Genetic variants of the glucagon-like receptor-1 in obesity

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dc.contributor.authorNikulina, Anna
dc.date.accessioned2023-12-29T12:46:01Z
dc.date.available2023-12-29T12:46:01Z
dc.date.issued2023-12
dc.descriptionHuman Research Ethics Committee of Dnipro State Medical University, Ukraine (meeting minutes No. 7 of December 11, 2019 and minutes from meeting No. 4 of September 2, 2020).
dc.description.abstractIntroduction and aim. Dysfunction of the glucagon-like peptide 1 (GLP-1)/GLP-1 receptor (GLP-1R) axis promotes obesity and metabolic disorders. The aim was to study the associations of the single nucleotide variants (SNV) GLP1R gene with proinflammatory cytokines and metabolic disorders in children with various obesity phenotypes. Material and methods. 252 children with obesity aged 6-18 years were examined. The first group (n=152) was represented by children with metabolically unhealthy obesity (MUO). The second group (n=100) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 52 children. Results. An association with the development of obesity was noted for T alleles rs61754624 (t=3.33) and rs10305457 (t=2.06); with MUO – for C alleles rs1042044 (t=2.23), rs1126476 (t=2.63), rs2235868 (t=2.82); T alleles rs61754624 (t=3.33), rs10305457 (t=2.06) GLP1R, p<0.05. In the MHO group, a correlation was found with the levels of pro-inflammatory markers IL-1β, IL-6 in the presence of the GA genotype SNV rs3765468; with hyperglycemia - GA genotype SNV rs6923761, CC genotype SNV rs1042044, AA rs6918287; hyperinsulinemia - GA genotype SNV rs3765468, GG rs10305421; triglyceridemia - AA rs6918287 of GLP1R. Conclusion. SNV rs1042044, rs3765468, rs6923761, s6918287, and rs rs10305421 GLP1R are associated with the development of MUO in individuals with MHO.eng
dc.description.sponsorshipThe work is a fragment of the research work of the De partment of Pediatrics 1 and Medical Genetics of the Dnipro State Medical University “Prediction of the development of childhood diseases associated with civilization” (No 0120U101324). The study was carried out according to the budget program of the Code of program classification of expenses and crediting 2301020 “Scientific and scientific and technical activities in the field of health care”, funded by the Ministry of Health of Ukraine from the state budget. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 21, z. 4 (2023), s. 682–691
dc.identifier.doi10.15584/ejcem.2023.4.16
dc.identifier.eissn2544-1361
dc.identifier.urihttps://repozytorium.ur.edu.pl/handle/item/9494
dc.language.isoeng
dc.publisherPublishing Office of the University of Rzeszow
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Poland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectanalysis of single nucleotide gene variants
dc.subjectchildren
dc.subjectglucagon-like peptide-1 receptor
dc.subjectmetabolically healthy obe- sity
dc.subjectmetabolically unhealthy obesity
dc.titleGenetic variants of the glucagon-like receptor-1 in obesity
dc.typearticle
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European Journal of Clinical and Experimental Medicine T.21, z. 4 (2023)