Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

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dc.contributor.authorBober, Zuzanna
dc.contributor.authorAebisher, David
dc.contributor.authorTabarkiewicz, Jacek
dc.contributor.authorGuz, Wiesław
dc.contributor.authorTutka, Piotr
dc.contributor.authorBartusik-Aebisher, Dorota
dc.date.accessioned2017-12-12T10:01:03Z
dc.date.available2017-12-12T10:01:03Z
dc.date.issued2017
dc.description.abstractCurrently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 15, z. 2 (2017), s. 99–108pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2017.2.2
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/3186
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectdrug delivery systemspl_PL.UTF-8
dc.subjectdrug formspl_PL.UTF-8
dc.subjectmagnetic resonance imagingpl_PL.UTF-8
dc.subjectpharmaceuticalspl_PL.UTF-8
dc.titleInvestigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopypl_PL.UTF-8
dc.typearticlepl_PL.UTF-8
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European Journal of Clinical and Experimental Medicine T.15, z. 2 (2017)