European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/9493

Przeglądaj

Aktualnie wyświetlane 1 - 20 z 32

Speech development delay in autism spectrum disorder – the perspective of using the “Talk To Me” speech therapy application
(Publishing Office of the University of Rzeszow, 2023-12) Warmbier, Wojciech A.; Perenc, Lidia; Piwoński, Paweł; Podgórska-Bednarz, Justyna
Introduction and aim. The paper aims to present the prospects of using the „Talk To Me” application in the case of a child with this neurodevelopmental disorder. Description of the case. The subject of the study was a 53-month-old boy who did not communicate verbally, but behaved forcefully. A child underwent a speech therapy using the „Talk To Me” application for a period of 12 weeks. The scale of acquiring language skills in the field of communication competence was used to monitor the progress of therapy. In the analyzed period, a decrease in the score on the scale from 23 to 15 points was observed, which means a result indicating an improvement in the communication sphere. The use of a newly developed therapeutic tool was an important motivational factor and, in the opinion of the boy’s mother, significantly influenced the progress in therapy, which had not been observed before using a conventional approach. Conclusion. The „Talk To Me” application is a therapeutic tool with potential effectiveness in the case of speech delays in children with autism spectrum disorder, and it is also compatible with behavioral therapy, a widely used therapeutic method with proven effectiveness in autism spectrum disorder.
Secondary Fahr’s syndrome mimicking meningoencephalitis
(Publishing Office of the University of Rzeszow, 2023-12) Vamshikrishnapatel, Kotha; Kumar, Vijay; Biswas, Ratnadeep; Ojha, Vishnu S; Hegde, Aniketh V.
Introduction and aim. Fahr’s disease is a rare neurological disorder characterized by bilateral basal ganglia calcifications. The aim of this report is to highlight a case of Fahr’s disease with atypical features such as neck rigidity and peripheral nerve involvement. Description of the case. Here, we present the case of a South Asian patient with secondary Fahr’s disease whose clinical presentation mimicked that of meningoencephalitis. The patient had neurological and neuropsychiatric symptoms along with abnormal body movements. She also had restricted neck mobility. Computed tomography of the head revealed bilateral dense calcifications in the basal ganglia suggestive of Fahr’s syndrome. Investigations revealed severe hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels, which led to the identification of hypoparathyroidism as the underlying cause. The presence of pre-existing epilepsy and neck rigidity made the diagnosis difficult. The relatively rapid development of symptoms along with the presence of peripheral nerve involvement made this case even more unique. Calcium levels were corrected, and there was a marked symptomatic improvement. Conclusion. Neck rigidity and restricted neck mobility may be present in cases of Fahr’s syndrome due to calcifications of the nuchal ligament or other spinal ligaments and thus must be differentiated from meningoencephalitis. Although the symptoms of Fahr’s syndrome are generally limited to the central nervous system, there may be involvement of the peripheral nerves as well.
Demystifying the intricacies – a rare report of two cases of biradicular permanent mandibular lateral incisor and their endodontic management
(Publishing Office of the University of Rzeszow, 2023-12) Makkar, Sameer; Gupta, Sandeep; Singh, Aiana; Rohilla, Smriti
Introduction and aim. One of the imperative reasons for endodontic failure is an extra or missed root and root canals. Permanent mandibular lateral incisors generally present as monoradicular tooth with one or two canals, but aberrancies in the form of extra root are also rarely seen. There is insufficiency in the literary work regarding the presence of an extra root in permanent mandibular lateral incisor. We hereby report two illustrious cases of biradicular permanent mandibular lateral incisors and their endodontic management and brief review regarding the case reports published so far regarding the existence of an extra root in permanent mandibular lateral incisor in the literature. Also, we intend to apprise the scientific documentation with the aforementioned. Description of the cases. Case 1. A twenty-two-year-old male patient of Indian origin was referred to endodontic clinic for intentional root canal therapy. Pre-operative radiograph revealed 32 exhibited aberrancy in the form of an extra root, with normal periodontal structures and bone architecture. Case 2. A sixty-two-year-old male patient came to the Department of Conservative Dentistry and Endodontics with the chief complaint of pain in the lower anterior tooth region. Radiographic examination revealed root caries on the mesial side and two roots with two canals with bifurcation at the level of middle third of root. Conclusion. Clinicians should be well prepared in advance for management of any anatomical aberrancy in their clinical practice by having a scrupulous knowledge of root canal system.
Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond
(Publishing Office of the University of Rzeszow, 2023-12) Singh, Dhishank; Kaur, Ginpreet; Chintamaneni, Meena; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh
Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases. Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar. Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation. Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.
The gut microbiota in development and treatment of depression
(Publishing Office of the University of Rzeszow, 2023-12) Wilczek, Natalia; Bogucka, Julia; Brzyska, Anna; Sielwanowska, Wiktoria; Syzdoł, Bartłomiej; Piecewicz-Szczęsna, Halina
Introduction and aim. Nowadays, almost 4% of people in the world suffer from depressive disorders, and the forecasts of further increase in incidence are alarming. The disease is debilitating and can lead to suicide, and available treatments are still imperfect. The aim of the study was to review the literature and present the potential role of the gut microbiota in the development of depression and to consider the use of prebiotics and probiotics as one of the therapeutic options in this disease. Material and methods. Review of articles published on PubMed since 2015. Analysis of the literature. The available reports point to a relationship between disturbances in the composition of the intestinal flora and the development of depressive disorders. In addition, more and more studies indicate the benefits of the influence on mood and clinical improvement, observed when using psychobiotics as an adjuvant treatment of depression, as well as monotherapy. Conclusion. Further research is needed in this area, especially in humans, to gain a deeper understanding of the role of the gut microbiota in depression and the promising use of psychobiotics for its treatment.
Hematopoietic stem cell transplantation in the treatment of HIV infection – comparison of “Berlin patient”, “London patient” and “Dusseldorf patient”
(Publishing Office of the University of Rzeszow, 2023-12) Brzyska, Anna; Bogucka, Julia; Bojarska, Małgorzata Kinga; Domańska, Natalia Anna; Piecewicz-Szczęsna, Halina
Introduction and aim. Human Immunodeficiency Virus-1 (HIV-1) remains one of the major issues in global public health. The standard therapy for HIV-1 positive patients includes using antiretroviral therapy (ART). These medications ensure suppression of viral replication but do not lead to a cure for the patient. The aim of this study was to present hematopoietic stem cell transplantation (HSCT) as a malignant treatment method which led to cure for three HIV-1 positive patients. Material and methods. Literature available in April 2023 was searched by using the PubMed and Google Scholar databases. Articles were selected using the following words: HIV, AIDS, HSCT therapy, ART therapy. Analysis of the literature. In each case of these described HSCT, the donor of hematopoietic stem cells had a homozygous mutation in the HIV co-receptor CCR5 (CCR5Δ32/Δ32). This mutation leads to a permanent lack of the protein and prevents penetration of virus by using this receptor. After transplantation, all of these 3 patients remained virus-free despite discontinuation of ART therapy. Conclusion. More research is needed to reduce the risk of using HSCT and perhaps in the future be able to use this therapy in all HIV-infected people.
Ascorbic acid in cancer management – time for a second look
(Publishing Office of the University of Rzeszow, 2023-12) Ogochukwu, Izuegbuna
Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.
Tuberculosis epidemic in India – a systematic review
(Publishing Office of the University of Rzeszow, 2023-12) Deotale, Pranay; Mondal, Nitish
Introduction and aim. India, accounting for approximately 26% of the global tuberculosis (TB) burden with a significant proportion of 0.11 million (6%) pediatric TB cases. The goal of this systematic review paper is to provide a thorough analysis of the TB epidemic in India, including information on the severity of the illness and challenges associated with diagnosis and treatment, the risk factors for transmission and progression of the disease, and the advancements and difficulties encountered in efforts to control at community level. Material and methods. The terms “Tuberculosis in India,” “Drug-Resistant Tuberculosis,” “Tuberculosis and Associated Co-morbidities,” “Diagnosis of Tuberculosis,” “Prevention of Tuberculosis,” and “Treatment of Tuberculosis’’, keywords were used to search in number of international electronic databases, including “Google Scholar,” “PubMed,” and “DOAJ.” Analysis of the literature. Diagnosis and treatment of TB are significantly complicated by co-morbid condition such includes alcoholism, diabetes, HIV, undernutrition, diabetes and HIV. In addition, there may be treatment delays, and the extra-pulmonary or drug-resistant TB due to ignorance, misunderstandings, and lack of education among TB patients, and medical professionals, which ultimately increases morbidity and mortality. Conclusion. Poverty, undernutrition, inadequate healthcare infrastructure, and co-morbidities, which frequently complicate TB diagnosis and treatment, must be addressed in addition to the critical need to prioritize TB research and development.
Evaluation of the antioxidant activity of Berberis jaeschkeana C. K. Schneid. fruits using the ABTS assay
(Publishing Office of the University of Rzeszow, 2023-12) Och, Anna; Ćwikła, Agata; Orzechowska, Karolina; Cwener, Anna
Introduction and aim. The assessment of the antioxidant activity of plant extracts is an important research direction in the search for new chemopreventive substances. The aim of this study was to demonstrate the antioxidant potential of the methanol extract of Berberis jaeschkeana C. K. Schneid fruit. Material and methods. Spectrophotometric tests were carried out: testing of the total content of polyphenols (TPC) in extracts, testing of the total content of flavonoids (TFC) in extracts. Antiradical activity was determined using the improved ABTS+• decolorization test with modifications. Results. TPC extracts was determined at the level of 43.52±2.37 mg/g, while TFC extracts was determined at the level 6.08±0.48 mg/g. The ABTS activity test showed 31.15 mg/g expressed as mg Trolox per g of dry extract. Conclusion. It was assessed that the methanolic extract of the fruit of Berberis jaeschkeana C. K. Schneid. has an antioxidant properties, what makes it a potential chemopreventive agent in civilizational diseases.
Percutaneous sclerotherapy using polidocanol in the treatment of aneurysmal bone cysts of extremities – a report of 28 consecutive cases
(Publishing Office of the University of Rzeszow, 2023-12) Harshwal, Raj Kumar; Kumawat, Email src Kaushal Kishore; Saini, Narender; Sehrawat, Manisha; Meena, Devi Sahay
Introduction and aim. Aneurysmal bone cysts (ABC) are aggressive benign lesions with high rates of recurrence rendering its treatment uniquely challenging. We report the outcome in 28 consecutive patients of ABC of extremities treated with percutaneus sclerotherapy using 3% polidocanol over a period of 5 years. Material and methods. In biopsy proven 28 ABC cases, Injection polidocanol 3% was used as sclerosing agent under fluoroscopy guidance. Injections were repeated at 6-week intervals till complete healing of cysts. Radiological and functional results were assessed by Rastogi et al. criteria, VAS score and Enneking scoring method. Results. 25 out of 26 patients (89.28%) displayed good clinical response with an average 2.56 injections per patients. The mean follow-up period was 17.04±7.08 months. Reduction in cyst volume (mean 6.86±1.48 to 0.71±1.48.) and VAS score (mean 6.72±1.51 to 0.56±1.08) and improvement in Enneking score (17.35±3.14 to 28.92±1.35) at last follow up was significant. No recurrence was reported during the study period. Treatment failure, skin sclerosis and infection were reported in one case each. Conclusion. sclerotherapy with polidocanol 3% for primary ABC is safe and effective alternate method with advantage of no surgical morbidity, having better functional score with lesser recurrence and minimal complications.
Characterization of SUS-treated amputees at the Itanhaém Municipal Rehabilitation Center from 2012 to 2020
(Publishing Office of the University of Rzeszow, 2023-12) Artioli, Dérrick Patrick; Bertolini, Gladson Ricardo Flor
Introduction and aim. Analyzing the factors related to amputations and understanding which factors are changeable can assist in the development of public policies for the prevention and education of the population. Objective: To describe the main etiological characteristics and symptoms after amputation in the Unified Health System (Sistema Único de Saúde – SUS) patients in order to contribute to the information for treatment planning by the multiprofessional team for these patients. Material and methods. Retrospective study from 2012 to 2020, evaluating data from all amputation cases seen at the Itanhaém Municipal Rehabilitation Service, SP. Results. 76 cases were studied, mostly middle-aged men, Caucasian, smokers, hypertensive, type II diabetics, some with dyslipdemia, cardiopathies, and the main cause of amputation was infection after wound. Conclusion. The population needs to be warned about the risk of amputation due to infected wounds in patients with difficulty in controlling their comorbidities. Patients who have undergone amputation, should be oriented towards an early utilization of rehabilitation services, and municipalities should prepare their medical and rehabilitation professionals for the treatment of characteristic symptoms that amputees report and prosthetization.
Utilizing machine learning to create a blood-based scoring system for sepsis detection
(Publishing Office of the University of Rzeszow, 2023-12) Aref, Sadik
Introduction and aim. Sepsis, a disease caused by inflammation as a response to infection, often goes undiagnosed due to its heterogeneity and lack of a single diagnostic test. Current sepsis detection scoring systems have low sensitivity and utilize biomarkers that are difficult to obtain from a single test. The goal of this research is to create a scoring system that outperforms current industry standards by utilizing blood-based biomarkers readily available in hospital settings. Material and methods. Machine learning algorithms were run through Google Colab using Extreme Gradient Boost classifier. The dataset was obtained from NCBI website containing electronic hospital records of intensive care patients. A multivariate linear regression was applied to the dataset to determine statistically significant biomarkers in the detection of sepsis, and their β coefficients. Then, validation testing was performed, and the performance was compared to other scoring systems. Results. This experiment reveals that a sepsis detection system that utilizes procalcitonin, white blood cells, C-reactive protein, neutrophil to lymphocyte ratio, and albumin can outperform other biomarkers and scoring systems with high sensitivity at a recall score of 0.7922. Conclusion. These results demonstrate the potential of utilizing a blood-based scoring system for sepsis detection within hospital settings.
Nursing students’ awareness of health-promoting lifestyle profile and sustainable development goals – a quasi-experimental study
(Publishing Office of the University of Rzeszow, 2023-12) Dolu, lknur; Bozkurt, Feyza Demir
Introduction and aim. Health promotion is one of the common elements of sustainable development goals. The aim of this study was to identify the impact of “Healthy Life and Environment” course on nursing student’s awareness of sustainable development and healthy life, and health-promoting lifestyle behaviours. Material and methods. A pre-, and post-test control group quasi-experimental research design was used. One nursing department located in Nortwest Blacksea region, Turkey. A total of 160 nursing students pursuing bachelor nursing programs. Students from first and second years who enrolled in the “Healthy Life and Environment” course assigned to intervention group, those who did not attend the course assigned to control group. Results. Female students had higher level of HPLP II and SDA than male. SDA had a weak correlation with HLA and a very week correlation with HPLP II at baseline. Intervention group had an improvement of .03 points in HPLP II, no change in HLA, and a slight improvement of .01 points in SDA, however these differences were not statistically important. Conclusion. The results of our study highlighted that nursing curricula need to be modified to incorporate sustainable development methodology using student-centered learning.
Determination of attitudes and practices of nurses working in the psychiatry clinic towards physical health care of individuals with severe mental illness
(Publishing Office of the University of Rzeszow, 2023-12) Kurtoğlu, Hande Yardımcı; Çelik İnce, Sevecen
Introduction and aim. Individuals with severe mental illness experience more physical health problems than the general population and their life expectancy may be shorter. Therefore, the physical care provided to these patients is very important.This study aims to examine the attitudes, practices, and training needs of nurses working in psychiatry clinics towards physical health care of individuals with severe mental illness. Material and methods. This descriptive, cross-sectional study collected data from 139 nurses in psychiatry clinics using the Personal Information Form and Physical Health Attitude Scale. Results. This study found that nurses often provide physical healthcare as part of their routine care for individuals with severe mental illness. However, the study also revealed that nurses require additional education to better provide this type of care. Despite this, the nurses generally displayed a positive attitude towards physical health. The average total score on the physical health attitude scale was 80.33±10.14. Conclusion. The study concluded that nurses have a positive attitude towards physical health in general. The role of nurses working in psychiatry clinics is crucial in evaluating and caring for physical health of individuals with severe mental illness, as it is an important aspect of holistic nursing care. It is necessary to make nurses aware of their shortcomings in providing physical health care and support them in improving in this area.
The investigation of the impact of education on sexual health/reproductive health knowledge levels of nurses and midwives in extraordinary situations – evidence from Turkey
(Publishing Office of the University of Rzeszow, 2023-12) Cirban Ekrem, Ebru; Kuş, Tuğçe; Erkmen, Emir; Dursun, Nisanur
Introduction and aim. In extraordinary situations, sexual/reproductive health services are very important for the health of the whole society, especially women and children. The aim of this study is to assess the impact of training provided on sexual health/reproductive health during extraordinary situations on the knowledge levels of nurses and midwives. Material and methods. The research was conducted using a single-group pre-test-post-test follow-up test measurement quasi-experimental design. It was completed between November 2021–June 2022 with 140 participants working in a province in Turkey. The data were collected with the “Descriptive Information Form” and the “Sexual Health and Reproductive Health Knowledge Assessment Form for Extraordinary Situations”. Training was given with the Sexual Health/Reproductive Health Training Booklet for Extraordinary Situations. Results. It was found that the participants scored 20.82±4.47 on the Sexual Health and Reproductive Health Knowledge Assessment Form for Extraordinary Situations in the pre-test, 27.63±2.67 in the post-test, and 27.07±3.46 in the follow-up test. As a result of the training, it was determined that the difference between the scores they got from the Sexual Health and Reproductive Health Knowledge Assessment Form for Extraordinary Situations was due to the pre-test (p<0.05). Conclusion. In the study, the participants scored above the average in the pre-test, while they achieved significantly higher scores in the post-test and follow-up test. This shows that the training given to nurses and midwives is effective.
Fall risk and frailty level in older adults admitted to the emergency department with a complaint of falling
(Publishing Office of the University of Rzeszow, 2023-12) Çelik, Sevim; Uğur, Neşe; Karahan, Elif; Dolu, İlknur
Introduction and aim. Falls are the second leading cause of unintentional death in the world. The study was conducted to examine the risk of falls and levels of frailty in older adult patients admitted to the emergency department due to fractures, as well as to identify the factors that influence fall risk and frailty levels. Material and methods. This cross-sectional and correlational study conducted with 155 older patients. Data collected by the patient information form, Itaki Fall Risk Scale and Edmonton Frail Scale. Results. Patients diagnosed with fracture in the emergency department had a high risk of falling with a mean score of 9.55±3.84.70.3% of the patients were frail. The one-third (30.3%) had severe frailty. There was a moderate positive correlation between the risk of falling and the mean frailty score of the older adult patients (p<0.001). Conclusion. The study showed that older adults admitted to the emergency department due to falls are at high risk of falling and the majority of them are frail. Early determination of fall risk and frailty levels in the older adults with a history of falling, prevention of falls and fractures due to falls will be beneficial in increasing the quality of life of the older adults.
Prevalence, prescription patterns, and quality of life of anaemia in adults with chronic renal disease
(Publishing Office of the University of Rzeszow, 2023-12) Sandeep, Akkam; Elumalai, Karthikeyan; Williams, Helen; Salkapuram, Sunilkumar; Anandakumar, Shanmugam; Srinivasan, Sivaneswari
Introduction and aim. Anaemia is a chronic kidney disease (CKD) condition characterised by a decline in glomerular filtration rate (GFR) and impaired kidney function. The aim of this study was to assess the prevalence, prescribing patterns, and quality of life of anaemia in patients with chronic renal disease who were adults (>18 years of age) at a tertiary care hospital. Material and methods. Data on demographic characteristics, laboratory results, medication prescriptions, and quality of life assessments were collected. Statistical tests were performed to determine associations between anaemia prevalence and factors like age, gender, and CKD stage. The study included 132 patients, with a gender distribution of 89 men and 43 women. Results. The most frequently prescribed drugs are epoetin (15.06%), multivitamins (14.82%), iron (10.65%), folic acid (10.22%), calcium carbonate (8.17%), calcitriol (5.6%), and omeprazole (4.22%). The cardiovascular system, blood disorders, and blood-producing organs come after the gastrointestinal tract and metabolism in the first anatomical level of the ATC classification. Conclusion. It suggests hospital audits and recommendations for improved prescription practices. Further investigation into anaemia causes and drug class appropriateness is needed, and implementing improvements could potentially improve health outcomes.
Manifestations of post-traumatic stress in military personnel after participating in hostilities in the Russian-Ukrainian war
(Publishing Office of the University of Rzeszow, 2023-12) Prykhodko, Ihor; Matsehora, Yanina; Kryvokon, Nataliya; Hunbin, Konstantin; Kovalchuk, Oleksandr; Antusheva, Nataliia; Filonenko, Lesia
Introduction and aim. Since the beginning of the Russian-Ukrainian war, many Ukrainian military personnel began to show post-traumatic stress (PTS). The purpose of the article is to identify the features of PTS exhibited in different age groups in trauma-exposed military personnel during their participation in the psychological recovery program (“Invincibility Program”). Material and methods. Ukrainian Defense Forces military personnel (n=546 males, between 20 and 60 years of age) participated in this study. All participants were divided into three age groups. Determination of the features of PTS in military personnel was carried out using psychodiagnostic tests. Results. In each age group, more than half of the participants in the “Invincibility Program” had PTS characteristics such as the sub-threshold or clinical manifestations of PTSD, adjustment disorders, low resilience to combat mental trauma, and various sleep disorders combined with somatic complaints. The data showed higher features of PTS in the younger participants and they decreased in both the 2 older sets of participants. Conclusion. The age-related features of the manifestation of PTS in military personnel must be taken into account when developing psychological recovery programs: for younger participants, such events should be carried out longer and more intensively.
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
(Publishing Office of the University of Rzeszow, 2023-12) Omon, Emmanuel Akokhamen; Ajayi, Olawale David
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
The use of the “Talk To Me” application in the therapy of speech development delays
(Publishing Office of the University of Rzeszow, 2023-12) Warmbier, Wojciech A.; Podgórska-Bednarz, Justyna; Gagat-Matuła, Anna; Perenc, Lidia
Introduction and aim. Computer techniques are increasingly used in speech therapy. The aim of the work is to present the results of the preliminary evaluation of the new “Talk To Me” application and its functionality in the treatment of speech development delays. Material and methods. The study was conducted in 3 groups of children: the study group with the use of the “Talk To Me” application, the conventional therapy group and the control group - in the case of both groups with the intervention, additional reinforcements were used. All children included in the project showed delays in speech development. The recorded age of children in all analyzed groups ranged from 2 to 6 years. In order to verify language progress, the Scale of Language Skills Acquisition in the Field of Communication Competence was used. Results. Acquisition of language skills varies depending on the group affiliation. The analysis of simple main effects for the time of measurement showed that in each group the differences between successive measurements turned out to be significant. In the study group, the increase in language skills differs from the other two groups (p<0.001). However, there is no difference between the groups with conventional and control therapy (p=1.00). Conclusion. Analysis of the research results allows us to conclude that the “Talk To Me” application is a tool that significantly affects the speed of therapy progress in the case of speech development delays concerning communicative competence.

Przeglądaj

Ostatnio nadesłane materiały