Salivary microbial diversity – an investigation on possible biomarkers for polycystic ovarian syndrome from eastern India

Ładowanie...
Obrazek miniatury

Data

2023-12

Tytuł czasopisma

ISSN

Tytuł tomu

Wydawnictwo

Publishing Office of the University of Rzeszow

Abstrakt

Introduction and aim. Polycystic ovarian syndrome (PCOS) is one of the major reproductive health issues, thought to be multifactorial, needs serious attention as a dual burden (health and economic) mainly for developing countries like India, due to its rapid rise (30%) in the last couple of years. Therefore, widespread and liberal screening for this disorder towards prognosis, diagnosis and intervention seems to be an urgent area of research. In this background, the present study attempts to unravel the association of salivary microbial diversity and PCOS. Material and methods. To achieve the purpose 100 clinically diagnosed PCOS individuals and 110 age matched non-PCOS participants from Bengalee Hindu caste population, West Bengal, India was considered. Obtained salivary samples were identified with 16S rDNA amplification and microbial diversity were determined by Alu I restriction enzyme digestion. Results. The present study revealed an explicit pattern of DNA fragment lengths varied between 200 bp and 225 bp in PCOs in comparison to the non-PCOS group. Conclusion. The cardinal feature of the present study as the first attempt from India envisaged, utilization of salivary microbial diversity as an additional potential and economizing biomarker for PCOS that stimulate new horizon of research in 21st century’s anthropology – the anthropology of microbes.

Opis

Institutional Ethical Committee for Bio Medical and Health Research involving Human Participants, University of Calcutta & Secretary, UCSTA, C.U., Ref no.: CUIEC/02/15/2022-23.

Cytowanie

European Journal of Clinical and Experimental Medicine T. 21, z. 4 (2023), s. 736–741