Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients

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dc.contributor.authorArinola, Ganiyu Olatunbosun
dc.contributor.authorOnifade, Abdulfattah Adekunle
dc.contributor.authorAdigun, Kehinde
dc.contributor.authorOshingbesan, Mosunmade Babatunde
dc.date.accessioned2023-12-29T18:51:33Z
dc.date.available2023-12-29T18:51:33Z
dc.date.issued2023-12
dc.descriptionEthical approval was granted by the Institutional Ethical Committee with approval number UI/EC/20/0283.
dc.description.abstractIntroduction and aim. Coronavirus disease 2019 is characterised by cytokine storm and it was managed with repurposed drugs, however the effect of this treatment on cytokine storm is unknown. The aim of the study was to investigate the effect of repurposed management on serum Th1 pro-inflammation cytokine (IFN-γ) and Th2 anti-inflammation cytokine (IL-4) in COVID-19 patients. Material and methods. The levels of IFN-γ and IL-4 were determined in sera from 45 COVID-19 patients at admission followed-up till discharge after repurposed treatment using ELISA. The mean levels and proportions above normal reference ranges of IFN-γ and IL-4 were compared in COVID-19 at admission and discharge. Results. The mean values of IFN-γ and IL-4 were significantly higher in COVID-19 patients at admission compared with discharged COVID-19 patients whereas IFN-γ:IL-4 ratio was significantly higher in discharged COVID-19 patients compared with admitted COVID-19 patients. Significantly higher proportion of COVID-19 patients at discharge had IFN-γ within the normal reference ranges compared with COVID-19 patients at admission whereas the proportions of COVID-19 patients at discharge and COVID-19 patients at admission having IL-4 within the normal reference ranges were the same. Conclusion. Cytokine storm was evidenced in COVID-19 patients at admission and repurposed treatment suppressed pro-inflammation cytokine (IFN-γ) in most discharged COVID-19 patients.eng
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 21, z. 4 (2023), s. 750–755
dc.identifier.doi10.15584/ejcem.2023.4.14
dc.identifier.eissn2544-1361
dc.identifier.urihttps://repozytorium.ur.edu.pl/handle/item/9504
dc.language.isoeng
dc.publisherPublishing Office of the University of Rzeszow
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Poland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectcytokine storm
dc.subjectre-purposed treatment
dc.subjectSARS-CoV-2
dc.titleSerum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients
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European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023)