Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome

Obrazek miniatury
Rahamon, Sheu Kadiri
Ganiyu, Arinola
Charles-Davies, Mabel Ayebatonyo
Akinlade, Kehinde Sola
Olaniyi, John Ayodele
Fasanmade, Adesoji Adedipe
Oyewole, Oyediran Emmanuel
Owolabi, Mayowa Ojo
Adebusuyi, Jane Roli
Hassan, Olufunke Olayemi
Tytuł czasopisma
Tytuł tomu
Wydawnictwo Uniwersytetu Rzeszowskiego
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
Results from this study were presented at the 11th Congress of the Federation of African Immunological Societies (FAIS).
Słowa kluczowe
inflammation , metabolic syndrome , vitamin D
European Journal of Clinical and Experimental Medicine T. 19, z. 4 (2021), s. 306–312