Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State

Obrazek miniatury
Al-Tayeb, Al-Noor Opied
Abubakr, Mohammed Hayati
Elrheima, Hafsa Ahmed
Habbani, Ahmed Khalid
Elrasul, Rami Y. Hassab
Tytuł czasopisma
Tytuł tomu
Publishing Office of the University of Rzeszow
Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group. Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001. Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
The study was approved by the ethical committees of the University of Medical Sciences and Technology (IRB UMST/EG/2022/18, approval date 11/01/2022). Verbal consents were obtained from all participants, and approval was granted by the hospital administration through the office of the medical director.
Słowa kluczowe
aminotransferases , creatinine , methamphetamine , urea
European Journal of Clinical and Experimental Medicine T. 22, z. 1 (2024), s. 68–72