Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

Skrócona strona pozycji
dc.contributor.authorSęk-Mastej, Anna
dc.contributor.authorGaliniak, Sabina
dc.contributor.authorKrawczyk-Marć, Izabela
dc.contributor.authorBalawender, Krzysztof
dc.contributor.authorSzymczak, Artur
dc.contributor.authorKaniewski, Maciej
dc.contributor.authorLeksa, Natalia
dc.contributor.authorBiesiadecki, Marek
dc.contributor.authorOrkisz, Stanisław
dc.date.accessioned2018-09-24T07:17:25Z
dc.date.available2018-09-24T07:17:25Z
dc.date.issued2018
dc.description.abstractIntroduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 16, z. 2 (2018), s. 85–91pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2018.2.1
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/3886
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectpregnancypl_PL.UTF-8
dc.subjectfoetuspl_PL.UTF-8
dc.subjectcongenital defectpl_PL.UTF-8
dc.subjectteratogenpl_PL.UTF-8
dc.titleInfluence of Adriblastin and Bleomycin on Wistar rat mothers and fetus developmentpl_PL.UTF-8
dc.typearticlepl_PL.UTF-8
Pliki
Oryginalny pakiet
Aktualnie wyświetlane 1 - 1 z 1
Obrazek miniatury
Nazwa:
1 sęk-mastej-influence of adriblastin.pdf
Rozmiar:
169.3 KB
Format:
Adobe Portable Document Format
Opis:
Pobierz
Pakiet licencji
Aktualnie wyświetlane 1 - 1 z 1
Obrazek miniatury
Nazwa:
license.txt
Rozmiar:
1.22 KB
Format:
Item-specific license agreed upon to submission
Opis:
Pobierz
Kolekcje
European Journal of Clinical and Experimental Medicine T.16, z. 2 (2018)