European Journal of Clinical and Experimental Medicine T.16, z. 1 (2018)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/3872

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Fibromuscular dysplasia – a case description
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Leksa, Natalia; Seweryn, Bartosz; Uberman-Kluz, Dominika; Galiniak, Sabina; Kawalec, Magdalena
Introduction. Fibromuscular dysplasia is an idiopathic, non-inflammatory and non-atherosclerotic disease that affects the walls of arteries (mostly renal and carotid arteries). Histological classification distinguishes three main types of the disease, depending on the structural changes occurring in one of the three layers of arterial vessel walls. Objective. We present here a case of fibromuscular dysplasia affecting the internal carotid arteries. Case description. This article describes the case of a 52-year-old female patient with hypertension, hyperlipidemia, and a cardiac pacemaker in whom computed tomography angiography revealed a narrowing of the internal carotid arteries without atherosclerotic symptoms. We describe the diagnostic methods and various types of treatment that the patient suffering from fibromuscular dysplasia was subjected to. Conclusions. Due to a low detection rate of fibromuscular dysplasia, if the disease is suspected, all available diagnostic methods should be employed. Taking into account the unknown etiology of the disease, it is not possible to use a preventive therapy, or a therapy focused on stalling the progression of the disease.
Anticancer properties of Viburnum
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Stępień, Agnieszka; Aebisher, David; Bartusik-Aebisher, Dorota
Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
Plant medicinal products and drug interactions
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Ożóg, Łukasz; Aebisher, David; Bober, Zuzanna; Bartusik-Aebisher, Dorota
Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increased drug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature.
Physiotherapeutic management of a patient with patellofemoral pain syndrome – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Ustarbowska, Katarzyna; Trybulec, Bartosz
Introduction. Patellofemoral pain syndrome (PFPS) is a disorder of the front compartment of the knee joint with incompletely investigated, probably multifactorial pathogenesis. It mostly affects young people and runners. In patients with PFPS conservative management is a therapy of choice with fundamental importance of physiotherapeutic procedures. Therapy should be highly individualized and considering all possible factors that may cause PFPS symptoms. Aim. The aim of this report was presentation of management of a 23 year old female patient with PFPS that developed secondary to a knee sprain. The medical history, diagnostic and therapeutic procedures were thoroughly described, then obtained results were presented and thereafter discussed. Methods. Clinical assessment included functional and provocative tests of the patellofemoral joint as well as thigh and calf muscles tests, range of motion measurement of the knee joint and pain assessment using the VAS scale. Therapeutic management included 5 sessions of post-isometric muscle relaxation (PIR), mobilizations of the patella and applications of elastic tapes. Results. After 5 sessions of therapeutic management PFPS symptoms were significantly reduced. Pain did not occur during normal activity, whereas in heavy joint loading, it occurred later and was of lower intensity. Range of motion as well as subjective sense of joint stability was also improved. Conclusions. Individually adjusted conservative management based on PIR techniques, mobilizations of patella and kinesiotaping seems to be effective form of therapy for PFPS of functional nature.
Statodynamic characteristics of the spine in a sitting position
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Gruca, Maria; Saulicz, Edward
Introduction. Due to the unprecedented development of media and information technology, modern lifestyles have been changing from active to passive (sedentary). A sitting position dominates today both in the professional and the non-professional sphere of people’s life. It seems that a human does not realize what is the position of individual segments of his body, especially the torso while sitting. The torso, as the segment with the highest mass, is the source of the highest mechanical loads acting on the spine. Hence, in the habitual sitting posture, the optimal spine position has been lost. Objective. The aim of this study is to analyze statodynamic parameters of the spine in a sitting position and answer the question which of them determine the habitual sitting posture. Material and methods. The study included 372 people declaring themselves as healthy. The research program consisted of statodynamic parameters of the spine in a standing position and in 6 sitting positions: sitting position freely, favourite sitting position, sitting position with a crossed leg over the right and left thigh, and sitting position with a feet resting on the left or right knee. Results. The conducted research has shown that setting the spine in a habitual sitting posture is determined only by a change in the statodynamic parameters in the sagittal plane and generally does not depend on the range of motion in other planes. Conclusions. Habitual sitting postures are determined by the size of angles of the thoracocervical and thoracolumbar transitions as well as the size of the amplitude of the pelvic movements. The research has indicated worrying trends to misuse of kinematic redundancy in the spine while sitting in the sagittal plane.
Fundamentals of the use of Berberis as a medicinal plant
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Bober, Zuzanna; Stępień, Agnieszka; Aebisher, David; Ożóg, Łukasz; Bartusik-Aebisher, Dorota
Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis.
Ramsay Hunt syndrome with deep hearing loss and meningitis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Błochowiak, Katarzyna; Kamiński, Bartłomiej
Introduction. Ramsay Hunt syndrome is a clinical manifestation of varicella zoster virus reactivation. It is characterized by an erythematous vesicular rash in the external auditory canal and pinna with otalgia, vertigo and ipsilesional facial palsy. Symptoms develop over a few days with prodromal signs of facial weakness, tingling, facial numbness. Usually, cranial nerves VII and VIII are involved in the inflammatory process. Possible consequences of Ramsay Hunt syndrome are hearing loss, encephalitis and meningitis. Description of the case report. The authors present the case of a 63-year-old woman with a vesicular rash, earache, vertigo and left-sided facial paralysis who was treated with antiviral drugs and analgesics. These symptoms were complicated by conductive hearing loss in the left ear and meningitis. After treatment facial paralysis decreased. Unfortunately, hearing loss was permanent. Discussion. Rapid administration of antivirals and corticosteroids limited facial paralysis and improved facial expression. The prognosis for facial palsy is poorer in Ramsay Hunt syndrome than in idiopathic forms. Conclusions. A past history of vertigo and hypertension could been a predisposing factor for the severe manifestation of Ramsay Hunt syndrome and subsequent complications.
Carcinoembryonic antigen as a tumor marker in lung cancer – is it clinically useful?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Okuła, Agnieszka; Karczmarek-Borowska, Bożenna
Introduction. Lung cancer is the most common cancer in the Western world. Annually there are approximately 1.8 million new cases worldwide. It is characterized by poor prognosis with a 5-year survival of 10-17% depending on the country. Contributing to this poor prognosis is a mainly late diagnosis, as well as a fairly frequent recurrence despite radical surgery. Over the years, scientists have been searching for a tumor marker that would be useful for patients with lung cancer. Aim. The aim of this study is to discuss the significance of carcinoembryonic antigen (CEA) in the diagnosis, prognosis of the disease course, and monitoring patients with lung cancer. Methods. Review of the literature using the PubMed database, Termedia, Via Medica and the key issue: carcinoembryonic antigen as a tumor marker in lung cancer. Conclusions. Serum CEA level can be a reliable complement to the diagnosis of lung cancer. It can be helpful in preoperative prediction of disease course and qualification for adjuvant treatment of non-small cell lung cancer especially adenocarcinoma. Trends and normalization of CEA during chemotherapy have an impact on progression-free survival and overall survival (OS) of patients. Various available publications describe CEA as a marker for metastatic lung cancer, which is the most specific for metastasis in the liver and brain.
Plants – a source of therapeutic material?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Bober, Zuzanna; Stępień, Agnieszka; Aebisher, David; Ożóg, Łukasz; Bartusik-Aebisher, Dorota
Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.
Sweat lead and copper concentrations during exercise training
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Saran, Tomasz; Zawadka, Magdalena; Chmiel, Stanisław; Mazur, Anna
Introduction. Skin is the largest organ of the human body. It plays an important role in protection against harmful substances found in the surrounding environment and takes part in the elimination of heavy metals from the body by sweating. The aim of the study was to evaluate the changes in the concentration of lead and copper in the sweat collected on the first and the fourteenth day of endurance training. Materials and methods. The research included 43 patients undergoing a supervised, two-week endurance training on a cycle ergometer and cross-trainer. The lead and copper contents were presented in relation to the sodium content as an indicator of the amount of excreted sweat. Results. The lead concentration in relation to the sodium content in the samples of sweat taken with the use of swabs is statistically significantly higher on day 1 (Me = 1.64-E-4) than the 14th day (Me = 0.37-E-4) p = 0.027. In the sweat samples collected with a plaster, the lead concentration on day 14 of rehabilitation (Me = 0.08-E-4) is statistically significantly lower than before the beginning of the training cycle (Me = 1.19-E-4) p = 0.044. The concentration of copper in sweat samples collected with swabs and patches on day 1 of the rehabilitation cycle does not significantly differ from the content of samples collected on day 14. Conclusions. Endurance training with submaximal heart rate results in reduced excretion of lead in the sweat and does not significantly affect the level of copper. Further research into the impact of physical effort on the excretion of metals from the body can help explain the results.
Risk factors for overweight and obesity in pre-school children
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Polak, Ewelina; Dereń, Katarzyna; Łuszczki, Edyta; Wyszyńska, Justyna; Piątek, Adriana; Mazur, Artur
Introduction. Obesity in children and adolescents is a growing problem in the 21st century. The epidemic of chronic non-communicable diseases resulting from obesity is currently one of the biggest problems of modern medicine. Excessive body weight is the result of a long-lasting imbalance between the amount of energy supplied and its expenditure. Energy regulation of the body is subject to both genetic and environmental factors. Among other things, due to this, the problem of excessive body weight is most severe in societies with a high degree of socio-economic development. The aim of this paper is to determine the influence of selected environmental and social factors on the occurrence of overweight and obesity in pre-school children. Material and methods. The study included pre-school children from south-eastern Poland. After obtaining the consent from parents, 200 children (87 boys, 113 girls) aged 3 to 6 years were examined. A questionnaire used for the research was derived from the program: European Pilot Study Evaluating the Influence of Local Promotional Activities on Prevention of Obesity in Pre-school Children. In the subjects, body weight was measured on an electronic scale three times and the body height was measured three times using a stadiometer. Obesity was determined according to the criteria developed by the International Obesity Task Force (IOTF). Results. The prevalence of overweight and obesity among children amounted to 6.4% in 3-year-olds, 11.3% in 4-year-olds, 17.7% in 5-year-olds, and 20.7% in 6-year-olds. A factor significantly increasing the risk of obesity among the examined girls and boys was the mother’s BMI index. Conclusion. Although knowledge about the factors that promote overweight and obesity is common, it is still a common health problem. Particular attention should be paid to the prevention of obesity in children of parents with a BMI above 30 kg m2. Early maternal education can change the lifestyle of the whole family.
The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Kubrak, Tomasz; Podgórski, Rafał; Aebisher, David; Gala-Błądzińska, Agnieszka
Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.

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