Repozytorium UR

Fibrodysplasia Ossificans Progressiva – a presentation of cases and literature review

DSpace Repository

Show simple item record Dąbrowska, Małgorzata Dąbrowski, Piotr Tabarkiewicz, Jacek 2019-07-16T08:08:25Z 2019-07-16T08:08:25Z 2019
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 17, z. 2 (2019), s. 184–191 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.description The authors thank prof. Frederick Kaplan (The Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine and Chief of the Division of Molecular Orthopaedic Medicine at the University of Pennsylvania School of Medicine) for inspirations, directions and discussion during writing this article. The authors thank prof. David Aebisher for his help in text editing and English corrections. pl_PL.UTF-8
dc.description.abstract Introduction. Fibrodysplasia ossificans progressiva (FOP) is a very rare inherited disease leading to progressive ectopic ossification of muscle and soft tissue and resulting in severe immobilisation and premature death. The mutations in ACVR1 gene that codes the 1A activin receptor which belongs to the family of bone morphogenetic proteins (BMPs) are leading to clinical symptoms. Aim. In this raport we present 3 cases of paediatric FOP patients presenting varied clinical course of disease. Description of the cases. Case 1. A girl, currently 5 years old, was hospitalised for the first time at the age of 10 months with suspicion of a hyperplastic lesion of the left lumbar area. The time period between the first symptom, i.e. subcutaneous oedema, and the correct diagnosis was about 8 months. The symptom with key importance for the diagnosis was congenital deformities of the thumbs and big toes. Case 2. A 6-year-old girl with a congenital hallux valgus in both feet, a small painless nodular lesion in the area of the distal metaphysis of the femur, limiting the flexion of the knee joint, was diagnosed in the third month of life. Case 3. A three-year-old girl was diagnosed with congenital defects i.e. hallux valgus of both feet. The first symptoms of the disease occurred during her 14th month when an oedema of the subcutaneous tissue of the nape area was observed. Conclusion. Until recently, there has been no efficient therapy which could slow down the natural course of the disease and currently the disease is treated as incurable. Of key importance from the perspective of patients is early diagnosis and, more importantly, preventing traumas, surgical procedures, intramuscular injections, sparing dental treatment and ensuring avoidance of airway tract infections. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe *
dc.rights.uri *
dc.subject clinical course pl_PL.UTF-8
dc.subject diagnostic difficulties pl_PL.UTF-8
dc.subject ectopic ossification pl_PL.UTF-8
dc.subject fibrodysplasia ossificans progressiva pl_PL.UTF-8
dc.title Fibrodysplasia Ossificans Progressiva – a presentation of cases and literature review pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2019.2.14
dc.identifier.eissn 2544-1361

Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe

Search DSpace


My Account