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Expression of heat shock protein 70 in the tissue of patients with laryngeal squamous cell carcinoma

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Show simple item record Barańska, Aleksandra Maziarz, Aleksandra Roliński, Jacek Klatka, Janusz Dudzińska-Ćwiek, Katarzyna Tabarkiewicz, Jacek 2019-04-08T12:34:59Z 2019-04-08T12:34:59Z 2019
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 17, z. 1 (2019), s. 16–21 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.description.abstract Introduction. Laryngeal squamous cell carcinoma (LSCC) is a common type of head and neck malignancy. Because of unsatisfactory results of therapy, development of new strategies for LSCC treatment is needed. It is believed that heat shock protein 70 (HSP70) is involved in pathogenesis of LSCC. Thus, targeting HSP70 seems to be promising strategy for laryngeal cancer treatment. Aim. The aim of the study was to assess the HSP70 concentration in laryngeal squamous cell carcinoma specimens and its correlation with tumor volume and TNM staging. Material and methods. An ELISA method and a Bradford protein assay were used to evaluate the HSP70 concentration in peripheral blood cells, tumor tissue and lymph nodes from the patients suffering from LSCC. Results. We demonstrated that the HSP70 concentration is significantly different between examined compartments. The highest level was observed in peripheral blood, while the lowest was in the lymph nodes. The HSP70 expression was correlated to tumor volume. Conclusion. Our results showed varied expression of HSP70 in tissue from patients with LSCC, but there was no association between HSP70 concentration and TNM staging. Currently, application of HSP70 inhibition as a LSCC treatment could be rather associated with systemic blocking of this molecule than target inhibition in tumor tissue. However, further analysis on a larger group of patients is needed. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe *
dc.rights.uri *
dc.subject HSP70 pl_PL.UTF-8
dc.subject LSCC pl_PL.UTF-8
dc.subject treatment pl_PL.UTF-8
dc.title Expression of heat shock protein 70 in the tissue of patients with laryngeal squamous cell carcinoma pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2019.1.3
dc.identifier.eissn 2544-1361

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Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe

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