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An overview of the preclinical and clinical studies of the effects of tumor treating fields on malignant glioma cells

Repozytorium Centrum Otwartej Nauki

Pokaż uproszczony rekord Bądziul, Dorota Banaś-Ząbczyk, Agnieszka Tabarkiewicz, Jacek 2017-12-12T11:14:53Z 2017-12-12T11:14:53Z 2017
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 15, z. 2 (2017), s. 141–144 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.description.abstract Anaplastic astrocytoma (AA, WHO grade III) and glioblastoma multiforme (GBM, WHO grade IV) are malignant tumors of the brain. The average survival time of patients with GMB is approximately one year and two years in the case of anaplastic astrocytoma with standard therapy based on surgical tumor resection followed by chemotherapy or radiotherapy. High invasiveness of gliomas, the ability of rapid division and so-called diffusive infiltration of tumor cells into normal brain tissue, which prevents complete surgical removal, are hallmarks of theses tumors. Therefore, new specific therapies for eliminating cancer cells are needed to treat this tumors. Recently, it has been demonstrated that alternating electric field, also known as tumor treating fields (TTFields) has a unique mechanism of destroying glioma cells. TTFields applies electromagnetic energy frequency-dependent and intensitydependent and disrupts cancer cell replication as they undergo mitosis. Futhermore, TTFields turn out to act comparably to conventional chemotherapeutics, lacking numerous side adverse associated with chemotherapy. The authors provide an up-todate review of the mechanism of action as well as preclinical and clinical data on TTFields. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe *
dc.rights.uri *
dc.subject anaplastic astrocytoma pl_PL.UTF-8
dc.subject glioblastoma multiforme pl_PL.UTF-8
dc.subject brain tumor pl_PL.UTF-8
dc.subject tumor treating fields pl_PL.UTF-8
dc.subject tumor therapy pl_PL.UTF-8
dc.title An overview of the preclinical and clinical studies of the effects of tumor treating fields on malignant glioma cells pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2017.2.7
dc.identifier.eissn 2544-1361

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