Przeglądanie według Autor "Olaniyi, John Ayodele"

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Changes in haematological parameters and serum beta-2-microglobulin levels in CD4+ T-cells-stratified Nigerian HIV patients
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Olaniyi, John Ayodele; Emeka, Godwin Joseph; Onifade, Abdulfatah Adekunle; Adeyanju, Alaruru Olusoji; Rahamon, Sheu Kadiri
Introduction. Reports have shown that there is a rise in beta-2-microglobulin (β2M) concentration in patients with HIV infection and that the degree of elevation correlates well with the extent of disease burden and could be an independent prognostic marker for death. However, there is the dearth of information on the interplay between alteration in haematological profile, a common cause of morbidity and mortality in HIV, and β2M. Aim. Changes in selected haematological parameters and β2M in Nigerian HIV patients stratified based on CD4+ T-cells counts were thus assessed in this study. Material and methods. Forty-eight asymptomatic, drug naive HIV patients were enrolled into this cross-sectional study. Haemoglobin concentration (Hb), packed cell volume (PCV), total and differential white blood cell count, platelet count and CD4+ T-cells count were determined using standard methods while serum levels of β2M were determined using ELISA. Thereafter, the patients were stratified into three groups based on the CD4+ T-cells count. Results. Hb and lymphocyte counts increased with increasing CD4+ T-cells count. In contrast, neutrophils percentage, MCV and MCH reduced with increasing CD4+ T-cells count. The mean lymphocytes percentage was significantly higher while the mean neutrophils percentage was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with the patients with CD4+ T-cells count <200 cells/μl. Similarly, the mean MCV was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with patients with CD4+ T-cells count of 200–499 cells/μl and patients with CD4+ T-cells count <200 cells/μl. β2M had significant positive correlation with WBC and neutrophils percentage but had a significant negative correlation with lymphocytes percentage and MCH in patients with CD4+ T-cells count <200 cells/μl. However, β2M had significant positive correlation with PCV, Hb, monocytes and morphology in patients with CD4+ T-cells count of 500–800 cells/μl. Conclusion. It could be concluded from this study that HIV infection is associated with alteration in haematological profile and the alteration is CD4+ T-cells count-dependent. Also, elevation in β2M concentration appears to be a marker of lymphopaenia in patients with low CD4+ T-cells count.
Impact of chemotherapy on antioxidant micronutrient levels in patients with mature lymphoid malignancies
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Akunwata, Chima Uzoma; Olaniyi, John Ayodele
Introduction. Cancer treatments are now intense and are associated with nutritional deficiencies. The nutritional status of a patient may influence the tolerability of chemotherapy. Aim. We investigated the effects of chemotherapy on serum levels of trace elements (copper, iron, manganese, selenium, and zinc) and vitamins (A, C, and E) in patients with mature lymphoid malignancies (MLMs) at diagnosis and after 3 months. Material and methods. A case-control study of adults diagnosed with and treated for various MLMs. Thirty-nine cases and 39 age and sex-matched controls were recruited into this study. Venous blood samples were collected from the controls, cases at baseline and after 3 months of chemotherapy. Trace elements were determined by AAS while vitamins were determined by HPLC. Results. The levels of trace elements and antioxidant vitamins A and E were significantly higher (p<0.001) in cases than in controls while vitamin C was lower in cases compared to controls (p=0.005). After 3 months of treatment, 28 patients were available for analysis. There was a significant decline (p<0.001) in all the levels of trace elements and vitamins after chemotherapy. Conclusion. Chemotherapy is associated with a significant reduction in antioxidants levels in patients with MLMs.
Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Rahamon, Sheu Kadiri; Ganiyu, Arinola; Charles-Davies, Mabel Ayebatonyo; Akinlade, Kehinde Sola; Olaniyi, John Ayodele; Fasanmade, Adesoji Adedipe; Oyewole, Oyediran Emmanuel; Owolabi, Mayowa Ojo; Adebusuyi, Jane Roli; Hassan, Olufunke Olayemi; Ajobo, Muhammed Babatunde; Adigun, Kehinde; Ebesunun, Maria Onomaghuan; Popoola, Omolara Olutosin; Omiyale, Wemimo; Agbedana, Emmanuel Oluyemi
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.