Repozytorium UR

Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

Repozytorium Centrum Otwartej Nauki

Pokaż uproszczony rekord

dc.contributor.author Sęk-Mastej, Anna
dc.contributor.author Galiniak, Sabina
dc.contributor.author Krawczyk-Marć, Izabela
dc.contributor.author Balawender, Krzysztof
dc.contributor.author Szymczak, Artur
dc.contributor.author Kaniewski, Maciej
dc.contributor.author Leksa, Natalia
dc.contributor.author Biesiadecki, Marek
dc.contributor.author Orkisz, Stanisław
dc.date.accessioned 2018-09-24T07:17:25Z
dc.date.available 2018-09-24T07:17:25Z
dc.date.issued 2018
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 16, z. 2 (2018), s. 85–91 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.identifier.uri http://repozytorium.ur.edu.pl/handle/item/3886
dc.description.abstract Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject pregnancy pl_PL.UTF-8
dc.subject foetus pl_PL.UTF-8
dc.subject congenital defect pl_PL.UTF-8
dc.subject teratogen pl_PL.UTF-8
dc.title Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2018.2.1
dc.identifier.eissn 2544-1361


Pliki tej pozycji

Z tą pozycją powiązane są następujące pliki licencyjne:

Pozycja umieszczona jest w następujących kolekcjach

Pokaż uproszczony rekord

Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe Poza zaznaczonymi wyjątkami, licencja tej pozycji opisana jest jako Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe

Szukaj w Repozytorium UR


Przeglądaj

Moje konto

Statystyki

Informacje