Evaluation of platelet indexes as potential biomarkers of suspected pulmonary embolism

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dc.contributor.authorWójcik, Mariusz
dc.contributor.authorDaszyk-Wójcik, Joanna
dc.contributor.authorSkoczyński, Kamil
dc.date.accessioned2019-07-15T11:12:09Z
dc.date.available2019-07-15T11:12:09Z
dc.date.issued2019
dc.description.abstractIntroduction. Pulmonary embolism is one of the most frequent cardiovascular diseases, potentially leading to death. There is no validated biomarker with both high specificity and sensitivity. Aim. The aim of the study was to define the diagnostic importance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) on acute pulmonary embolism. Material and methods. We retrospectively reviewed the medical records of 145 patients with clinically suspected acute pulmonary embolism admitted to the Emergency Department. Demographic data and laboratory tests were collected on admission. All patients underwent computed tomography (CT) angiography. Results. The total data of 145 patients were analyzed, including 65 patients (67±17 years; 30 men/35 women) with acute pulmonary embolism confirmed with CT and 80 patients (67±19 years; 26 men/54 women) with negative CT. The MPV did not differ between the patients with acute PE and the control group (8.0 fL [IQR: 7.6-8.4] vs. 7.9 fL [IQR: 7.4-8.7], p=0.45). There were no significant differences in PLT (220x103/mm3 [IQR: 172-274] vs. 243x103/mm3 [IQR: 186-286], p=0.12) and PDW (59.0 ± 6.9% vs. 57.2 ± 7.3%, p=0.12). Conclusions. Our results suggest that platelet indexes (at a single time point) are not a reliable diagnostic biomarkers of acute pulmonary embolism.pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 17, z. 2 (2019), s. 113–117pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2019.2.1
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/4752
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmean platelet volumepl_PL.UTF-8
dc.subjectplatelet countpl_PL.UTF-8
dc.subjectplatelet distribution widthpl_PL.UTF-8
dc.subjectpulmonary embolismpl_PL.UTF-8
dc.titleEvaluation of platelet indexes as potential biomarkers of suspected pulmonary embolismpl_PL.UTF-8
dc.typearticlepl_PL.UTF-8
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European Journal of Clinical and Experimental Medicine T.17, z. 2 (2019)