Repozytorium Uniwersytetu Rzeszowskiego

Witamy w Repozytorium UR: cyfrowym archiwum dorobku naukowego i dydaktycznego Uniwersytetu Rzeszowskiego.

Serwis zapewnia otwarty dostęp do materiałów naukowych i akademickich. Proces archiwizacji publikacji jest realizowany samodzielnie przez pracowników i doktorantów UR.

Jak korzystać z serwisu?

  • Pracownicy UR: zaloguj się za pomocą danych uwierzytelniających z systemu Wirtualnej Uczelni/EOD, które automatycznie aktywują konto.
  • Doktoranci UR: przed pierwszym dodaniem materiałów wymagana jest rejestracja, kliknij ZAREJESTRUJ SIĘ.
  • Czytelnicy: przeglądaj zbiory poniżej lub skorzystaj z wyszukiwarki i indeksów.

Odkryj

Zbiory w Repozytorium UR

Wybierz Zbiór, aby przeglądać jego Kolekcje

Najnowsze publikacje

  • Miniatura
    Item type: Pozycja ,
    Antiphospholipid syndrome in an adolescent with refractory immune thrombocytopenia and massive central venous thrombosis
    (Rzeszów University Press, 2026-06) Mikołajczyk, Matylda Marcelina; Bal, Wioletta; Mastej-Witek, Gabriela; Chaber, Radosław
    Introduction and aim. Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) may coexist, creating a clinical paradox of simultaneous bleeding risk and thrombophilia. In children and adolescents, APS may remain unrecognised for years when thrombocytopenia dominates the early course. The thrombotic risk associated with thrombopoietin receptor agonists (TPO-RAs) in this setting remains uncertain. Description of the case. A 17-year-old boy with refractory ITP during romiplostim therapy developed massive upper-extremity and central venous thrombosis with near-complete superior vena cava obstruction. Persistent lupus anticoagulant, anticardi olipin, and anti-β2-glycoprotein I antibody positivity established APS. He was treated with heparin, alteplase, and long-term warfarin plus low-dose aspirin, while romiplostim was continued to support safe anticoagulation. No recurrent thrombosis or major bleeding was observed during 20 months of follow-up. Conclusion. Thrombocytopenia does not protect against thrombosis in APS. In adolescents with chronic or refractory ITP, especial ly when vascular symptoms, unexplained prolonged aPTT, or other autoimmune red flags are present, targeted antiphospholipid antibody testing should be considered. Management of combined ITP and APS requires individualized balancing of anticoagula tion and platelet support, with vitamin K antagonists remaining the preferred long-term anticoagulant strategy in high-risk APS.
  • Miniatura
    Item type: Pozycja ,
    Should oophoropexy be a standard procedure after ovarian torsion in premenarchal patients? A case-based review of fixation indications and techniques
    (Rzeszów University Press, 2026-06) Nogaj, Zuzanna; Januszkiewicz-Lewandowska, Danuta; Kaźmierowska, Anna; Jurczok, Marta; Mańkowski, Przemysław; Sosnowska-Sienkiewicz, Patrycja
    Introduction and aim. Ovarian torsion is a rare but significant cause of acute abdomen in children. Diagnosis is challenging due to nonspecific symptoms. While Doppler ultrasound is essential, it is not definitive. Laparoscopy with detorsion remains the diagnostic and therapeutic standard. For recurrent and high-risk cases, oophoropexy is considered, but there is no consensus on its indications or optimal technique. We analyze the diagnostic process, reasons for recurrence, and outcomes of different oophoropexy techniques. Description of the case. A premenarchal girl experienced three episodes of ipsilateral ovarian torsion. After the second recurrence, she underwent laparoscopic oophoropexy via fixation posterior to the uterus to the ovarian fossa with absorbable sutures, which failed. Following a third torsion, a laparotomy with a subsequent oophoropexy to the round ligament using non-absorbable sutures achieved a long-term recurrence-free period. Conclusion. Retorsion remains a significant risk. This case provides a unique intrapatient comparison, demonstrating that the technical approach influences the outcomes. Fixation to the abdominal wall with non-absorbable sutures proved to be superior in this scenario, preventing further recurrence. The patient's age and torsion etiology are critical in selecting a fixation method. This report highlights the potential for oophoropexy failure and offers vital technical insights, underscoring the need for further studies to standardize practices for fertility preservation.
  • Miniatura
    Item type: Pozycja ,
    Relationship between anatomical variations in the aortic arch and risk of aneurysm formation ‒ a systematic review
    (Rzeszów University Press, 2026-06) Jain, Sanjeev Kumar; Sharma, Sonika
    Introduction and aim. Anatomical variation in the aortic arch has been proposed as an aneurysm risk factor based on changed hemodynamic forces and structural stress in arterial walls. Knowledge of these variations will be valuable in optimizing surgical planning and management of risks for patients to undergo cardiovascular and thoracic procedures. This systematic review summarized existing literature to assess the relation of different variations in the aortic arch with the risk of aneurysm formation by consolidating evidence of clinical relevance and predictive markers of risk. Material and methods. We conducted our searches in seven databases: PubMed, Embase, Scopus, Web of Science, Cochrane Library, CINAHL, and ProQuest, using Boolean operators and MeSH terms. The ROBINS-I tool was used to assess the risk of bias in studies, including confounding, participant selection, and outcome reporting. GRADE was used to evaluate global certainty of evidence, which also considered consistency, directness, and precision of evidence. Studies were eligible based on strict eligibility criteria and reported findings on specific aortic arch and their potential association with aneurysm formation. Results. The review included 12 studies that varied in terms of sample size and used a mostly retrospective design. According to the findings evaluated, certain forms of the aortic arch, for example, the bovine arch and aberrant right subclavian artery, posed an increased risk of developing proximal versus distal aneurysms. Advanced imaging studies, such as 4D flow MRI and enhanced CT, aided in the selection of at-risk patients, as they described the flow pressure dynamics with detailed assessments. While several authors reported consistent associations of anatomical variation with risk, other authors found no significant correlation and thus suggested variability in clinical relevance. The general review showed both converging and divergent findings of the review about the predictive value of certain types of arch for aneurysm risk. Conclusion. This systematic review highlights the incorporation of knowledge on aortic arch variation as part of the detailed risk assessment required in aneurysmal formation among patients. Although some forms, such as the bovine arch and the aberrant right subclavian artery, did indeed demonstrate the potential to be predictive of complications, study inconsistencies provide reason for continuing research on the topic. Advanced imaging may improve medical decision-making, as patient risk stratification would be feasible with greater information on anatomical variation.
  • Miniatura
    Item type: Pozycja ,
    The role of glutathione peroxidase enzymes in Alzheimer's disease
    (Rzeszów University Press, 2026-06) Kordatzakis, Alexandros; Kourkouliotis, Margaux; Hadjiyianni, Andriana; Arifagic, Emma; Paradeisi, Eleni; Kalali, Datis
    Introduction and aim. Alzheimer’s disease (AD) is a neurodegenerative disorder that affects mainly the elderly. Among the variety of factors contributing to the pathogenesis of AD, oxidative stress has emerged as a key factor in the initiation and progression of the disease. Glutathione peroxidases (GPxs) are enzymes that are known to play a critical role in maintaining cellular redox balance. To this end, the present narrative review aims to explore the role of GPx enzymes in AD and discuss their contribution to oxidative stress pathways and AD pathogenesis. Literature search. PubMed, Scopus, and Google Scholar were searched for relevant literature. No specific inclusion and exclusion criteria were used due to the narrative nature of the review. Analysis of the literature. Available records suggest a strong association between oxidative stress and the pathological features of AD, including amyloid-β aggregation, tau hyperphosphorylation, and neuroinflammation. The enzyme isoforms GPx1, GPx3, and GPx4 have been implicated in AD pathogenesis. Conclusions: GPx enzymes play an important protective role in AD. Despite promising preclinical evidence, more translational research is required to clarify the therapeutic and biomarker potential of GPxs in AD.
  • Miniatura
    Item type: Pozycja ,
    Breast imaging on chest computed tomography after various types of breast surgery
    (Rzeszów University Press, 2026-06) Kang, Taekyung; Kang, Mi-Jin
    Introduction and aim. The incidence of breast cancer is increasing globally, prompting the development of various surgical and reconstructive techniques for treatment. Chest computed tomography (CT) is frequently performed for multiple clinical indications, including screening, postoperative surveillance, and staging. Therefore, this article aims to review and illustrate the characteristic imaging characteristics of various postoperative breast changes that may be incidentally identified on chest CT. Material and methods. We reviewed the medical records of patients who underwent CT scans at our hospital in the past five years and had changes in the shape of their breasts to confirm diagnosis, surgery, or procedure name, etc. Analysis of the literature. We compared CT findings of patients with surgically confirmed procedures with the surgical tech niques to identify any deformities resulting from surgery. In addition, we investigated the indications and effects of each surgery. Conclusion. Awareness of these characteristic CT appearances can help radiologists avoid misinterpretation, recognize complications or recurrence, and provide clinically relevant information even when breast findings are incidental.