The expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cells

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dc.contributor.authorDonmez Cakıl, Yaprak
dc.contributor.authorOzunal, Zeynep Gunes
dc.contributor.authorKayalı, Damla Gokceoglu
dc.contributor.authorAktas, Ranan Gulhan
dc.date.accessioned2021-03-15T10:52:31Z
dc.date.available2021-03-15T10:52:31Z
dc.date.issued2021
dc.description.abstractIntroduction. Cancer is a leading cause of mortality. Hepatocellular cancer is one of the malignancies associated with poor outcome and resistance to pharmacotherapy. Cancer stem cells (CSCs) contribute to resistance to therapy and hence lead to the treatment failure of tumors. Aim. This study aims to explore the expression of CSCs in response to cisplatin treatment in HepG2 hepatocellular cancer cell line. Material and methods. Cell proliferation test, CCK-8, was used to evaluate the cell proliferation following cisplatin treatment for 72 hours. The expressions of CSC markers CD44, CD90, and CD133 were assessed by flow cytometric analysis. Results. The results showed a dose-dependent decrease in cell proliferation and increased expression of CSC markers CD44 and CD90 in response to cisplatin. Conclusion. Understanding the roles of CSC markers may point to new targets and therapeutic strategies to predict and overcome cisplatin resistance.pl_PL.UTF-8
dc.description.sponsorshipThis study was funded by Maltepe University Research Project Council (Grant date 18.02.2019).pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 19, z. 1 (2021), s. 18–22pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2021.1.3
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/6118
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcancerpl_PL.UTF-8
dc.subjectcisplatinpl_PL.UTF-8
dc.subjecthepatocellularpl_PL.UTF-8
dc.subjectstem cellspl_PL.UTF-8
dc.titleThe expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cellspl_PL.UTF-8
dc.typearticlepl_PL.UTF-8
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European Journal of Clinical and Experimental Medicine T.19, z. 1 (2021)