Assessment of hepatorenal biochemical indices in male Sprague Dawley rats preceding concurrent oral administration of Ghana alcoholic bitters and natural cocoa powder

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dc.contributor.authorMaalman, Raymond Saa-Eru
dc.contributor.authorBimpong, Samuel
dc.contributor.authorAbaidoo, Chrissie Stansie
dc.contributor.authorCuba, Magalys Lopez
dc.contributor.authorKumi, Michael Barima
dc.contributor.authorSarkodie, Francis Kofi
dc.date.accessioned2024-03-29T19:20:21Z
dc.date.available2024-03-29T19:20:21Z
dc.date.issued2024
dc.descriptionEthical approval was obtained from the Committee on Human Research, Publication, and Ethics of the School of Medicine and Dentistry, Science Kwame Nkrumah University of Science and Technology, with reference number: CHRPE/RC/205/17.
dc.description.abstractIntroduction and aim. There has been a surge in the consumption of Ghanaian alcoholic bitters. Ghanaian alcoholic bitters are formulated from a maceration of not less than three plant parts making the organic composition very complex. There appear to be no studies on the effect of Ghanaian alcoholic bitters on the hepatorenal biochemistry indices. The study aimed to assess the effects of alcoholic bitters and cocoa powder on the liver and kidney serum biochemistry. Material and methods. Twenty-four healthy male Sprague Dawley rats, age 11–12 weeks, weighing 150–250 g were used. The rats were randomly assigned to four groups (n=6). At the end of the experimentation, a blood sample was taken by cardiac puncture and centrifuged to obtain the serum for biochemical assays and analysis. Results. The liver enzymes showed no significant difference between the treatment and control groups. There were higher mean values for total bilirubin and direct bilirubin for alcoholic bitters and natural cocoa powder groups respectively than the control group and the co-administration of alcoholic bitters and natural cocoa powder group. Conclusion. The study concludes that alcoholic bitters consumption might cause injury to the liver and kidney resulting in anomaly of the hepatorenal indices from rat blood serum biochemistry.eng
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 22, z. 1 (2024), s. 121–127
dc.identifier.doi10.15584/ejcem.2024.1.23
dc.identifier.eissn2544-1361
dc.identifier.urihttps://repozytorium.ur.edu.pl/handle/item/10366
dc.language.isoeng
dc.publisherPublishing Office of the University of Rzeszow
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Poland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectbiochemistry
dc.subjectGhanaian alcoholic bitters
dc.subjecthepatorenal indices
dc.subjectnatural cocoa powder
dc.subjectSprague Dawley rat
dc.titleAssessment of hepatorenal biochemical indices in male Sprague Dawley rats preceding concurrent oral administration of Ghana alcoholic bitters and natural cocoa powder
dc.typearticle
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European Journal of Clinical and Experimental Medicine T.22, z. 1 (2024)