European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023)


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  • Pozycja
    Speech development delay in autism spectrum disorder – the perspective of using the “Talk To Me” speech therapy application
    (Publishing Office of the University of Rzeszow, 2023-12) Warmbier, Wojciech A.; Perenc, Lidia; Piwoński, Paweł; Podgórska-Bednarz, Justyna
    Introduction and aim. The paper aims to present the prospects of using the „Talk To Me” application in the case of a child with this neurodevelopmental disorder. Description of the case. The subject of the study was a 53-month-old boy who did not communicate verbally, but behaved forcefully. A child underwent a speech therapy using the „Talk To Me” application for a period of 12 weeks. The scale of acquiring language skills in the field of communication competence was used to monitor the progress of therapy. In the analyzed period, a decrease in the score on the scale from 23 to 15 points was observed, which means a result indicating an improvement in the communication sphere. The use of a newly developed therapeutic tool was an important motivational factor and, in the opinion of the boy’s mother, significantly influenced the progress in therapy, which had not been observed before using a conventional approach. Conclusion. The „Talk To Me” application is a therapeutic tool with potential effectiveness in the case of speech delays in children with autism spectrum disorder, and it is also compatible with behavioral therapy, a widely used therapeutic method with proven effectiveness in autism spectrum disorder.
  • Pozycja
    Secondary Fahr’s syndrome mimicking meningoencephalitis
    (Publishing Office of the University of Rzeszow, 2023-12) Vamshikrishnapatel, Kotha; Kumar, Vijay; Biswas, Ratnadeep; Ojha, Vishnu S; Hegde, Aniketh V.
    Introduction and aim. Fahr’s disease is a rare neurological disorder characterized by bilateral basal ganglia calcifications. The aim of this report is to highlight a case of Fahr’s disease with atypical features such as neck rigidity and peripheral nerve involvement. Description of the case. Here, we present the case of a South Asian patient with secondary Fahr’s disease whose clinical presentation mimicked that of meningoencephalitis. The patient had neurological and neuropsychiatric symptoms along with abnormal body movements. She also had restricted neck mobility. Computed tomography of the head revealed bilateral dense calcifications in the basal ganglia suggestive of Fahr’s syndrome. Investigations revealed severe hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels, which led to the identification of hypoparathyroidism as the underlying cause. The presence of pre-existing epilepsy and neck rigidity made the diagnosis difficult. The relatively rapid development of symptoms along with the presence of peripheral nerve involvement made this case even more unique. Calcium levels were corrected, and there was a marked symptomatic improvement. Conclusion. Neck rigidity and restricted neck mobility may be present in cases of Fahr’s syndrome due to calcifications of the nuchal ligament or other spinal ligaments and thus must be differentiated from meningoencephalitis. Although the symptoms of Fahr’s syndrome are generally limited to the central nervous system, there may be involvement of the peripheral nerves as well.
  • Pozycja
    Demystifying the intricacies – a rare report of two cases of biradicular permanent mandibular lateral incisor and their endodontic management
    (Publishing Office of the University of Rzeszow, 2023-12) Makkar, Sameer; Gupta, Sandeep; Singh, Aiana; Rohilla, Smriti
    Introduction and aim. One of the imperative reasons for endodontic failure is an extra or missed root and root canals. Permanent mandibular lateral incisors generally present as monoradicular tooth with one or two canals, but aberrancies in the form of extra root are also rarely seen. There is insufficiency in the literary work regarding the presence of an extra root in permanent mandibular lateral incisor. We hereby report two illustrious cases of biradicular permanent mandibular lateral incisors and their endodontic management and brief review regarding the case reports published so far regarding the existence of an extra root in permanent mandibular lateral incisor in the literature. Also, we intend to apprise the scientific documentation with the aforementioned. Description of the cases. Case 1. A twenty-two-year-old male patient of Indian origin was referred to endodontic clinic for intentional root canal therapy. Pre-operative radiograph revealed 32 exhibited aberrancy in the form of an extra root, with normal periodontal structures and bone architecture. Case 2. A sixty-two-year-old male patient came to the Department of Conservative Dentistry and Endodontics with the chief complaint of pain in the lower anterior tooth region. Radiographic examination revealed root caries on the mesial side and two roots with two canals with bifurcation at the level of middle third of root. Conclusion. Clinicians should be well prepared in advance for management of any anatomical aberrancy in their clinical practice by having a scrupulous knowledge of root canal system.
  • Pozycja
    Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond
    (Publishing Office of the University of Rzeszow, 2023-12) Singh, Dhishank; Kaur, Ginpreet; Chintamaneni, Meena; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh
    Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases. Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar. Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation. Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.
  • Pozycja
    The gut microbiota in development and treatment of depression
    (Publishing Office of the University of Rzeszow, 2023-12) Wilczek, Natalia; Bogucka, Julia; Brzyska, Anna; Sielwanowska, Wiktoria; Syzdoł, Bartłomiej; Piecewicz-Szczęsna, Halina
    Introduction and aim. Nowadays, almost 4% of people in the world suffer from depressive disorders, and the forecasts of further increase in incidence are alarming. The disease is debilitating and can lead to suicide, and available treatments are still imperfect. The aim of the study was to review the literature and present the potential role of the gut microbiota in the development of depression and to consider the use of prebiotics and probiotics as one of the therapeutic options in this disease. Material and methods. Review of articles published on PubMed since 2015. Analysis of the literature. The available reports point to a relationship between disturbances in the composition of the intestinal flora and the development of depressive disorders. In addition, more and more studies indicate the benefits of the influence on mood and clinical improvement, observed when using psychobiotics as an adjuvant treatment of depression, as well as monotherapy. Conclusion. Further research is needed in this area, especially in humans, to gain a deeper understanding of the role of the gut microbiota in depression and the promising use of psychobiotics for its treatment.