European Journal of Clinical and Experimental Medicine T.21, z. 1 (2023)
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- PozycjaApplication of kinesitherapy within the process of rehabilitation of patients with Charcot-Marie-Tooth nerval amyotrophia(Publishing Office of the University of Rzeszow, 2023-03) Rybalko, Lina; Kletsenko, Liudmyla; Vyshar, Yevheniia; Heta, Alla; Żukow, Xawery; Levkov, Anatolij; Zukow, Walery; Muszkieta, Radosław; Hagner-Derengowska, Magdalena; Smoleńska, Olga; Kindrat, VadimIntroduction and aim. Researching inherited polyneuropathy is vastly topical in the course of the contemporary practice of physical therapy and ergotherapy. The article unveils the results of the application of kinesitherapy in the process of rehabilitation of patients with Charcot-Marie-Tooth nerval amyotrophia. Inherited Charcot-Marie-Tooth neuropathy is a genetical disease, which is manifested with the slow reduction of the size of muscles of limbs and weakening of distal locations, is the most widespread clinical form of inherited polyneuropathies, which affect people regardless of generational and gender-based; mostly young and workable people become the objects suffering from its impact. Description of the case. Due to the relatively low frequency of the multiplication of the disease within the population (according to the data from clinical statistics, the prevalence of all types of Charcot-Marie-Tooth amyotrophia per 100 thousand people is approximately 36 cases) four patients with Charcot-Marie-Tooth nerval amyotrophia aged in the area from 14 to 20 years took part in the research. In the course of the research, we applied the method of electroneuromyography, which provided the opportunity of detecting the rate of impulse impact via afferent and efferent ways, the duration of M-response and the number of movable entities within lower limbs. Conclusion. As a result of classes being held and carried out according to the experimental kinesitherapy study program, there was the detection of positive tendencies of changing the psychophysical state of patients, diagnosed with “Charcot--Marie-Tooth nerval amyotrophia”.
- PozycjaPostpartum takotsubo cardiomyopathy complicated with severe pulmonary edema and cardiogenic shock – a case report(Publishing Office of the University of Rzeszow, 2023-03) Bembey, Raghavi Abhilesh; Jha, Rajesh RanjanIntroduction and aim. Takotsubo cardiomyopathy (TCM) is a rare but life-threatening illness that can affect middle aged, young and pregnant women. It is a cardiac emergency and can mimic many other life threatening conditions like myocardial infarction, acute myocarditis, peripartum cardiomyopathy or dilated cardiomyopathy and is diagnosed by exclusion. Description of the case. Here we report a rare case of takotsubo cardiomyopathy in a young 28 year old female immediately post vaginal delivery of her normal full term twin pregnancy, who was otherwise a healthy female. She went on to develop complication of left ventricular heart failure and cardiogenic shock, which were successfully managed by conservative treatment leading to a full recovery. Conclusion. Takotsubo or stress cardiomyopathy is a rare entity and often a missed diagnosis, which if caught on time and treated leads to great prognosis. Our patient made a full recovery and is living a healthy life.
- PozycjaCase of multisystem inflammatory syndrome in adults(Publishing Office of the University of Rzeszow, 2023-03) Dominik, Hanna; Dominik, BarbaraIntroduction and aim. Multisystem inflammatory syndrome in adults (MIS-A) is a rare severe illness which is related to prior SARS-CoV2 infection in individuals>=21 years old. The condition was described few months after recognition of similar entity in children known as MIS-C (United Kingdom, April, 2020). The diagnosis of MIS-A is based on clinical symptoms andevidence of inflammation in laboratory markers. It is characterized by extrapulmonary organ dysfunction (cardiovascular, gastrointestinal), general symptoms such as fever, malaise, rash and deviations in blood tests (elevated level of ferritin, procalcitonin, CRP, IL-6, D-Dimer) with a previous or current SARS-CoV-2 infection. The purpose of this study is to present the syndrome on the basis of a clinical case example, to show the course of the disease, its symptoms and the result of applied treatment. Description of the case. The following case describes the clinical history, diagnostic process and applied treatment of 37-year old female patient who was admitted urgently to the hospital with a suspicion of sepsis originating from pharynx. The final diagnosis – MIS-A was settled after performing a broad panel of tests. Clinical picture was non- characteristic. The patient was successfully treated with steroids. Conclusion. MIS-A is a rare clinical entity linked with SARS-CoV-2 infection. The symptoms manifest from multiple organ systems and the diagnostic process may be challenging. The illness can be successfully treated with steroids.
- PozycjaTaking medicine in the right way – most important but most neglected(Publishing Office of the University of Rzeszow, 2023-03) Mohiuddin, Abdul KaderIntroduction and aim. To cure any disease, proper use of medicine or taking medicine in the correct order is required. Even patients from developed countries struggle to maintain their drug compliance. There is an odd parallel between underdeveloped, emerging nations and the so-called developed world in the West when it comes to improper medicine use. The understanding and perception of the disease is the most important factor influencing whether patients stick to their treatment plan. Material and methods. Prioritized databases for public health topics included PubMed, ALTAVISTA, Embase, Scopus, Web of Science, and the Cochrane Central Registers. Along with other online sources, journals from Elsevier, Springer, Willey Online Library, and Wolters Kluwer were thoroughly searched. Analysis of the literature. There is a thorough discussion of medication non-adherence issues and a few adherence-improving methods. Conclusion. Adherence to treatment guidelines is essential in the treatment of any disease.
- PozycjaEndophytes – untapped resources and pharmacological prospects against coronaviruses(Publishing Office of the University of Rzeszow, 2023-03) Earnest, Oghenesuvwe Erhirhie; Ezeagha, Chigozie Celestina; Okafor, Glory Chiamaka; Ikegbune, Chidozie; Mukim, MohammadIntroduction and aim. Viral infections stand to be among the most devastating diseases globally. Though significant efforts have been made in research and drug development against viral infections, the search for safe, affordable and effective vaccines against the current ravaging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still on. This is because already approved vaccines still need improvement. This review draws the attention of researchers on the potentials of bioactive substances from endophytes against the novel coronaviruses. Material and methods. This assessment was made using references of articles published in English peer reviewed journals indexed in PubMed and Google Scholars databases up to June, 2022. The following key words were used; ‘coronaviruses’, ‘Endophytes’, ‘Endophytes and viral infections, ‘Endophytes and COVID-19, ‘SARS-CoV’. Analysis of the literature. In-silico, in-vitro and in-vivo studies revealed that natural compounds from endophytes showed antiviral activities against various human coronavirus, including HCoV 229E and a norovirus surrogate, the feline coronavirus FCV F9, COVID-19, Coronavirus 2 (SARS-CoV-2), SARSCoV-2 Mpro, among others. Conclusion. This finding calls for researchers to also focus on endophytes, as part of drugs development in the bid to finding possible solution in combating the devastating COVID-19, an emerging situation.