Association between hearing organ and renal function in young adult type 1 diabetic patients. A cross-sectional study.

Skrócona strona pozycji
dc.contributor.authorDąbrowski, Mariusz
dc.contributor.authorMielnik-Niedzielska, Grażyna
dc.contributor.authorNowakowski, Andrzej
dc.date.accessioned2018-05-03T15:12:58Z
dc.date.available2018-05-03T15:12:58Z
dc.date.issued2018
dc.description.abstractBackground: Type 1 diabetes can lead to impaired function of many organs and tissues. The aim of this study was to evaluate associations between hearing and kidney function in young adult type 1 diabetic patients. Methods: 31 patients (9 women) with type 1 diabetes, aged <45, with disease duration <10 years were included. Blood and urine samples for laboratory tests and urinary albumin excretion (UAE) assessment were obtained. eGFR was calculated with CKD-EPI formula. In all patients pure-tone audiometry, transient evoked otoacoustic emissions and auditory brainstem responses were evaluated, also eye fundus was examined. Results: Mean patients’ age was 29.5±7.0 years and disease duration 4.6±2.6 years. All patients had eGFR >60.0 ml/min/1.73 m2. In one case microalbuminuria and in 3 patients early retinopathy were revealed. Linear correlation between eGFR and hearing threshold at 4, 6, 8 and 12 kHz was found. Patients with hearing impairment (n=7) had lower eGFR 108.8 vs. 121.7 ml/min/1.73 m2, p=0.047 compared to normal-hearing subjects. Also patients with absence of otoacoustic emissions in at least one ear had lower eGFR, 103.1 vs. 123.3 ml/min/1.73 m2, p<0.001, compared to the remaining group. In auditory brainstem responses we found significant linear correlation between eGFR and wave III and interval I-III latencies, and between UAE and waves III, V and interval I-III latencies. Conclusions: This study indicate possible relationship between hearing and kidney function in type 1 diabetic patients. Pathways directly linking hearing and renal function are unknown. Larger studies are necessary to further analyze these relationships.pl_PL.UTF-8
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/3521
dc.language.isoengpl_PL.UTF-8
dc.subjectType 1 diabetespl_PL.UTF-8
dc.subjectHearing impairmentpl_PL.UTF-8
dc.subjectPure-tone audiometrypl_PL.UTF-8
dc.subjectOtoacoustic emissionspl_PL.UTF-8
dc.subjectAuditory brainstem responsespl_PL.UTF-8
dc.subjectGlomerular filtration ratepl_PL.UTF-8
dc.subjectAlbuminuriapl_PL.UTF-8
dc.titleAssociation between hearing organ and renal function in young adult type 1 diabetic patients. A cross-sectional study.pl_PL.UTF-8
dc.typeworkingPaperpl_PL.UTF-8
Pliki
Oryginalny pakiet
Aktualnie wyświetlane 1 - 1 z 1
Obrazek miniatury
Nazwa:
Hearing and kidney.xlsx
Rozmiar:
23.13 KB
Format:
Microsoft Excel XML
Opis:
Hearing organ and kidney function - Raw data
Pobierz
Pakiet licencji
Aktualnie wyświetlane 1 - 1 z 1
Obrazek miniatury
Nazwa:
license.txt
Rozmiar:
1.22 KB
Format:
Item-specific license agreed upon to submission
Opis:
Pobierz
Kolekcje
Sprawozdania, raporty (KNM) / Reports (CoMS)