European Journal of Clinical and Experimental Medicine T.20, z. 2 (2022)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/8068

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Aktualnie wyświetlane 1 - 14 z 14

Food delivery rider and COVID-19 as a preventive measure – increased safety or risk?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Sookaromdee, Pathum; Wiwanitkit, Viroj
IgG4 related orbital/ophtalmic disease in COVID-19 after improving from critical pneumonia
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Erok, Berrin; Mansuroğlu, İlknur; Keklikoğlu, Taha Oğuz; Önder, Hakan
The importance of electroencephalography in the diagnosis of hepatic encephalopathy due to cirrhosis – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Fuksa, Katarzyna
Introduction and aim. Hepatic encephalopathy (HE) associated with cirrhosis of the liver is a neuropsychiatric syndrome, with symptoms ranging from barely detectable changes to deep coma. It frequently occurs in the form of episodes and relapses and can be triggered by external factors. HE severity is graded according to the West Haven criteria. The aim of the study is to draw attention to the ever-important and often key role of electroencephalography in the diagnosis of hepatic encephalopathy, even in today’s era of increasingly advanced diagnostic methods. Description of the case. A 57-year-old patient, professionally active at the time, was admitted to the hospital’s Neurology Department on an emergency basis due to difficulties with standing and moving, orientation disorders and limb tremor. Conclusion. While HE pathogenesis is multifactorial, the most important factors include increased brain exposure to ammonia, intestinal dysbiosis, and endotoxemia inducing a systemic inflammatory response. Patient observation, blood laboratory tests, neuropsychological tests and neurophysiological tests (EEG and evoked potentials) play an important role in establishing the diagnosis. Treatment and secondary prevention of hepatic encephalopathy include elimination of triggers and reduction of ammonia production and improvement of its metabolism.
Characteristics of the health-promoting properties of Cornus mas
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Nawrot, Klaudia; Polak-Szczybyło, Ewelina; Stępień, Agnieszka
Introduction and aim. The medicinal properties of Cornus mas L. have been used in European and Asian folk medicine for many centuries in the prevention and treatment of many diseases. The high biological activity of the plant results primarily from the presence of valuable ingredients, including anthocyanins, flavonoids and iridoid compounds. The aim of the article is to present the role of bioactive ingredients present in C.mas that determine its health-promoting properties. Material and methods. Review and analysis of the scientific literature. Analysis of the literature. The summarize information about in the field of phytochemical properties and therapeutic effects, among others anticancer, antidiabetic, neuroprotective, cardioprotective and antibacterial. Conclusion. The results of many in vitro and in vivo scientific studies They indicate the possibility of the potential use of Cornelian cherry to obtain valuable nutraceutical and pharmacological substances.
Pathophysiology of thromboembolism in patients with COVID-19
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Vityala, Yethindra; Krishna, Abhijit; Pandla, Dinesh; Priya Kanteti, Krishna; Sadhu, Jahnavi; Boddeti, Harsha Vardhan; Kintali, Tejesh; Khalid, Mohammad Shaour
Introduction and aim. A small number of critically ill patients with coronavirus disease (COVID-19) develop thromboembolism (arterial or venous), both micro- and macrovascular complications such as deep vein thrombosis, pulmonary embolism, and pulmonary arterial thrombosis. The objective of the study is to describe the pathophysiology of venous thromboembolism in patients with COVID-19. Material and methods. In this article a narrative review regarding pathophysiology of thromboembolism in patients with COVID-19. Analysis of the literature. The development of coagulopathy is a consequence of the intense inflammatory response associated with hypercoagulability, platelet activation, and endothelial dysfunction. The pathophysiology that relates pulmonary thromboembolism (PTE) with COVID-19 is associated with a hypercoagulable state. PTE is suspected in hospitalized patients presenting dyspnea, decreased oxygen requirement, hemodynamic instability, and dissociation between hemodynamic and respiratory changes. In COVID-19-associated coagulopathy, initially, patients present with elevated levels of fibrinogen and D-dimer, with minimal changes in prothrombin time and platelet count. The main risk factor for the development of pulmonary embolism is the increase in D-dimer that is associated with the development of PTE. The administration of iodine-based contrast agent to patients with COVID-19 would affect P-creatinine and renal function, where Ultrasound is viewed as cost-effective and highly portable, can be performed at the bedside. Conclusion. Acute respiratory distress syndrome severity in patients with COVID-19 can explain PTE as a consequence of an exaggerated immune response.
The impact of COVID-19 pandemic and distance learning on physical and mental health of Polish students
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Mołoń, Mateusz; Janda, Małgorzata
Introduction and aim. In Poland, on 25 March 2020, distance learning, which for many people was known only from literature, entered into force. As a result, education could no longer be provided in its current form and was therefore provided online. Therefore, the main aim of the presented research was an attempt to verify the pandemic and distance education impact on students psychophysical conditions and satisfaction. Material and methods. Some primary school students (grades 6th-8th), secondary school students from the Subcarpathian Voivodeship in Poland and also some university students from foreign countries completed an anonymous survey on the impact of the COVID-19 pandemic on their physical and mental condition as well as on some aspects of distance education. The research was conducted in December 2021 and 804 students (Primary and Secondary School) and 64 university students completed the survey. Results. Both the primary and the secondary school students claimed they were quite satisfied with distance education. The mostly approved aspect of online education was the fact that the time of learning was fitted to students’ needs. Difficulties in distance learning indicated by students were mainly connected with their mental health. Therefore, many students suffered from mental health and concentration problems, unwillingness to be active, apathy. The pandemic was also a stress factor for students and a reason why they were in a bad mood. The pandemic was the reason for an increased interest in natural sciences among 31.3% of primary school students, among 20.8% of secondary school students and among 17.3% of university students from foreign countries. Distance education influenced physical health of almost half of the respondents in both types of schools. The pandemic had an impact on mental health state of almost half of primary school students. 65% of secondary school students said that the pandemic influenced both their mental and physical health. In case of university students the pandemic did not influence their physical health in a significant way (65.4%). The study shows that primary school students used the Internet mainly to play games (almost 50% of the respondents), watch films, listen to music, do homework. Online lessons were only 20% of the answers. Conclusion. There has been a significant impact of COVID-19 on students in elementary school, high school, and university. This resulted in negative mental and physical effects. Respondents were stressed, depressed, and unmotivated. Approximately half of them engaged in physical activity very rarely or rarely. Even though they were satisfied with online learning, which was caused by the COVID-2019 pandemic, the greatest problem was mental concentration problems, lack of motivation, and social isolation.
The outcomes in children with Hirschsprung’s disease treated with transanal endorectal pull-through method
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Szymczak, Artur; Ogorzałek, Anna; Leksa, Natalia; Sęk-Mastej, Anna; Orkisz, Stanisław
Introduction and aim. The evaluation of functional results, complications and problems of children with Hirschsprung’s disease treated with one-stage surgery (TEPT) or two-stage surgery (colostomy, TEPT) in Paediatric Surgery Clinic in Rzeszow. Material and methods. Medical documentation of 41 children treated due to Hirschsprung’s disease in years 2006-2018 in Rzeszow were retrospectively analysed. The results of the questionnaires conducted among the parents of operated children were surveyed. Results. The average time of the radical surgery was 189 minutes. The mean length of the resected intestine in the classic form was 19 centimeters, in long-segment 35 centimeters. In the post-operative period, 15 patients had a blood transfusion. The mean time of the children’s stay calculated from the date of surgery until the discharge equaled 13.4 days. Early post-operative complications: enterocolitis occurred in 6 patients (1 death in a septic shock mechanism), total dehiscence of anastomosis in 1 patient, abscess of perirectal space in 1 patient, anastomotic retraction in 1 patient and in 3 patients inaccurate intra-operative evaluation of the section (intra), buttock dermatitis appeared in all patients. Late post-operative complications (a control trial of 38 patients): Soiling was confirmed in 9 patients, periodic constipation in one. The abnormal consistency of stool was signaled in 3 children. Two children were repetitively hospitalized due to enterocolitis. The frequency of defecation almost in all patients was reduced after a three, four-month period since the operation from 10-15 per day to the age norm. In one child, where the retraction of the anastomosis was diagnosed, the soiling and heightened frequency of defecation throughout the day persists. All of the parents of the older children view the outcome of the surgery as positive and the life quality of their children does not differ from their peers. Conclusion. TEPT is a method which can be performed in newborns, infants, babies as well as in case of a long-segment aganglionosis. Barium enema is not reliable in evaluation of the length of the aganglionic section in the long-segment type of Hirschsprung’s disease. The treatment of choice in the early post-operative enterocolitis should be colostomy. Worse functional results were observed in children after two-stage treatment – especially, in cases where the colostomy was created due to the intestinal re-distention.
Intraarticular administration of chondroitin sulfate in experimental osteoarthritis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Nosivets, Dmitriy
Introduction and aim. Osteoarthritis (OA) is generally a progressive disease that affects synovial joints, resulting in abnormalities to articular cartilage subchondral bone, synovium, and adjacent soft tissues. The purpose of this work was to investigate the specific activity of chondroitin sulfate (CS) in intra-articular and intramuscular administration to laboratory rabbits in experimental OA. Material and methods. OA was induced in rabbits by a single injection of mono-iodoacetate in knee joint. CS was administered intra-articularly and intramuscularly. The analysis of biochemical markers and macroscopic assessment of rabbit knee joints was performed. Results. Intramuscular and intra-articular injection of CS reduces the intensity of the degenerative-dystrophic process due to the impact on inflammatory and the activation of anabolic mechanisms. Intra-articular administration of CS leads to a greater increase in the level of factors of bone and cartilage formation and a greater decrease in the levels of factors of the acute phase of inflammation and factors that destroy the cartilage matrix. Conclusion. Intramuscular administration of CS revealed a lower intensity of destructive changes in the cartilaginous surface of the knee joint, and intramuscular – the absence of cartilage destruction and defects of the cartilaginous surface, which indicates the peculiarity of the topical effect of the CS.
The effects of mother’s voice and white noise on APGAR scores of newborns and attachment processes – a randomized controlled trial
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Aközlü, Zeynep; Şahin, Özlem Öztürk
Introduction and aim. The present study aims to determine the effects of mother’s voice and white noise on newborns’ APGAR scores and attachment processes. Material and methods. The current study was a randomized controlled trial and concluded with 87 newborns and their mothers who had given elective cesarean section (mother voice=29; white noise=28; and control group=30). The mother voice and white noise groups were exposed to recordings, and the broadcast continued for five minutes. The APGAR scores and attachment indicators of newborns (eye contact, rooting, and latch-on) of all groups were examined by the Newborn Attachment Indicators Observation Form. Results. The 1st and 5th minute APGAR scores in control group were lower than mother voice (1st p=0.05; 5th p=0.001) and white noise (1st p=0.015; 5th p=0.002) groups. The rooting ratio was higher in mother voice and white noise than in the control group (p=0.004). The newborns in the control group had lower latching on rates than mother voice and white noise (p=0.002) groups. Both mother voice and white noise positively affected APGAR scores, rooting, and latching. However, only mother voice had a positive effect on all attachment indicators. Conclusion. Mother voice and white noise listened to by the newborns born with a cesarean section right after birth in their early-period care positively affect APGAR scores; furthermore, mother voice positively affects attachment indicators as first successful sucking time and eye-to-eye contact.
The effect of foot reflexology applied to neonates before oro/nasopharyngeal suctioning on procedural pain and comfort in the neonatal intensive care unit
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Ortakaş, Nesrin Elif; Şahin, Özlem Öztürk
Introduction and aim. This study was performed to examine the effect of foot reflexology applied to the neonates on the level of pain and discomfort developed due to suctioning procedure. Material and methods. The study was conducted experimentally by taking pretest and repeated measurements on reflexology and control groups determined by simple randomization. The study was carried out with 66 neonates (reflexology applied: 33 and control group: 33). Neonatal Information Form, Neonatal Infant Pain Scale (NIPS) and Newborn Comfort Behavior Scale (NCBS) were used as the data collection tools. Results. The during (p<0.001) and after suctioning (p<0.001), the NIPS scores of the neonates in the intervention group was statistically lower than the control group. The NCBS scores of the neonates in the intervention group during (p<0.001), and after suctioning (p<0.001), were statistically significantly lower than the control group. Conclusion. It was concluded that foot reflexology applied to neonates was effective both in reducing pain during and after the suctioning and in increasing comfort during and after the suctioning.
Histological aspects of whole-body vibration in the knee remobilization of Wistar rats
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Roncini Gomes da Costa, Juliana; Freitas Tavares de, Alana Ludemila; Bertolini, Gladson Ricardo Flor ; Wutzke, Maria Luiza Serradourada; Boaro, Carolina De Toni; Rodriguez, Diego Francis Saraiva; Costa, Rose Meire; de Fátima Chasko Ribeiro, Lucinéia
Introduction and aim. The knee is one of the joints where immobilization is most used, however, it can cause morphological changes in the joint tissues and is a challenge to be overcome during rehabilitation. Whole-body vibration (WBV) is capable of generating repetitive oscillatory movements, which cause mechanical stimuli that interfere with tissue plasticity. The aim of this study was to analyze the knee morphology of Wistar rats submitted to remobilization with WBV. Material and methods. 32 male rats were used, divided into four groups (n=8): Control Group (G1), Immobilization Group (G2), Immobilized Group and Free Remobilization (G3), Remobilized Group with WBV (G4). For immobilization, a plastered apparatus was used for 15 days. G3 and G4 carried out free remobilization or with WBV, respectively, for 2 weeks. The knee joints were processed for light microscopy. Results. The WBV led to a reduction in the inflammatory infiltrate in the articular cavity and greater presence of adipocytes in the subintima of the synovial membrane. Conclusion. Remobilization with WBV induced a better tissue response in the synovial membrane when compared to free remobilization.
Complementary and alternative methods of increasing breast milk of mothers of children aged 0-24 months
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Top, Fadime Üstüner; Çam, Hasan Hüseyin
Introduction and aim. Some applications are made to increase the breast milk. This study has been conducted to determine the complementary and alternative methods to increase the breast milk of mothers with a child in the age of 0 to 24 months. Material and methods. This study was conducted using the cross-sectional study design. The questionnaire included mothers’ socio-demographic characteristics, obstetric histories, breastfeeding, and practices to increase breast milk. Results. The mean age of the mothers was 29.75±}5.97 years. 23.4% of the mothers stated that they did not continue breastfeeding; the mean duration of breastfeeding was 9.24±}4.88 months. Mothers expressed to increase milk intake water/liquid food to increase (84.2%), frequently breastfed babies (43.3%), boiling greens to drink (34.6%), spiritual practices (12.8%). Mothers stated that the special drinks used to increase their milk were fennel (56.2%), instant milk enhancer (22.9%), and sage (8.9%). Mothers emphasized that the amount of water (85.1%) and sugar levels (50.0%) they consumed the most increased breast milk. Conclusion. It was determined that children could not have enough breast milk until the age of two; the mean duration of breastfeeding was low. Mothers believe that their breast milk is not enough for their children, so they apply milk-increasing practices.
The impact of the COVID-19 pandemic on critically ill patients with acute stroke and diabetic ketoacidosis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Kılıç, Mazlum; Tekyol, Davut
Introduction and aim. This study aimed to compare the hospitalization rate, mortality rate and morbidity status of patients hospitalized with stroke and diabetic ketoacidosis (DKA) before and during the COVID-19 pandemic. Material and methods. The data of 2522 patients who applied to the emergency department (ED) before and during the pandemic were evaluated. A Poisson regression analysis was used to examine the number of presentations between two different periods. Results. Stroke cases during the pandemic era were compared to those during the pre-pandemic period, and it was shown that the mortality rate for stroke patients during the pandemic period was much higher. Treatment-related ED presentations decreased significantly during the pandemic period, particularly among patients aged 75–84 years. Rates of ED presentation decreased by 84 percent (IRR: 0.14, 95 percent CI: 0.03-0.59) in those with DKA and by 37 percent (IRR: 0.67, 95 percent CI: 0.53- 0.75) in those with stroke during the pandemic period. Conclusion. Conclusion: Stroke and DKA admissions decreased during the pandemic, but the rate of stroke mortality increased statistically 3.375 times. Getting emergency medical care increases their chances of survival. Even in a COVID-19 outbreak, treatment is critical.
A family screening of CD19 gene mutation by PCR-RFLP
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Karaselek, Mehmet Ali; Kapaklı, Hasan; Güner, Şükrü Nail; Kurar, Ercan; Küççüktürk, Serkan; Keleş, Sevgi; Reisli, İsmail
Introduction and aim. Mutation(s) in the gene encoding the CD19 molecule affect CD19 protein expression and primary immunodeficiency (PID) occurs. The PCR-RFLP method, which is faster and cheaper than other mutation detection methods, is rarely used in the diagnosis of PID. The study aimed to genetically identify CD19 deficiency, which is a PID, using the PCR-RFLP method. Material and methods. A total of 8 patients and two healthy controls were included in the study and the relevant region genotypes in the CD19 gene were determined by performing PCR-RFLP analysis. Results. The index case, newborn baby and mother were also included in the study. It was determined that the index case (P6) was homozygous mutant, the newborn baby (P7) and mother (P8) had heterozygous genotype. Based on this situation, one child (P1) was found to be homozygous mutant, mother (P2), father (P3) and other children (P4 and P5) had heterozygous genotype in the family, which was determined to be related to the first case. Conclusion. In our study, it has been shown that PCR-RFLP is a method that can be used in the diagnosis of PID by determining genotypes using PCR-RFLP, and especially in terms of rapid genetic testing of family screenings.

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