk of patients with lactational mastitis
(Publishing Office of the University of Rzeszow, 2024-03) Demianchuk, Nataliia; Akimova, Viorika; Soyka, Larysa; Shchurko, Mariia; Lapovets, Lyubov; Lutsiv, Nataliia; Tkachuk, Serhii; Buchko, Olha; Zubchenko, Svitlana; Hayduchok, Ihor
Introduction and aim. Information concerning lactoferrin and interleukin-8 (IL-8) local levels in breast milk are not numerous and requires further research. The aim of this study was to determine the content of lactoferrin and interleukin-8 in the breast milk of patients with lactational mastitis, and to identify new potential markers for assessing the activity of the inflammatory process in the mammary gland. Material and methods. This study analyzed the breast milk of 30 women with lactostasis (group I), 37 women with lactational mastitis (group II) and 30 healthy lactating women (age 26±5 years old). The milk content of lactoferrin and interleukin-8 (IL-8) was determined by enzyme-linked immunosorbent assay. Results. The average value of lactoferrin in breast milk of healthy women was 4.78±0.47 mg/mL, exceeding levels in group I 1.8 times (p<0.05). The level of lactoferrin in group II exceeds the control values 3.1 times (p<0.05). The content of IL-8 in breast milk of women in group I was 7.3 times higher than the control (3.63±0.12 pg/mL, p<0.05). In lactational mastitis, the concentration of IL-8 in breast milk exceeded the group I 13.9 times (p<0.05) and was 1.9 times higher than group I (p<0.05). Conclusion. The analysis has revealed an increase of lactoferrin and IL-8 in breast milk of the test groups, which indicates the activation of non-specific protection.
Assessment of hepatorenal biochemical indices in male Sprague Dawley rats preceding concurrent oral administration of Ghana alcoholic bitters and natural cocoa powder
(Publishing Office of the University of Rzeszow, 2024) Maalman, Raymond Saa-Eru; Bimpong, Samuel; Abaidoo, Chrissie Stansie; Cuba, Magalys Lopez; Kumi, Michael Barima; Sarkodie, Francis Kofi
Introduction and aim. There has been a surge in the consumption of Ghanaian alcoholic bitters. Ghanaian alcoholic bitters are formulated from a maceration of not less than three plant parts making the organic composition very complex. There appear to be no studies on the effect of Ghanaian alcoholic bitters on the hepatorenal biochemistry indices. The study aimed to assess the effects of alcoholic bitters and cocoa powder on the liver and kidney serum biochemistry. Material and methods. Twenty-four healthy male Sprague Dawley rats, age 11–12 weeks, weighing 150–250 g were used. The rats were randomly assigned to four groups (n=6). At the end of the experimentation, a blood sample was taken by cardiac puncture and centrifuged to obtain the serum for biochemical assays and analysis. Results. The liver enzymes showed no significant difference between the treatment and control groups. There were higher mean values for total bilirubin and direct bilirubin for alcoholic bitters and natural cocoa powder groups respectively than the control group and the co-administration of alcoholic bitters and natural cocoa powder group. Conclusion. The study concludes that alcoholic bitters consumption might cause injury to the liver and kidney resulting in anomaly of the hepatorenal indices from rat blood serum biochemistry.
Stigma and its relationship with life satisfaction in patients with type 2 diabetes mellitus
(Publishing Office of the University of Rzeszow, 2024-03) Turen, Sevda; Yurtsever, Melike
Introduction and aim. This study aims to determine the level of stigma in patients with type 2 diabetes mellitus (T2DM) and evaluate its relationship with their life satisfaction. Material and methods. This is a descriptive and cross-sectional study conducted in a single tertiary care center. Two hundred and ten patients ≥18 years old diagnosed with T2DM were included in this study. The relationship between the “Type 2 diabetes stigma assessment scale” and the “Satisfaction with life scale” was assessed using Pearson correlation analysis. Results. The average age of the participants was 54.85±15.81 years. The majority of patients reported adherence to diabetes treatment and having comorbidities. Stigma levels were higher in patients ≤65 years, those with less than a high school educa tion, and those receiving insulin or oral anti-diabetic treatment, but lower with a T2DM diagnosis duration of ≤ 5 years (p<0.05). Life satisfaction was influenced by age, education status, economic status, adherence to treatment, dietary compliance, and the presence of comorbidities. A moderately negative relationship between stigma level and life satisfaction was identified. Conclusion. The study’s results indicate that an increase in stigma level is associated with a decrease in life satisfaction in patients with type 2 diabetes mellitus.
Patterns and characteristics of traumatic dental injuries in children – a retrospective study in a dental hospital in Kolkata, India
(Publishing Office of the University of Rzeszow, 2024-03) Goswami, Suchetana
Introduction and aim. Traumatic dental injuries (TDIs) in children can have aesthetic, functional, and psychological conse quences. This retrospective study aimed to investigate the epidemiology and patterns of TDIs in a hospital-based population. Material and methods. Patient records from the Department of pediatric and Preventive Dentistry in a dental college and hospital in Kolkata, India, were reviewed. A total of 381 patients, aged 1 to 12 years, who presented one or more traumatized an terior teeth between September 2018 and August 2022, were included. Data on age, sex, mechanism of injury, type of trauma, dentition type, and number of affected teeth were collected. The World Health Organization classification system was used to classify the type of dental trauma. Results. Among the study population, there were 235 males (61.7%) and 146 females (38.3%), with a mean age of 7.67±3.87 years. Falls were the most common cause of trauma (52.2%). The maxillary central incisors were the most frequently affected teeth in both primary and permanent dentitions. Conclusion. Falls were the most common cause of trauma and the maxillary central incisors were the most commonly affected teeth in children.
The influence of therapeutic education on diabetes-related distress and therapeutic adherence among patients with type 2 diabetes in Tetouan, Morocco
(Publishing Office of the University of Rzeszow, 2024-03) Belhaj, Hajar; Barouaca, Hassan; Oudghiri, Dia Eddine; Abderrahmane, Lamiri; Mostakim, Mohammed; Timihiri, Abderrahim; Ahyayauch, Hasna; Younes, Saoud
Introduction and aim. Diabetes-related distress is a prevalent issue that affects many patients, leading to challenges in ad hering to treatment plans and lifestyle modifications. By implementing therapeutic education programs, healthcare providers seek to enhance patients’ understanding of their condition, coping mechanisms, and treatment adherence. This study aims to explore the impact of therapeutic education on diabetes-related distress and therapeutic adherence among individuals diag nosed with type 2 diabetes. Material and methods. This quasi-experimental study involved 40 patients with type 2 diabetes receiving therapeutic educa tion during 6 Months from March 24 to September 30, 2022. Diabetes-related distress and adherence were assessed before and after the intervention using the Diabetes Distress Scale (DDS-17) and glycated hemoglobin (HbA1c) levels. Results. Wilcoxon signed rank tests revealed statistically significant improvements for all measures after the intervention. Patients showed improved DDS-17 scores (p<0.001) across all dimensions, and lower HbA1c levels (p<0.001). Pre- and post-inter vention mean difference across all measures show that the greatest improvements were seen in emotional distress (1.37) and treatment-related distress (1.2). Conclusion. Therapeutic education had a positive impact on therapeutic adherence and diabetes-related distress. It should be an integral part of type 2 diabetes care protocols in Morocco.
Caring and therapeutic services – a patient’s opinion on experience and satisfaction with night nursing care
(Publishing Office of the University of Rzeszow, 2024-03) Fąfara, Anna; Krakowiak-Burdzy, Anna
Introduction and aim. Night nursing care ensures well-being, peace, and security allowing a patient to enter into the deep sleep phase. This study aims to analyze the relationship between an assessment of caring and therapeutic services and the opinion of in-patients on their experience and satisfaction with night nursing care. Material and methods. A questionnaire developed by the authors and the Newcastle Satisfaction with Nursing Scale were used in this study. This study was conducted in the eastern region of Poland in the Podkarpackie province. The study included 585 patients. Results. Tasks analyzed resulting from care and therapeutic functions, in the patient’s opinion, had a significant impact on the overall assessment of nursing care. Meeting the expectations regarding night rest (experience of nursing care) and satisfaction showed the strongest correlation. Tasks resulting from therapeutic functions showed an average correlation with the exception of planned medical care. Conclusion. The level of implemented health services by nurses at night significantly influences the overall assessment of the quality management system in health care.

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