European Journal of Clinical and Experimental Medicine T.23, z. 2 (2025)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/11570

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Przeglądanie European Journal of Clinical and Experimental Medicine T.23, z. 2 (2025) według Temat "anti-Müllerian hormone"

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  • Obrazek miniatury
    Pozycja
    Endogenous and exogenous factors influencing anti-Müllerian hormone levels in women of reproductive age
    (Rzeszów University Press, 2025-06) Jankowska, Olga; Kraśnik, Wojciech; Kurzeja, Jacek; Piotrowicz, Katarzyna; Piotrowicz, Hubert; Bajkacz, Agnieszka; Rogala, Anna; Osmólska, Joanna
    Introduction and aim. Anti-Müllerian hormone (AMH) is a key marker of ovarian reserve (OR), which declines with advancing reproductive age. Certain pathological conditions can reduce OR or lower AMH levels independently of age, potentially impairing fertility. This study aims to review the scientific literature on factors influencing AMH levels and the causes of diminished OR, including lifestyle, diet, supplementation, pathogenic factors, environmental influences, and genetic predispositions. Material and methods. This review was conducted using electronic databases, including PubMed and Google Scholar. A comprehensive search was carried out across these databases, covering the period from 2007 to 2024. The inclusion criteria encompass studies on AMH and factors influencing ovarian reserve, that present either quantitative or qualitative data. Analysis of the literature. The most important factor determining the level of AMH is age. In addition, factors that may influence hormone levels include genetic background, autoimmune diseases, polycystic ovary syndrome (PCOS), environmental toxins, diet, supplementation, oral contraception, physical activity, and smoking. Conclusion. The causes of reduced OR and abnormal AMH levels remain unclear in many cases. Recommendations for the prevention of pathologically reduced OR include lifestyle modifications, a diet rich in antioxidants, avoiding toxins, refraining from smoking, appropriate supplementation, genetic testing, and regular blood tests.
  • Obrazek miniatury
    Pozycja
    Evaluation of hormonal and adipokine biomarkers in the diagnosis of polycystic ovary syndrome – a case-control study
    (Rzeszów University Press, 2025-06) Alredha, Redha Dawud Abd; Haddawi, Krarr Haider; Al-Hayali, Wisal Raoof; Yaseen, Bushra Raouf
    Introduction and aim. Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly affects women of reproductive ages. This study evaluated the diagnostic potential of hormonal biomarkers such as anti-Müllerian hormone (AMH), total and free testosterone, ratio of luteinizing hormone (LH/FSH) ratio, and adipokines, including visfatin and kisspeptin, in distinguishing PCOS patients from healthy controls. Material and methods. In this case-control study, 50 women diagnosed with PCOS were compared with 50 controls of the same age. Demographic and clinical data were collected through structured interviews and physical examinations. Physical activity levels was assessed using the International Physical Activity Questionnaire short form as well as anthropometric measurements were performed using a calibrated digital scale Seca 803. Blood samples were analyzed for AMH, total and free testosterone, LH/FSH ratio, visfatin, and kisspeptin levels using enzyme-linked immunosorbent assay. Results. PCOS patients exhibited significantly higher levels of AMH (8.1±2.3 ng/mL vs. 4.07±1.1 ng/mL, p<0.001), Free testosterone (4.55±0.95 pg/mL vs. 2.47±0.46 pg/mL, p<0.001), visfatin (86.6±11.02 ng/mL vs. 49.53±10.25 ng/mL, p<0.001), and kisspeptin (9.88±1.96 ng/mL vs. 4.84±1.07 ng/mL, p<0.001) compared to controls. Logistic regression showed that elevated levels of AMH (odds ratio [OR]=2.95, p=0.0056), visfatin (OR=1.7, p=0.0043) and kisspeptin (OR=18.3, p=0.0015) were strongly associated with PCOS. Conclusion. These findings confirmed the significant role of AMH, testosterone, visfatin, and kisspeptin in the diagnosis of PCOS. Integration of adipokine markers, particularly visfatin and kisspeptin, with traditional hormonal markers enhances diagnostic accuracy.