European Journal of Clinical and Experimental Medicine T.20, z. 1 (2022)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/7592

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A benign entity – cerebral multinodular and vacuolating neuronal tumor
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Kış, Naciye; Erok, Berrin; Kılıç, Harun; Önder, Hakan
Introduction and aim. Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare benign, mixed glial/ neuronal lesion which has been included in the recent (2016) World Health Organization (WHO) Classification of the central nervous system tumors.Most of the reported cases are remarkable with adult onset seizure in the literature.They can also be found incidentally in nonepilepsy patients with or without headache We aimed to present this unique entity with its typical magnetic resonance imaging (MRI) features. Description of the case. A 21-year old man presented with complaint of headache that increased in frequency within the last few months.No relevant seizure or any other signs of note.He was diagnosed with MVNT by imaging andstarted to be followed- up.The repeat MRI 6 months later showed no interval changes. Conclusion. Clinicians should be aware of that it is a do not touch lesion in asymptomatic patients with no need for biopsy or surgery and follow up imaging is sufficient when presented with the typical MRI manifestations. Surgical resection may be required for seizure control and was reported in few cases with no tumoral regrowth in the literature.
Non-ketotic hyperglycemia and diabetic striatopathy – a rare presentation with hemichorea-hemiballismus
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Erok, Berrin; Keklikoğlu, Taha Oğuz; Kış, Naciye; Önder, Hakan
Introduction and aim. Non-ketotic hyperglycemia (NKHG), also known as hyperosmolar hyperglycemic state (HHS) is a serious metabolic complication of diabetes mellitus (DM).The mortality rate can be up to 20% and this is much more higher than that of diabetic ketoacidosis (DKA). It is usually precipitated by an event such as pulmonary/urinary infection, myocardial infarction (MI) or stroke. In this state of metabolic derangements, central nervous system (CNS) manifestations including altered mental status with or without focal neurological deficits are prominent clinical presentations. On the other hand, HHS may also be complicated with various other CNS events. Herein, a quite rare presentation of HHS with hemichorea ‒ hemiballismus in a 71 year old female patient with type 2 DM is presented. Description of the case. A 71-year-old female patient type 2 DM presented to our emergency department with progressive involuntary movements on the right upper and lower extremities accompanied by semiconsciousness during the last 24 hours. On neurological examination, cranial nerves and cerebellar signs were found to be normal, as the deep tendon reflexes. However, involuntary non-rhythmic writhing movements at rest were present on her right sided extremities. The fingerstick evaluation showed marked hyperglycemia (HG). The laboratory findings were characterized with high blood glucose level without obvious acidosis compatible with HHS. In urine analysis, glucosuria without significant ketonuria was detected. On head CT, subtle hyperdensity was noted in the left neostriatal regions without any mass effect or perilesional edema, compatible with left sided diabetic striatopathy (DS). Conclusion. Diabetic striatopathy is a quite rare presentation of HHS with hemichorea – hemiballismus. The characteristic computed tomograhy (CT) findings of associated striatopathy should be differentiated from vascular lesions that may also present with unilateral findings in the course of HHS and should not be overlooked in diabetic patients to recognise the ongoing HHS before the coma precedes.
Paired box 8 in organogenesis and oncogenesis – a review
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Szpunar, Magdalena
Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein product gene that plays an essential role in organogenesis and oncogenesis. The aim of this paper was to discuss structure and function of PAX-8. The aim of this study is to determine the utility of PAX-8 in cytology effusions with metastatic tumor. Material and methods. This article is a review done in regards to discuss the role knowledge on PAX-8 especially in oncogenesis and organogenesis. Analysis of the literature. Current information about PAX-8 is presented. Conclusion. The PAX family of genes plays an important role in the formation of tissues and organs during embryonic development and in maintaining the proper functioning of certain cells after birth.
Current research opportunities for potential phytotherapeutic agents for the treatment of pathologies of the female reproductive system
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Sokolik, Olena Petrivna; Prozorova, Galina Olexandrivna
Introduction and aim. Herbal medicine is prescribed for various disorders of the menstrual cycle (uterine bleeding, dysmenorrhea), for the treatment of premenstrual and climacteric syndromes, inflammatory diseases of the genital organs, mastopathy and mastalgia and other pathological conditions. The aim of the study is to analysis and generalization of data from professional literature and own experience in the treatment of patients with pathologies of the female reproductive system by phytotherapeutic methods, taking into account the influence of medicinal plants on various links in the pathogenesis of the disease, as well as making recommendations for improvement and prospects for the use of phytotherapy in the treatment of this pathology. Material and methods. To make an analysis of literary sources of domestic and foreign authors about usage of medicinal plants for the treatment of pathologies of the female reproductive system. Analysis of the literature. In the treatment of primary (spasmodic) dysmenorrhea, herbal remedies with an antispasmodic, analgesic, hormone-mimetic effects are prescribed. It can be Chamomile (Matricaria chamomilla L.), Achillea millefolium, commonly known as yarrow, Viburnum, Shepherd’s purse (Capsella bursa-pastoris), Greater celandine, Atropa belladonna, Hyoscyamus niger, commonly known as henbane, black henbane, or stinking nightshade and Abraham’s tree. Many plants have bactericidal activity, and this property is used in the treatment of inflammatory diseases of the mucous membranes and skin. Such properties are possessed by flowers of Chamomile (Matricaria chamomilla L.), Calendula officinalis, infusion of Medicinal sage (Salvia officinalis L.). For the treatment of functional hyperprolactinemia phytopreparations are also successfully used. It is known that the medicinal plant Vitex agnus castus has dopaminergic properties, selectively blocking prolactin synthesis, and reduces follicle stimulating hormone levels. Strychnos ignatia, Caulophyllum thalictroides, European cyclamen, Lilium tigrinum, Iris versicolor provide a complex effect on the female body, effectively reduces the level of prolactin and the severity of mastalgia, which is confirmed not only by clinical data, but also by mammography data in fibrocystic breast disease. For the treatment of climacteric syndrome, a large number of medicinal plants are used, in particular, the most popular is the Cimicifuga racemose. Conclusion. The effectiveness of phytotherapeutic drugs has been verified by many clinical trials. Modern phytotherapy is becoming more widespread in clinical practice, as an alternative to drug treatment.
Nanomedicine – a review
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Dynarowicz, Klaudia; Aebisher, David
Introduction and aim. Nanomedicine is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. This department deals with everything on the nano scale, i.e. on the level of individual atoms and molecules. This work presents the nano scale, i.e. on the level of individual atoms and molecules. Nanotechnology is currently one of the most popular and dynamically developing fields, not only in electronics, but above all in pharmacy and medicine. Material and methods. In this article a narrative review regarding nanomedicine. Analysis of the literature. The desire to summarize information about nanomedicine application of singlet oxygen is presented. Nanotechnology is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. Conclusion. The use of nanostructures is currently very efficient. The areas in which the potential of nanoparticles is constantly researched and confirmed by numerous articles are: radio- and chemotherapy, cancer diagnostics and imaging medicine (MRI and fluorescence imaging).
Breast hypertrophy, forward head posture, neck and shoulder pain-related disabilities and selected anthropometrics variables of female undergraduate students
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Akodu, Ashiyat Kehinde; Oti, Temiloluwa Grace; Lawal, Abdulrazzaq Oluwagbemiga
Introduction and aim. Large breast sizes frequently contribute to women presenting with severe pain symptoms. This study determined the association between breast hypertrophy, forward head posture (FHP), neck and shoulder pain related disabilities and selected anthropometric variables of female undergraduate students of College of Medicine, University of Lagos. Material and methods. A cross-sectional analytical study was conducted among 89 female undergraduate students (mean age = 21.45±1.29 years) with breast hypertrophy (cup size D and above). Breast cup sizes, neck and shoulder pain related disabilities, forward head posture were measured using a measuring tape, neck pain disability scale, shoulder pain disability index and craniovertebral angle (CVA) using photography method. Results. The prevalence of forward head posture among the participants was 43(48.3%). Twenty-eight (31.3%) participants had a “DD” cup size, twenty-six (29.2%) participants had a “DDD” cup size. Sixty-five (73%) of the participants had neck pain related disabilities and 10 (11.2%) of the participants had shoulder pain related disabilities. There was association among weight, forward head posture (p=0.027) and breast hypertrophy (p=0.016). Conclusion. Neck, shoulder pain related disabilities, and forward head posture is prevalent among undergraduates with breast hypertrophy and weight has an influence on forward posture and breast hypertrophy.
Contribution of bread and biscuits to vitamin A daily requirement of preschool children in Lagos State, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Uchendu, Florence N.; Oyewole, Oyediran Emmanuel
Introduction and aim. Vitamin-A-deficiency is a public health problem among preschool children of Nigeria. Study determined the contribution of bread and biscuits to vitamin A-daily-requirement of preschool children in Lagos-State, Nigeria. Material and methods. A community-based-study using a cross-sectional-design with analytical component was carried out from 2013-2015. Multi-stage-sampling-technique was used to select mothers of preschool-children (n=1599) in 5 Local-Government- Areas of Lagos. Respondents’ socio-demographic information and samples consumption-pattern were collected using validated, food-frequency-questionnaire/dietary recall. Retinyl palmitate content of randomly selected commonly-consumed brands of oven-fresh-bread stored for 5-days and biscuits (30- to 60-days) at prevailing outdoor-market-temperatures were analysed using High-Performance-Liquid-Chromatography. Contribution to preschool children’s vitamin A-daily-requirements were determined. Data were analysed using Student’s t-test and ANOVA at p<0.05. Results. Mean age of preschool children was 31.44±5.28 months. Mean intakes of samples were bread (117.6 ±15.9 g/d) and biscuits (59.8±27.9 g/d). Range of contribution to vitamin-A-daily-requirement of preschool-children was 0-178.4 %. Samples contribution to vitamin A-daily-requirement of pre-school-children were oven-fresh bread (68.3 %); 5 days bread (20.7%); 30-days biscuits (25.0%) and 60-days biscuits (6.8%). Overall contribution to vitamin A-daily-requirement were bread (51.4%) and biscuits (22.4%). Statistically significant difference existed between samples contribution and vitamin-A-daily-requirement of preschool children. Conclusion. Bread and biscuits samples contributed significantly to the vitamin-A-daily-requirement of preschool children.
Assessment of the effect of size of the umbilical ring on the risk of umbilical hernia complication in children
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Emeka, Chukwubuike Kevin; Chikaodili, Eze Thaddeus
Introduction and aim. Assessment of risk of complications in umbilical hernia is important. The aim of this study was to evaluate the effect of size of the umbilical ring on the risk of complication occurring in umbilical hernia. Material and methods. This was a prospective study of children who had umbilical hernia repair for symptomatic umbilical hernia. Using Vernier caliper, the umbilical ring diameter (URD) was measured at surgery and the patients were divided into 2 groups. Group A had URD of less than of 15 millimeter (mm) and group B patients had URD of 15 mm and above. The 2 groups were compared. Results. Thirty two cases were evaluated. Their mean age was 42 months. All the patients had umbilical pain. Twenty six (81.3%) patients had URD of less than 15 mm (group A) whereas 6 (18.7%) patients had URD of greater or equal to 15 mm (group B). Group A patients had a mean URD of 12.1±3.4 mm whereas group B patients had a mean URD of 30.5±5.0 mm (p=0.001). Conclusion. Children who have URD of less than 15 mm are at a higher risk of developing umbilical hernia complications.
Oxidative and nitrosative stress in patients with meningitis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Namiduru, Emine Siber; Namiduru, Mustafa; Karaoğlan, İlkay; Koçak, Kübra
Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TAS) and total antioxidant status (TOS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.
Muscle energy technique and static stretching in patients with mechanical neck pain – a randomized study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Ojoawo, Adesola O.; Ige, Blessing; Kunnuji, Kanode
Introduction and aim. Neck pain is becoming increasingly common throughout the world with a considerable impact on individuals. This study compared the effects of muscle energy techniques (MET) and static stretching (SS) on pain intensity and functional disability of patient with mechanical neck pain. Material and methods. Fifty subjects with mechanical neck pain recruited were randomly allocated into MET and SS groups equally. Subjects in MET received MET protocol, and SS groups were treated with SS; both groups had treatment twice a week for six weeks. Pain intensity and functional disability at baseline, 3rd and 6th week of treatment were measured. Descriptive and Inferential statistics were used to analyze the data. Alpha level was set at <0.05. Results. There were 12 males and 13 females for MET with age ranged between 31–53 years mean was 42.41± 7.35 years and 11 males and 14 females in SS group with age range 22–60 years and mean age of 42.91±10.44 years. There was a significant reduction in pain intensity and disability in MET’s and SS group (p<0.05) when pre-treatment, 3rd week and 6th week treatment were compared. Pain intensity was lower at SS than MET while functional disability was lower in MET than SS p<0.05 at 6th week Conclusion. MET reduces ND more than SS and SS reduces pain intensity better MET.
Topical lidocaine anesthesia for nasopharyngeal sampling – a double-blind randomized placebo-controlled trial
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Tekyol, Davut; Akbas, Ilker; Dogruyol, Sinem; Kocak, Abdullah Osman; Çakır, Zeynep
Introduction and aim. The aim of this study is to evaluate the effects of topical lidocaine application for nasopharyngeal sampling, on pain perception, the comfort of the patients, and the application difficulty for healthcare staff. Material and methods. This study conducted with 100 healthy volunteers (50 participants in Lidocaine group and 50 participants in Placebo group). Two ml of a solution containing 10 mg/ml of lidocaine was applied to each nostril of the participants in the Lidocaine group, and the same dose of 0.9% NaCl to the Placebo group. We compared the changes in pain intensity and discomfort intensity using two numerical rating scales, the frequency of undesirable reactions, and the judgment of the practitioner staff. Results. There were statistically significant decreases in pain and discomfort scores in the Lidocaine group. Similarly, there were statistically significant decreases in the frequency of all undesirable reactions except “grimace”, in the second sampling in the Lidocaine group, however, there was a statistically significant decrease only in “holding staff’s hand” in second sampling in the Placebo group. Conclusion. Intranasal lidocaine application reduces the pain that occurs during nasopharyngeal sampling and makes the procedure easier for the patient and the healthcare worker.
The incidence and pattern of non-odontogenic orofacial pain conditions at a tertiary hospital in Tanzania
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Hirani, Vanisha Aroon; Owibingire, Sira Stanslaus; Moshy, Jeremiah Robert; Sohal, Karpal Singh
Introduction and aim. Non-odontogenic orofacial pain (NOFP) is a result of pathology, or injury to the structures in the orofacial region including the muscles, temporomandibular joint, neurovascular structures, and glands. This multi-diverse aetiopathogenesis poses a challenge in the diagnosis and management of NOPF. To determine the incidence and trend of various non-odontogenic orofacial pain conditions at a tertiary hospital in Tanzania. Material and methods. This cross-sectional study was conducted at the Muhimbili National Hospital (MNH) for 6 months. The information gathered included socio-demographic characteristics of participants, characteristics of pain, and cause of pain. Pain intensity was assessed using the Visual Analogue Scale (VAS). Results. The incidence of NOFP was 3.3%. The male to female ratio was 1.7:1 and the mean age of patients was 44.2 ± 17.4 years. The mean intensity of the pain using the VAS was 47.27 ± 5.66. Most (36.7%) patients experienced sharp pain. The common causes of NOFP were trauma (43.3%) and malignant lesions (38.3%). A statistically significant association between the age and sex of the patients and the causes of non-odontogenic pain was observed (p < 0.05). Conclusion. The incidence of non-odontogenic orofacial pain is low. Trauma and malignant conditions were the leading causes of NOFP.
Contribution of diffusion weighted MRI to the differential diagnosis of renal masses
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Kış, Naciye; Düzkalır, Hanife Gülden; Ağaçlı, Mehmet Oğuzhan; Erok, Berrin; Kılıçoğlu, Zeynep Gamze
Introduction and aim. We aimed to assess the usefulness of diffusion weighted imaging (DWI) and apparent diffusion coefficients (ADCs) for characterizing renal masses. Material and method. In this retrospective study we measured the ADC values of renal masses at b=0, b=500 and b=1000. Measurements were made by placing a circular region of interest with a diameter of 1 cm.ADC values from normal renal parenchyma were taken to define the ADC and to compare with the ADC values of the lesions. Results. A total of 72 lesions of 54 patients were included.40 of the masses were benign and 32 were malignant. The ADC values of benign lesions at both b values were significantly higher than malignant lesions. We found the lowest values in angiomyolipomas (AMLs) and oncocytomas and the highest values in Bosniac type I cysts. Similarities was found between the ADC values of some AMLs and the RCCs. In terms of statistical results, the inclusion of AMLs in the analysis did not significantly affect the difference between malignant and benign lesions. Conclusion. In our study, the ADC values of benign renal masses were higher than those of normal renal parenchyme, which is higher than those of malignant renal masses.The lowest ADC values were observed in AMLs and oncocytomas.
The knowledge and behaviors of mothers with children 0–3 aged about pacifier use – a cross-sectional study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Topan, Aysel; Kurt, Aylin; Yanik, Merve; Tatoğlu, Nilüfer; Özsavran, Musa
Introduction and aim. The use of pacifier is a very common practice in the early childhood period in the world. In recent years, the harms of pacifiers have been discussed rather than their benefits. We aimed to determine the knowledge and behaviors of mothers with children aged 0–3 about the use of pacifiers. Material and methods. A cross-sectional study was conducted with 363 mothers between January 10th and November 31st, 2020 in Zonguldak, Turkey. The data were collected with a web-based questionnaire. This article was prepared following STROBE guidelines. Results. The mothers started using the pacifier for the first time when their children were at an average of 2.86±3.31 months old, and they used it for at an average of 12.06±9.13 months. Of the mothers, 36.4% were found to clean the pacifier every month and 30.6% to have the behavior of dipping the pacifier into a product such as sugar, honey, molasses, and jam. The mothers with undergraduate degrees had the behavior of cleaning pacifiers more than those with postgraduate degrees (p<0.001). Conclusion. Mothers preferred to give pacifiers to babies at a high rate and had misinformation about the use of pacifiers that may harm their children’s health.
Arterial stiffness can predict cardiorespiratory fitness in type 2 diabetic patients?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Monteiro, Clara Italiano; Simões, Rodrigo Polaquini; Heubel, Alessandro Domingues; Silva, Claudio Donisete da; Ricci, Paula Angélica; Petronilho, Ariane; Borghi-Silva, Audrey; Mendes, Renata Gonçalves
Introduction and aim. Arterial stiffness (AS) has been associated with reduced cardiorespiratory fitness (CRF). The aim of this study was to verify if there is a relationship between augmentations index (AIx), as an index for AS assessment, and CRF in individuals with type 2 Diabetes Mellitus (T2DM). Material and methods. Observational cross-sectional study including 32 individuals diagnosed with T2DM who performed two evaluations: 1. Arterial stiffness assessment using SphygmoCor and 2. CRF throughout a cardiopulmonary exercise test on a treadmill ergometer. Oxycon Mobile® device was used to obtain oxygen uptake consumption at peak (V˙ O2peak); oxygen uptake efficiency slope (OUES) determined by linear regression in reason of the logarithmic transformation of the ventilation and V˙ O2 obtained every minute of exercise test. Statistical analysis comprised Pearson’s Correlation and linear regression analysis performed in SigmaPlot. Results. There was a significant correlation between AS and CRF: AIx and OUES; AIx@75 and; OUES. In linear regression, AIx was determinant for V˙ O2peak and OUES – AIx and; AIx@75 and V˙ O2peak. Conclusion. AS was associated with CRF in individuals with T2DM. These results contribute to the body of evidence linking arterial functional properties to CRF and suggests greater attention for this important index.
Healthcare services granted to patients with diagnosed acute initial or subsequent myocardial infarction in the Silesian voivodeship (Poland)
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Choręza, Piotr; Filipecki, Artur; Kowalska, Małgorzata; Owczarek, Aleksander J.
Introduction and aim. Cardiovascular diseases remains the leading cause of death in most of devoloped societies, including Poland. The study aimed to assess the changes in the number, duration, and costs of hospitalizations due to myocardial infarction in Silesian voivodeship (Poland) in 2009-2014. Material and methods. Data were obtained from the Silesian Voivodeship Branch of the National Health Fund. The number, costs, and duration of healthcare services granted during an inpatient hospital stay to patients with acute initial or subsequent myocardial infarction in 2009–2014 were processed and analyzed quarterly for the whole Silesian voivodeship and its subregions. Results. From 54826 patients aged 66±12, the majority were males (62.3%) and 63.4% of 80866 hospitalizations were granted to them. We observed a decreasing trend for the total number of healthcare services granted in 2009–2014 that varied depending on the subregion. Simultaneously, we found that in most subregions the costs of services and the number of invasive services increased over time. We observed that treating patients above 80 years with acute initial or subsequent myocardial infarction generated lower costs of hospitalization but was extended in time. Conclusion. Increased number and costs and accompanying reduced duration of hospitalizations granted in 2009–2014, especially in the range of invasive cardiology and cardiac surgery, results from implementing international guidelines and recommendations for acute myocardial infarction procedures. Lower cost and extended time of hospitalization for patients older than 80 years most likely result from using conservative (non-invasive) methods of treatment.
Clinical profile and management of patients with pediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2 – single-center experience
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Opalińska-Zielonka, Paulina; Wiącek, Katarzyna; Marczak, Paweł; Piasecka, Krystyna; Korczowski, Bartosz
Introduction and aim. Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) is a new condition that has emerged in children during the COVID-19 pandemic. Many clinical signs and symptoms resemble those found in Kawasaki disease (KD). Material and methods. The following data were considered: clinical presentation, comorbidities, laboratory findings, abnormalities in additional tests, exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the child and his family members, applied treatment and return to full health. Results. In the presented study nineteen children were analyzed. Fever was a universal finding in our group and it’s mean duration was 7 days (range 5-9). Other common symptoms included abdominal pain and severe weakness (in 89.5%), rash and conjunctivitis (in 84.2%), vomiting (in 73.7%) and mucous membrane involvement (in 63.2%). In nearly half of cases, echocardiography revealed fluid in the pericardial sac and left ventricular systolic dysfunction (in 52.6% and 47.4% respectively). 21.1% of patients had coronary artery abnormalities. 26,3% of the children required treatment with dopamine and/or milrinone. In 15.7% ICU admissions and assisted ventilation was necessary. No deaths were recorded. Conclusion. One should bear in mind that PIMS-TS can mimic KD, appendicitis and meningitis, which may pose a diagnostic challenge.
Neurological complications encountered in imaging studies in association with COVID-19 – a single center analysis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Erok, Berrin; Atca, Ali Önder; Önder, Hakan
Introduction and aim. COVID-19 is a viral infectious disease, which was first reported in patients with unusual pneumonia in December 2019. However, as the pandemic progressed, extrapulmonary manifestations including various neurologic complications have been started to be increasingly reported. In this retrospective study, we tried to search the neurological complications seen in our patients with positive rRT-PCR test for COVID-19 and examine the underlying associated risk factors. Material and methods. We have retrospectively analyzed the neuroimaging studies performed in our patients with positive rRT-PCR test for COVID-19 between April, 2020 and August, 2021. Both computed tomography (CT) scans and magnetic resonance imagings (MRI) of brain, head & neck region and the spine were retrospectively evaluated for the presence of any complications in patients with positive rRT-PCR test for COVID-19. Results. There were 147 patients having neuroradiological imaging studies performed for various neurological symptoms. Among these patients we detected 10 acute neurologicalcomplications.The most common was acute ischemic stroke in 5 patients and intracranial hemorrhage in 3 patients, two of which were intraventricular hemorrhage. The other complications included a preasumed cytotoxic lesion of corpus callosum in a 18 year old girl and lumbar spondylodiscitis complicated with psoas abcess in a 47 year-old man. Conclusion. In COVID-19 patients severe neurological complications can occur even as a presenting manifestation. Early cytotoxic endothelial injury can be the underlying cause in these patients and should be further studied in larger series in terms of what the susceptibility factors in these patients.

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