Repozytorium Uniwersytetu Rzeszowskiego

Witamy w Repozytorium UR: cyfrowym archiwum dorobku naukowego i dydaktycznego Uniwersytetu Rzeszowskiego.

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Najnowsze publikacje

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    Reliability and Validity of the ALFA Stabilometric Platform in Healthy Young Adults
    (2026-09-04) Wołoszyn, Natalia; Brożonowicz, Justyna; Ciąpała, Gabriela; Bylicki, Krzysztof; Leszczak, Justyna; Grzegorczyk, Joanna; Wiśniowska-Szurlej, Agnieszka
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    Evaluation of serum and follicular fluid progranulin in relevance to BMI, oocyte, and embryo quality in Iraqi women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection
    (Rzeszów University Press, 2026-06) Al-Zori, Inaam Khazal S.; Abood, Muayad Sraibet; Mossa, Hayder A. L.
    Introduction and aim. Polycystic ovarian syndrome (PCOS) is a common endocrine-metabolic disease often associated with obesity, persistent low-grade inflammation, and suboptimal results of assisted reproductive technology (ART). The aim was to evaluate the relevance of serum and follicular progranulin (PGRN) levels in relation to intracytoplasmic sperm injection outcomes among normal and overweight/obese body mass index (BMI) women with PCOS. Material and methods. This prospective comparative study included women diagnosed with PCOS undergoing intracytoplasmic sperm injection (ICSI) between the first of October 2024 and the first of April 2025. Baseline serum markers were measured on cycle days 2‒3. Participants were categorized as having a normal BMI, group 1 (n=30), or being overweight/obese, group 2 (n=37). Fasting serum and follicular fluid progranulin (PGRN) levels were assessed on oocyte retrieval day. Results. Women with normal BMI were younger and had significantly lower BMI and shorter infertility duration compared with overweight/obese women (p≤0.05). No statistically significant differences were observed between BMI groups in the number of retrieved oocytes, MII oocytes, fertilized oocytes, embryo grades, blastocysts, or biochemical pregnancy rate (p>0.05). Numerically, normal-BMI women showed slightly higher retrieved and MII oocyte counts, whereas overweight/obese women demonstrated higher numbers of fertilized oocytes, total embryos, grade I embryos, blastocysts, and biochemical pregnancy rates; however, these differences did not reach statistical significance. Serum and follicular fluid PGRN levels were comparable between groups (p>0.05), with only limited correlations observed between follicular fluid PGRN and total oocyte count. Conclusion. Serum and follicular fluid PGRN levels were comparable across BMI categories in women with PCOS undergoing ICSI. Although numerical variations in oocyte and embryo parameters were observed between BMI groups, most differences were not statistically significant. The findings suggest that follicular fluid PGRN may be associated with certain ovarian response parameters; however, its independent clinical relevance in predicting ART outcomes remains uncertain. Larger studies incorporating clinical pregnancy and live birth outcomes are required to clarify the potential role of follicular fluid PGRN in PCOS-related infertility.
  • Miniatura
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    Ultrasonographic features of pediatric umbilical hernias ‒ associations with age, sex, and hernial orifice width
    (Rzeszów University Press, 2026-06) Kawalec-Rutkowska, Agata Maria
    Introduction and aim. Given the limited data on standardized ultrasound evaluation of hernial defect morphology in pediatric umbilical hernias, this study aimed to evaluate the ultrasonographic features of primary umbilical hernias in pediatric patients, with a particular focus on the width of the hernial orifice, the contents of the hernial sac and their potential correlation with age and sex. Material and methods. A retrospective analysis of medical records of pediatric patients with primary umbilical hernia who presented to the pediatric surgery outpatient clinic and had ultrasonographic measurements performed using a standardized protocol between 01.01.2024 and 31.07.2025. Results. Analysis of ultrasound measurements of the width of the hernial orifice width demonstrated a significant association between the width of the hernial orifice and the contents of the hernial sac. Children with intestinal loops present in the hernial sac were significantly younger than those with preperitoneal fat (p=0.016), and the width of the hernial orifice was greater in cases containing intestinal loops (p=0.028). In particular, among children with a hernial orifice larger than 14 mm, intestinal loops were observed more frequently than among those with an orifice width of 14 mm or less (58.82% vs 15.38%; p=0.026). Furthermore, the analysis revealed that the umbilical orifice was wider in boys than in girls (mean±SD: 15.44±1.64mm vs. 13.08±2.43mm; p=0.043).There was a difference between the width of the hernial orifice in children under 1 year of age and older. Conclusion. Ultrasonographic evaluation of pediatric umbilical hernias provides clinically relevant information on the morphology of hernial defects. In particular, the width of the hernial orifice is associated with the presence of intestinal loops in the hernial sac, especially in younger children, with a threshold value of >14 mm identifying patients at higher likelihood of intestinal content. These findings suggest that ultrasonography may contribute to risk stratification and support clinical decision-making in the management and follow-up of pediatric umbilical hernias.
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    Association of vitamin D deficiency with inflammatory cytokines and disease severity in chronic heart failure
    (Rzeszów University Press, 2026-06) Almammadov, Fazil Choban
    Introduction and aim. Vitamin D deficiency has been associated with impaired cardiovascular dysfunction and adverse outcomes in chronic heart failure (CHF); yet the connection between inflammatory and cardiac biomarkers in different disease severities remains incompletely understood. Therefore, this study aimed to investigate the role of vitamin D and related biochemical parameters in the etiopathophysiology and severity of chronic heart failure. Material and methods. A total of 219 people diagnosed with chronic heart failure, aged 30 and 89 years, were enrolled and stratified according to the functional class (I–II, n=123; III–IV, n=96). An age and sex-matched control group of 51 apparently healthy individuals was included. Serum levels of vitamin D, natriuretic peptide (BNP), N-terminal pro–brain natriuretic peptide (NT-proBNP), interleukin-6 (IL-6), interleukin-18 (IL-18) and tumor necrosis factor-alpha (TNF-α), galectin-3 and fibroblast growth factor-23 (FGF-23) were quantified using validated immunoassays. Comparisons between groups were performed using nonparametric statistical tests. Associations between variables were evaluated using Spearman’s correlation analysis. The diagnostic utility of the selected biomarkers for different levels of severity of CHF was evaluated using receiver operating characteristic (ROC) curve analysis. Results. Vitamin D deficiency was associated with CHF severity. Across increasing NYHA functional classes, serum levels of IL-6, IL-18, TNF-α, BNP, NT-proBNP, galectin-3, and FGF-23 differed significantly (p<0.001). Vitamin D concentrations were positively associated with left ventricular ejection fraction and inversely related to BNP, NT-proBNP, IL-6, IL-18, TNF-α, galectin-3, and FGF-23. ROC analysis indicated that IL-6 (AUC 0.799, sensitivity 75%, specificity 78%) and galectin-3 (AUC 0.791, sensitivity 72%, specificity 80%) were the most discriminative biomarkers in patients with CHF with vitamin D deficiency, supporting their clinical utility for risk stratification and disease monitoring. Conclusion. This study provides novel evidence by integrating inflammatory cytokines, galectin-3, FGF-23, and natriuretic peptides in patients with vitamin D-deficient CHF, identifying IL-6 and galectin-3 as the most discriminative biomarkers of disease severity in this clinical setting.