Sprawozdania, raporty (KNM) / Reports (CoMS)

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Association between hearing organ and renal function in young adult type 1 diabetic patients. A cross-sectional study.
(2018) Dąbrowski, Mariusz; Mielnik-Niedzielska, Grażyna; Nowakowski, Andrzej
Background: Type 1 diabetes can lead to impaired function of many organs and tissues. The aim of this study was to evaluate associations between hearing and kidney function in young adult type 1 diabetic patients. Methods: 31 patients (9 women) with type 1 diabetes, aged <45, with disease duration <10 years were included. Blood and urine samples for laboratory tests and urinary albumin excretion (UAE) assessment were obtained. eGFR was calculated with CKD-EPI formula. In all patients pure-tone audiometry, transient evoked otoacoustic emissions and auditory brainstem responses were evaluated, also eye fundus was examined. Results: Mean patients’ age was 29.5±7.0 years and disease duration 4.6±2.6 years. All patients had eGFR >60.0 ml/min/1.73 m2. In one case microalbuminuria and in 3 patients early retinopathy were revealed. Linear correlation between eGFR and hearing threshold at 4, 6, 8 and 12 kHz was found. Patients with hearing impairment (n=7) had lower eGFR 108.8 vs. 121.7 ml/min/1.73 m2, p=0.047 compared to normal-hearing subjects. Also patients with absence of otoacoustic emissions in at least one ear had lower eGFR, 103.1 vs. 123.3 ml/min/1.73 m2, p<0.001, compared to the remaining group. In auditory brainstem responses we found significant linear correlation between eGFR and wave III and interval I-III latencies, and between UAE and waves III, V and interval I-III latencies. Conclusions: This study indicate possible relationship between hearing and kidney function in type 1 diabetic patients. Pathways directly linking hearing and renal function are unknown. Larger studies are necessary to further analyze these relationships.
Beneficial effect of DASH diet combined with regular physical activity on fat mass, anthropometric and metabolic parameters in people with overweight and obesity. DATASET
(2023-08-06) Soroń, Małgorzata,; Więch, Paweł; Dąbrowski, Mariusz
Abstract Introduction. Obesity and overweight prevalence has reached pandemic level and became a growing health-related issue worldwide. Excess of fat mass is associated with increased risk of cardiovascular disease, diabetes, musculoskeletal disorders, neuropsychological disturbances, cancer and premature death. The aim of our study was to assess the effect of DASH diet combined with regular physical activity on fat mass, anthropometric and metabolic parameters in overweight and obese subjects. Methods. One hundred people (85 women) with overweight and obesity were included in the study. Mean age of study participants was 48.8±12.1 years and half of them had hypertension. In all study participants anthropometric measurements and laboratory tests were assessed and anthropometric as well as metabolic indices were calculated at baseline and after three months of treatment. Results. A significant decrease in body weight, BMI, waist circumference, fat mass, uric acid level and metabolic indices as well as significant improvement in lipid profile with exception of HDL cholesterol level were found. The effect of DASH diet and physical activity was beneficial irrespective of age, gender and baseline presence of hypertension. Conclusion. Implementation of healthy lifestyle was associated with significant improvement in anthropometric and metabolic parameters. It seems necessary to increase the public awareness of the role of behavioral changes to improve the health-related outcomes.
Gniewkowo Women Study
(2017) Dereziński, Tadeusz; Zozulińska-Ziółkiewicz, Dorota; Uruska, Aleksandra; Dąbrowski, Mariusz
Risk factors for cancer development in type 2 diabetes. A retrospective case-control study.
(2016-08-19) Dąbrowski, Mariusz; Szymańska-Garbacz, Elektra; Miszczyszyn, Zofia; Dereziński, Tadeusz; Czupryniak, Leszek
Abstract Background. The risk of several types of cancer is increased in type 2 diabetes mellitus. The earliest possible diagnosis of cancer – difficult within regular outpatient diabetes care - is of utmost importance for patients’ survival. The aim of this multicenter, retrospective (years 1998-2015), case-control study was to identify risk factors associated with malignancy in subjects with diabetes treated in a typical outpatient setting. Methods. In the databases of 3 diabetic and 1 primary care clinics 203 patients (115 women) with type 2 diabetes mellitus who developed malignancy while treated for diabetes were identified. The control group consisted of 203 strictly age- and gender matched subjects with type 2 diabetes without cancer. Factors associated with diabetes: disease duration, antidiabetic medications use and metabolic control of diabetes were analyzed. Also other variables: BMI (body mass index), smoking habits, place of residence and comorbidities were included into analysis. Results. The most prevalent malignancies in men and women together were breast cancer (20.7%) and colorectal cancer (16.3%). HbA1c (hemoglobin A1c) level ≥8.5%, obesity and insulin treatment in dose-dependent and time-varying manner demonstrated significant association with increased risk of malignancy, while metformin use was associated with a lower risk of cancer. Diabetes duration, comorbidities, smoking habits, place of residence and aspirin use did not show significant association with risk of malignancy. Conclusions. In the outpatient setting the obese patients with poorly controlled insulin treated type 2 diabetes mellitus should be rigorously assessed towards malignancies, particularly breast cancer in women and colorectal cancer in men.

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Przeglądanie Sprawozdania, raporty (KNM) / Reports (CoMS) według Autor "Dąbrowski, Mariusz"