European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/9493

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A study on the mycobacterial burden and phenotypic drug resistance pattern with reference to the GeneXpert Cycle Threshold values in pulmonary tuberculosis
(Publishing Office of the University of Rzeszow, 2023-12) Kashyap, Bineeta; Sarkar, Krishna; Singh, Kapil; Hyanki, Puneeta
Introduction and aim. Tuberculosis (TB) remains a significant global health challenge. Early and accurate diagnosis is crucial to prevent further transmission. The present study aimed to correlate cycle threshold values with smear microscopy and culture positivity, and determine cut-off cycle threshold values for levels of smear grade and culture positivity. Material and methods. Forty presumptive cases of pulmonary TB were included and subjected to Ziehl- Neelsen stain, culture on Lowenstein Jensen media, CBNAAT and drug susceptibility testing for first line anti-tubercular drugs. Results. Our study predicts 3+, 2+, and 1+ sputum smear grade at a cut-off of Ct value ≤ 16.74, ≤19.68, and ≤ 22.32 respectively. A strong positive correlation was found between time to culture positivity and Ct value. A cut-off of Ct value ≤22.32 predicts culture positivity with a sensitivity of 92%, and a specificity of 67%. None of the isolates showed rifampicin resistance by 1% proportion method. Conclusion. Understanding the appropriate utilization of CBNAAT Ct values and their correlation with smear microscopy grade, culture, and drug susceptibility testing can assist clinicians in early identification and prompt initiation of appropriate treatment. This knowledge can contribute to the prevention of drug resistance, reduced transmission, and a decreased disease burden associated with TB.
An in vitro study for the evaluation of morphological and biochemical characteristics of absorbable sutures coated with genistein and nicotine
(Publishing Office of the University of Rzeszow, 2023-12) Chopra, Aditi; Cecil, Anju; Eshwaramoorthy, Rajalaksmanan; John, Rubin S.
Introduction and aim. Inflammation, cell proliferation, matrix deposition, and tissue remodeling are all elements of the well-structured and well-coordinated process of wound repair. The aim of this study was to analyze the effect of genistein and nicotine on polyglycolic acid (PGA) and vicryl sutures. Material and methods. Genistein and nicotine were isolated and solution was prepared and the suture material PGA and vicryl were immersed in the solution and dried. They were tested for their tensile strength and degradation values after immersion in artificial saliva (on the first day and on the 14th day). The sutures were also seen under a scanning electron microscope (SEM) for its uniform coating and the mixture formulation of genistein and nicotine were tested for their anti-inflammatory and antioxidant activity using protein denaturation assay and 2,2-diphenyl-1-picrylhydrazyl assay respectively. Results. Nicotine has a high anti-inflammatory activity on the suture material, whereas Genistein has an insignificant anti-inflammatory effect. The mixture formulation has a relatively similar anti-inflammatory effect when compared to the control. The SEM analysis shows a uniform coating of the formulation on the PGA and vicryl sutures. In comparison, PGA has shown lesser tensile strength and hence higher degradation ability. Conclusion. Nicotine and Genistein affect the tensile strength and degradation properties of the sutures.
Ascorbic acid in cancer management – time for a second look
(Publishing Office of the University of Rzeszow, 2023-12) Ogochukwu, Izuegbuna
Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.
Challenges of the COVID-19 pandemic for children and their families during home quarantine in Turkey
(Publishing Office of the University of Rzeszow, 2023-12) Aydın, Bahise; Çalbayram, Nazan Çakırer; Altundağ, Sebahat
Introduction and aim. The COVID-19 pandemic has caused significant changes in human life. As a result of these changes, it is important to determine the effects on the child and family life. This study was conducted to determine the challenges experienced by children and their families while home quarantine in the pandemic. Material and methods. The study was conducted with parents who had children aged 6-18, use social media, and willing to participate in the study. A total of 450 parents participated in the study. Online survey was used. Results. It was determined that some of parental daily activities decreased (doing sports, communicating with friends, engaging in hobbies) and some of them increased (personal hygiene, internet, and playing games with their children). The decreased daily activities of children (doing sports and communicating with friends) and increased activities (eating, personal hygiene, internet, and social media use, playing with toys and technological devices) were detected. There was an increase in some of the family activities (watching movies, playing games, and studying). Conclusion. It was determined that the home quarantine in the pandemic led to some negative changes in the daily living habits, lifestyles, and feelings of the family.
Characterization of SUS-treated amputees at the Itanhaém Municipal Rehabilitation Center from 2012 to 2020
(Publishing Office of the University of Rzeszow, 2023-12) Artioli, Dérrick Patrick; Bertolini, Gladson Ricardo Flor
Introduction and aim. Analyzing the factors related to amputations and understanding which factors are changeable can assist in the development of public policies for the prevention and education of the population. Objective: To describe the main etiological characteristics and symptoms after amputation in the Unified Health System (Sistema Único de Saúde – SUS) patients in order to contribute to the information for treatment planning by the multiprofessional team for these patients. Material and methods. Retrospective study from 2012 to 2020, evaluating data from all amputation cases seen at the Itanhaém Municipal Rehabilitation Service, SP. Results. 76 cases were studied, mostly middle-aged men, Caucasian, smokers, hypertensive, type II diabetics, some with dyslipdemia, cardiopathies, and the main cause of amputation was infection after wound. Conclusion. The population needs to be warned about the risk of amputation due to infected wounds in patients with difficulty in controlling their comorbidities. Patients who have undergone amputation, should be oriented towards an early utilization of rehabilitation services, and municipalities should prepare their medical and rehabilitation professionals for the treatment of characteristic symptoms that amputees report and prosthetization.
Demystifying the intricacies – a rare report of two cases of biradicular permanent mandibular lateral incisor and their endodontic management
(Publishing Office of the University of Rzeszow, 2023-12) Makkar, Sameer; Gupta, Sandeep; Singh, Aiana; Rohilla, Smriti
Introduction and aim. One of the imperative reasons for endodontic failure is an extra or missed root and root canals. Permanent mandibular lateral incisors generally present as monoradicular tooth with one or two canals, but aberrancies in the form of extra root are also rarely seen. There is insufficiency in the literary work regarding the presence of an extra root in permanent mandibular lateral incisor. We hereby report two illustrious cases of biradicular permanent mandibular lateral incisors and their endodontic management and brief review regarding the case reports published so far regarding the existence of an extra root in permanent mandibular lateral incisor in the literature. Also, we intend to apprise the scientific documentation with the aforementioned. Description of the cases. Case 1. A twenty-two-year-old male patient of Indian origin was referred to endodontic clinic for intentional root canal therapy. Pre-operative radiograph revealed 32 exhibited aberrancy in the form of an extra root, with normal periodontal structures and bone architecture. Case 2. A sixty-two-year-old male patient came to the Department of Conservative Dentistry and Endodontics with the chief complaint of pain in the lower anterior tooth region. Radiographic examination revealed root caries on the mesial side and two roots with two canals with bifurcation at the level of middle third of root. Conclusion. Clinicians should be well prepared in advance for management of any anatomical aberrancy in their clinical practice by having a scrupulous knowledge of root canal system.
Determination of attitudes and practices of nurses working in the psychiatry clinic towards physical health care of individuals with severe mental illness
(Publishing Office of the University of Rzeszow, 2023-12) Kurtoğlu, Hande Yardımcı; Çelik İnce, Sevecen
Introduction and aim. Individuals with severe mental illness experience more physical health problems than the general population and their life expectancy may be shorter. Therefore, the physical care provided to these patients is very important.This study aims to examine the attitudes, practices, and training needs of nurses working in psychiatry clinics towards physical health care of individuals with severe mental illness. Material and methods. This descriptive, cross-sectional study collected data from 139 nurses in psychiatry clinics using the Personal Information Form and Physical Health Attitude Scale. Results. This study found that nurses often provide physical healthcare as part of their routine care for individuals with severe mental illness. However, the study also revealed that nurses require additional education to better provide this type of care. Despite this, the nurses generally displayed a positive attitude towards physical health. The average total score on the physical health attitude scale was 80.33±10.14. Conclusion. The study concluded that nurses have a positive attitude towards physical health in general. The role of nurses working in psychiatry clinics is crucial in evaluating and caring for physical health of individuals with severe mental illness, as it is an important aspect of holistic nursing care. It is necessary to make nurses aware of their shortcomings in providing physical health care and support them in improving in this area.
Evaluation of salivary alpha amylase activity in smokers with periodontitis, Khartoum state, 2023
(Publishing Office of the University of Rzeszow, 2023) Allah, Fatima Abd Alwhab Awad; Ahmed, Hafsa Ahmed Elrheima
Introduction and aim. Smoking widely affect oral health, including its role in the development of periodontitis. Saliva contains an antioxidant system and various enzymes. The study was designed to evaluate the activity of salivary alpha amylase among individuals who smoke and have periodontitis. Material and methods. A total of 100 participants were included, with 50 cases (cigarette smokers with periodontitis) and the remaining 50 nonsmokers with healthy periodontium as the control group. Saliva samples were collected to measure salivary alpha amylase activity. Results. Smokers with periodontitis had significantly higher levels of salivary alpha amylase compared to the control group (177.96±14.5 vs 94.04±19.6 IU/mL, p<0.001). Additionally, there was a weak negative correlation between the level of alpha amylase and the age of the patients (p=0.01, r=0.376). However, no correlation was found between the level of alpha amylase and the duration of smoking (p=0.584, r=0.079). Conclusion. There is a significant increase in salivary alpha amylase levels among smokers with periodontitis. No correlation was found between age and salivary alpha amylase levels. However, a weak positive correlation was observed between the duration of smoking and salivary alpha amylase activity.
Evaluation of the antioxidant activity of Berberis jaeschkeana C. K. Schneid. fruits using the ABTS assay
(Publishing Office of the University of Rzeszow, 2023-12) Och, Anna; Ćwikła, Agata; Orzechowska, Karolina; Cwener, Anna
Introduction and aim. The assessment of the antioxidant activity of plant extracts is an important research direction in the search for new chemopreventive substances. The aim of this study was to demonstrate the antioxidant potential of the methanol extract of Berberis jaeschkeana C. K. Schneid fruit. Material and methods. Spectrophotometric tests were carried out: testing of the total content of polyphenols (TPC) in extracts, testing of the total content of flavonoids (TFC) in extracts. Antiradical activity was determined using the improved ABTS+• decolorization test with modifications. Results. TPC extracts was determined at the level of 43.52±2.37 mg/g, while TFC extracts was determined at the level 6.08±0.48 mg/g. The ABTS activity test showed 31.15 mg/g expressed as mg Trolox per g of dry extract. Conclusion. It was assessed that the methanolic extract of the fruit of Berberis jaeschkeana C. K. Schneid. has an antioxidant properties, what makes it a potential chemopreventive agent in civilizational diseases.
Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond
(Publishing Office of the University of Rzeszow, 2023-12) Singh, Dhishank; Kaur, Ginpreet; Chintamaneni, Meena; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh
Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases. Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar. Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation. Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.
Fall risk and frailty level in older adults admitted to the emergency department with a complaint of falling
(Publishing Office of the University of Rzeszow, 2023-12) Çelik, Sevim; Uğur, Neşe; Karahan, Elif; Dolu, İlknur
Introduction and aim. Falls are the second leading cause of unintentional death in the world. The study was conducted to examine the risk of falls and levels of frailty in older adult patients admitted to the emergency department due to fractures, as well as to identify the factors that influence fall risk and frailty levels. Material and methods. This cross-sectional and correlational study conducted with 155 older patients. Data collected by the patient information form, Itaki Fall Risk Scale and Edmonton Frail Scale. Results. Patients diagnosed with fracture in the emergency department had a high risk of falling with a mean score of 9.55±3.84.70.3% of the patients were frail. The one-third (30.3%) had severe frailty. There was a moderate positive correlation between the risk of falling and the mean frailty score of the older adult patients (p<0.001). Conclusion. The study showed that older adults admitted to the emergency department due to falls are at high risk of falling and the majority of them are frail. Early determination of fall risk and frailty levels in the older adults with a history of falling, prevention of falls and fractures due to falls will be beneficial in increasing the quality of life of the older adults.
Genetic variants of the glucagon-like receptor-1 in obesity
(Publishing Office of the University of Rzeszow, 2023-12) Nikulina, Anna
Introduction and aim. Dysfunction of the glucagon-like peptide 1 (GLP-1)/GLP-1 receptor (GLP-1R) axis promotes obesity and metabolic disorders. The aim was to study the associations of the single nucleotide variants (SNV) GLP1R gene with proinflammatory cytokines and metabolic disorders in children with various obesity phenotypes. Material and methods. 252 children with obesity aged 6-18 years were examined. The first group (n=152) was represented by children with metabolically unhealthy obesity (MUO). The second group (n=100) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 52 children. Results. An association with the development of obesity was noted for T alleles rs61754624 (t=3.33) and rs10305457 (t=2.06); with MUO – for C alleles rs1042044 (t=2.23), rs1126476 (t=2.63), rs2235868 (t=2.82); T alleles rs61754624 (t=3.33), rs10305457 (t=2.06) GLP1R, p<0.05. In the MHO group, a correlation was found with the levels of pro-inflammatory markers IL-1β, IL-6 in the presence of the GA genotype SNV rs3765468; with hyperglycemia - GA genotype SNV rs6923761, CC genotype SNV rs1042044, AA rs6918287; hyperinsulinemia - GA genotype SNV rs3765468, GG rs10305421; triglyceridemia - AA rs6918287 of GLP1R. Conclusion. SNV rs1042044, rs3765468, rs6923761, s6918287, and rs rs10305421 GLP1R are associated with the development of MUO in individuals with MHO.
Haemocytometric profile and plasma levels of selected cytokines in patients at various stages of cervical cancer
(Publishing Office of the University of Rzeszow, 2023-12) Jimoh, Mutiu Alani; Onifade, Abdulfatah Adekunle; Abbiyesuku, Fayeofori Mpakaboari; Edem, Victory Fabian; Rahamon, Sheu Kadiri; Arinola, Olatunbosun Ganiyu
Introduction and aim. Reports have shown that there is alteration in haematological and inflammatory processes in patients with cervical cancer. However, there is the dearth of information on the pattern of alteration in Nigerian patients with cervical cancer at various stages of the disease. Therefore, haemocytometric profile and plasma levels of interleukin-6 (IL-6) and IL-12 were determined in Nigerian patients with cervical cancer at various stages of the disease. Material and methods. Eighty-nine adults consisting of 49 patients with cervical cancer and 40 apparently healthy controls were enrolled into this study. Haemocytometric profile was determined using automated haematology analyzer while the plasma levels of interleukin-6 (IL-6) and IL-12 were determined using ELISA. Results. Of the participants with cervical cancer, 6.12%, 24.49%, 53.06% and 16.33% were in stages I, II, III and IV respectively. The mean plasma IL-6 level was significantly higher in patients at stage IV of the cancer compared with those in stages I, II and III. No significant differences were observed in the mean plasma IL-12 level, and the haemocytometric profile when patients in different stages of the cancer were compared with one another. Plasma IL-6 had significant positive correlation with the lymphocytes count and cancer stage but had significant negative correlation with packed cell volume (PCV), haemoglobin and total white blood cells count (WBC) in patients with cervical cancer. Conclusion. Interleukin-6 appears to play an important role in the progression of cervical cancer and could be involved in cervical cancer-associated alteration in haemocytometric profile.
Hematopoietic stem cell transplantation in the treatment of HIV infection – comparison of “Berlin patient”, “London patient” and “Dusseldorf patient”
(Publishing Office of the University of Rzeszow, 2023-12) Brzyska, Anna; Bogucka, Julia; Bojarska, Małgorzata Kinga; Domańska, Natalia Anna; Piecewicz-Szczęsna, Halina
Introduction and aim. Human Immunodeficiency Virus-1 (HIV-1) remains one of the major issues in global public health. The standard therapy for HIV-1 positive patients includes using antiretroviral therapy (ART). These medications ensure suppression of viral replication but do not lead to a cure for the patient. The aim of this study was to present hematopoietic stem cell transplantation (HSCT) as a malignant treatment method which led to cure for three HIV-1 positive patients. Material and methods. Literature available in April 2023 was searched by using the PubMed and Google Scholar databases. Articles were selected using the following words: HIV, AIDS, HSCT therapy, ART therapy. Analysis of the literature. In each case of these described HSCT, the donor of hematopoietic stem cells had a homozygous mutation in the HIV co-receptor CCR5 (CCR5Δ32/Δ32). This mutation leads to a permanent lack of the protein and prevents penetration of virus by using this receptor. After transplantation, all of these 3 patients remained virus-free despite discontinuation of ART therapy. Conclusion. More research is needed to reduce the risk of using HSCT and perhaps in the future be able to use this therapy in all HIV-infected people.
Manifestations of post-traumatic stress in military personnel after participating in hostilities in the Russian-Ukrainian war
(Publishing Office of the University of Rzeszow, 2023-12) Prykhodko, Ihor; Matsehora, Yanina; Kryvokon, Nataliya; Hunbin, Konstantin; Kovalchuk, Oleksandr; Antusheva, Nataliia; Filonenko, Lesia
Introduction and aim. Since the beginning of the Russian-Ukrainian war, many Ukrainian military personnel began to show post-traumatic stress (PTS). The purpose of the article is to identify the features of PTS exhibited in different age groups in trauma-exposed military personnel during their participation in the psychological recovery program (“Invincibility Program”). Material and methods. Ukrainian Defense Forces military personnel (n=546 males, between 20 and 60 years of age) participated in this study. All participants were divided into three age groups. Determination of the features of PTS in military personnel was carried out using psychodiagnostic tests. Results. In each age group, more than half of the participants in the “Invincibility Program” had PTS characteristics such as the sub-threshold or clinical manifestations of PTSD, adjustment disorders, low resilience to combat mental trauma, and various sleep disorders combined with somatic complaints. The data showed higher features of PTS in the younger participants and they decreased in both the 2 older sets of participants. Conclusion. The age-related features of the manifestation of PTS in military personnel must be taken into account when developing psychological recovery programs: for younger participants, such events should be carried out longer and more intensively.
Nursing students’ awareness of health-promoting lifestyle profile and sustainable development goals – a quasi-experimental study
(Publishing Office of the University of Rzeszow, 2023-12) Dolu, lknur; Bozkurt, Feyza Demir
Introduction and aim. Health promotion is one of the common elements of sustainable development goals. The aim of this study was to identify the impact of “Healthy Life and Environment” course on nursing student’s awareness of sustainable development and healthy life, and health-promoting lifestyle behaviours. Material and methods. A pre-, and post-test control group quasi-experimental research design was used. One nursing department located in Nortwest Blacksea region, Turkey. A total of 160 nursing students pursuing bachelor nursing programs. Students from first and second years who enrolled in the “Healthy Life and Environment” course assigned to intervention group, those who did not attend the course assigned to control group. Results. Female students had higher level of HPLP II and SDA than male. SDA had a weak correlation with HLA and a very week correlation with HPLP II at baseline. Intervention group had an improvement of .03 points in HPLP II, no change in HLA, and a slight improvement of .01 points in SDA, however these differences were not statistically important. Conclusion. The results of our study highlighted that nursing curricula need to be modified to incorporate sustainable development methodology using student-centered learning.
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
(Publishing Office of the University of Rzeszow, 2023-12) Omon, Emmanuel Akokhamen; Ajayi, Olawale David
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Percutaneous sclerotherapy using polidocanol in the treatment of aneurysmal bone cysts of extremities – a report of 28 consecutive cases
(Publishing Office of the University of Rzeszow, 2023-12) Harshwal, Raj Kumar; Kumawat, Email src Kaushal Kishore; Saini, Narender; Sehrawat, Manisha; Meena, Devi Sahay
Introduction and aim. Aneurysmal bone cysts (ABC) are aggressive benign lesions with high rates of recurrence rendering its treatment uniquely challenging. We report the outcome in 28 consecutive patients of ABC of extremities treated with percutaneus sclerotherapy using 3% polidocanol over a period of 5 years. Material and methods. In biopsy proven 28 ABC cases, Injection polidocanol 3% was used as sclerosing agent under fluoroscopy guidance. Injections were repeated at 6-week intervals till complete healing of cysts. Radiological and functional results were assessed by Rastogi et al. criteria, VAS score and Enneking scoring method. Results. 25 out of 26 patients (89.28%) displayed good clinical response with an average 2.56 injections per patients. The mean follow-up period was 17.04±7.08 months. Reduction in cyst volume (mean 6.86±1.48 to 0.71±1.48.) and VAS score (mean 6.72±1.51 to 0.56±1.08) and improvement in Enneking score (17.35±3.14 to 28.92±1.35) at last follow up was significant. No recurrence was reported during the study period. Treatment failure, skin sclerosis and infection were reported in one case each. Conclusion. sclerotherapy with polidocanol 3% for primary ABC is safe and effective alternate method with advantage of no surgical morbidity, having better functional score with lesser recurrence and minimal complications.
Plasma level of beta endorphin in seborrheic dermatitis patients
(Publishing Office of the University of Rzeszow, 2023-12) Vysochanska, Vlasta; Koval, Galina
Introduction and aim. Defects in the epidermal barrier, changes in sebum secretion and its composition, Malassezia spp. overgrowth, endocrine, immune, and neurological disorders are the main pathogenesis items of seborrheic dermatitis (SD). “The opioid system of the skin” was considered a new target in the diagnosis and treatment of SD. The study aimed to determine beta-endorphin (BE) levels in adult patients with seborrheic dermatitis and correlate them with the severity of symptoms and itching. Material and methods. 26 healthy and 62 SD people were examined. SEDASI scale were used to estimate the severity of symptoms and intensity of itching. The determination of the beta-endorphin level was carried out by the ELISA method with the test system Human BE NBP2 (78774 Novus Biologicals). Results. BE in the SD group was higher compared to the control group (35.5 pg/mL, 22. pg/mL, p<0.001). The level of BE in seborrheic patients did not depend on age and sex but was rising with severity of symptoms. Positive correlations were found between the level of BE and the SEDASI was 0.42 (p<.001), between the level of BE and itching was 0.332 (p=0.009). Conclusion. SD patients have an increased level of BE that positively correlates with itching and disease severity.
Predictors of adverse perinatal outcomes in women at 40 weeks or more of pregnancy
(Publishing Office of the University of Rzeszow, 2023-12) Sert, Zekiye Soykan; Dilmaç, Ayşegül Evren; Alkan, Ender; Sert, Ekrem Taha
Introduction and aim. To evaluate the clinical features of women at ≥40 weeks of pregnancy and the utility of obstetric Doppler indices in predicting adverse perinatal outcomes in these pregnancies. Material and methods. This prospective study was conducted at a single academic medical center between 2020 and 2022. Women aged 18 years and older with no risk factors who were at ≥40 weeks of pregnancy and delivered their babies in our hospital were included in the study. The fetal biometry, placental maturity grading, and doppler velocytometry indices of the pregnant women were evaluated. The cases were divided into two groups according to the development of adverse perinatal outcomes. The relationship between clinical features and adverse perinatal outcomes was evaluated. Results. Adverse perinatal outcomes developed in 19.6% (42) of the 214 cases. The multiple logistic regression analysis was performed to identify factors affecting perinatal outcomes. Accordingly, a maternal age of ≥35 years (odds ratio [OR]: 1.74, 95% confidence interval [CI]: 1.29–3.96, p=0.038), nulliparity (OR: 1.42, 95% CI: 1.13–4.63, p=0.040), and grade 3 placental calcification (OR: 1.98, 95% CI: 1.11–4.53, p=0.029) were independent predictors of adverse perinatal outcomes. Conclusion. Care should be taken in terms of adverse perinatal outcomes in the presence of nulliparity, a maternal age of ≥35 years, and grade 3 placental calcification in ≥40 week pregnancies.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023) według Tytuł