Przeglądanie według Autor "Galiniak, Sabina"

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Adrenomyeloneuropathy – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Uberman-Kluz, Dominika; Bartosz, Seweryn; Bartusik-Aebisher, Dorota
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
An iliac artery aneurysm
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Leksa, Dawid; Gałuszka, Łukasz; Uryniak, Adam; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota
Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
Clinical aspects of protein glycation
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2017) Galiniak, Sabina; Krawczyk-Marć, Izabela; Sęk-Mastej, Anna; Leksa, Natalia; Biesiadecki, Marek; Orkisz, Stanisław
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
Cytisine parameters measured in the 1.5 Tesla magnetic field
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bober, Zuzanna; Galiniak, Sabina; Leksa, Dawid; Dynarowicz, Klaudia; Aebisher, David; Ostańska, Elżbieta; Czmil, Anna; Bar, Piotr; Bartusik-Aebisher, Dorota; Tutka, Piotr
Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substance.
Diagnostic and therapeutic difficulties of tick-borne encephalitis – a two case reports
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Przetacznik, Dominika; Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Bartosz, Seweryn; Leksa, Dawid; Bartusik-Aebisher, Dorota
Introduction. The paper presents epidemiology, routes of infection, forms of the disease, diagnostic and treatment methods, and prophylaxis of tick-borne encephalitis. Aim. In this paper, we present two descriptions of the cases of tick-borne encephalitis. Description of the cases. Case 1. A 60-year-old man with fever up to 39 degrees for 3 days, multi-site headache and other body aches, as well as an earstuck feeling. The day before hospitalization, there was a feeling of numbness on the right side of the face from eye level to the chin and speech distortion. Case 2. A 60-year-old patient with headaches and an increase in temperature to 39 degrees for 3 days, who, approximately, three weeks earlier was ticked by a tick in the lower parts of the back. Conclusion. It is also important for doctors to take a broader view and to make society aware of that Lyme disease is not associated only with Lyme disease. Further work is also needed towards effective treatments for Tick-borne encephalitis (TBE).
Epidemiology of breast cancer in Podkapackie voivodship
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Gustalik, Joanna; Bartusik-Aebisher, Dorota; Ostańska, Elżbieta; Przyczyna, Piotr; Osuchowski, Michał; Aebisher, David; Galiniak, Sabina; Kaznowska, Ewa
Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
Fibromuscular dysplasia – a case description
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Leksa, Natalia; Seweryn, Bartosz; Uberman-Kluz, Dominika; Galiniak, Sabina; Kawalec, Magdalena
Introduction. Fibromuscular dysplasia is an idiopathic, non-inflammatory and non-atherosclerotic disease that affects the walls of arteries (mostly renal and carotid arteries). Histological classification distinguishes three main types of the disease, depending on the structural changes occurring in one of the three layers of arterial vessel walls. Objective. We present here a case of fibromuscular dysplasia affecting the internal carotid arteries. Case description. This article describes the case of a 52-year-old female patient with hypertension, hyperlipidemia, and a cardiac pacemaker in whom computed tomography angiography revealed a narrowing of the internal carotid arteries without atherosclerotic symptoms. We describe the diagnostic methods and various types of treatment that the patient suffering from fibromuscular dysplasia was subjected to. Conclusions. Due to a low detection rate of fibromuscular dysplasia, if the disease is suspected, all available diagnostic methods should be employed. Taking into account the unknown etiology of the disease, it is not possible to use a preventive therapy, or a therapy focused on stalling the progression of the disease.
Generation of retractive spine circuits in the process of vitamin B12 deficiency
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Mucha, Patrycja; Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Bartosz, Seweryn; Leksa, Dawid; Bartusik-Aebisher, Dorota
Introduction. Subacute degeneration of the posterior and lateral spinal cord is a rare neurological complication of B12 avitaminosis. Aim. In this paper, we present the case of a 65-year-old man who, in the course of long-term vitamin B12 deficiency associated with atrophic gastritis, developed a severe set of neurological symptoms that are part of the retinal spinal cord degeneration with characteristic features in MR imaging of the cervical spine in the form of an inverted “V mark” ‘in axial images and typical localization in the spinal cord. Description of the case. After careful analysis of the syndrome and making an early diagnosis, parenteral vitamin B12 supplementation began, resulting in improved neurological status, laboratory parameters as well as regression of changes in magnetic resonance imaging. Conclusion Significant symptoms of this syndrome are paresthesia in the distal parts of the limbs, ataxia, spastic paresis.
Glycosaminoglycan concentration in cancer tissue
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bar, Piotr; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
Imaging studies of kidney cancer
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Przyczyna, Piotr; Aebisher, David; Gustalik, Joanna; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Kaznowska, Ewa
Introduction. In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
Infliximab in therapy of inflammatory bowels diseases
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bar, Piotr; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
Infliximab MRI relaxation time in solution
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bober, Zuzanna; Bar, Piotr; Pasternak, Grzegorz; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1) relaxation time and discuss differences where compare to water. Results. The measurements of spin-lattice (T1) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects.
Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Sęk-Mastej, Anna; Galiniak, Sabina; Krawczyk-Marć, Izabela; Balawender, Krzysztof; Szymczak, Artur; Kaniewski, Maciej; Leksa, Natalia; Biesiadecki, Marek; Orkisz, Stanisław
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
Influence of food-derived advanced glycation end products on health
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Galiniak, Sabina; Biesiadecki, Marek
Introduction. Advanced glycation end products (AGEs) are compounds formed endogenously in the human body. Besides this source of AGEs, they also exist in food and can be generated during cooking. Enhanced endogenous generation and intake of dietary AGEs have physiological impact on human health and are associated with progression of many diseases, including diabetes and its complications. Aim. The purpose of this review is to the present the current state of knowledge about the various negative effects of advanced glycation end products on human health. Materials and methods. This study is based on analysis of literature reporting the content of AGEs in food and high or low AGEs dietary interventions in human and animal subjects. Results. Literature data present databases gathering description of AGEs determinations in various types of food. Conclusions. Excessive consumption of AGEs-rich products, especially abundant in protein and fat or cooked for a long time at high temperature, may contribute to the deterioration of human health, including development of hypertension, insulin resistance, and diabetic complications.
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1H Magnetic Resonance Imaging in vitro
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Pogoda, Katarzyna; Pucka, Maria; Tabarkiewicz, Jacek; Bober, Zuzanna; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
Modyfikacje glikacji białek przez stres oksydacyjny i antyoksydanty
(Uniwersytet Rzeszowski, 2016-10-27) Galiniak, Sabina
Glikacja jest nieenzymatycznym procesem łączenia grupy ketonowej lub aldehydowej cukru z wolną grupą aminową białka. W kilkuetapowej i skomplikowanej reakcji ostatecznie dochodzi do powstawania heterogennych końcowych produktów zaawansowanej glikacji, określanych mianem końcowych produktów nieenzymatycznej glikozylacji białek (ang. Advanced Glycation End Products, AGEs). Reaktywne produkty pośrednie reakcji, ulegając licznym modyfikacjom chemicznym, tworzą szereg pochodnych, które przyczyniają się do stresu oksydacyjnego i zmian strukturalnych białek. Glikacja jest związana z generowaniem reaktywnych form tlenu, a wiele AGEs powstaje w reakcjach stanowiących połączenie utleniania i glikacji, które określa się wspólnym mianem glikooksydacji. W niniejszej pracy przedstawiono wyniki badań mających na celu wykazanie czy glikooksydacyjne uszkodzenia białek indukowane przez stres oksydacyjny towarzyszą stwardnieniu rozsianemu (łac. sclerosis multiplex). Ponadto, porównano uszkodzenia białek osocza pacjentów pediatrycznych z mukowiscydozą (zwłóknienie torbielowate, łac. mucoviscidosis) z zakażeniami bakteryjnymi. Dodatkowo, w pracy podjęto próbę wykazania mechanizmu ochronnego działania antyoksydantów poprzez określenie roli wiązania metali w glikacji albuminy.
Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Osuchowski, Michał; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Kaznowska, Ewa
Introduction. The role of multiparametric magnetic resonance imaging (mpMRI) in staging prostate carcinoma has been increasing over the last years. It’s high sensitivity is indispensable when diagnosing this disease. It is a very accurate imaging method that helps the physician choose the best treatment method for his patient. Aim. Assessment of mpMRI which uses both anatomic and functional imaging techniques as a method to diagnose prostatic lesions. Advantages and disadvantages of staging prostate carcinoma with the use of biparametric MRI (bpMRI). Methods. The literature search was performed. Results. MpMRI can be used in pre-operative staging of prostate cancer. The technique is accurate in diagnosing and assessment of prostate carcinoma with Gleason Score (GS) of 7 and above. It is also recommended when planning a second biopsy of the prostatic gland.
Rapidly progressing dementia as a manifestation of the Creutzfeldt-Jakob disease: an analysis of two cases
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bartosz, Seweryn; Leksa, Natalia; Uberman-Kluz, Dominika; Szymczak, Artur; Biesiadecki, Marek; Galiniak, Sabina
Introduction. Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of the central nervous system which is caused by an infectious protein called prion. Multiple forms of CJD have been classified including sporadic (more than 90% cases), familial, iatrogenic and variant type of disease. CJD, especially in its early stages, is a highly challenging illness to diagnose. Aim. Article aims to present cases of Creutzfeldt-Jackob disease with early symptoms of rapidly progressing dementia at the initial stage of CJD. Description of the cases. This paper describes two cases of patients with suspected CJD with a history of rapidly progressive dementia admitted to the Department of Neurology, MSWiA Hospital in Rzeszów. Conclusion. Despite the fact that CJD is an incurable illness and there is no cure guaranteeing recovery, it is important to make the right diagnosis. Assay of 14-3-3 protein in cerebrospinal fluid is a sensitive and specific marker which is helpful in the diagnosis of CJD. The only relevant method of correctly confirming a diagnosis of this disease is by performing a brain biopsy.
Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Biesiadecki, Marek; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Aebisher, David
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary data in the care of a patient suffering from asthma, however analysis of more studies on a larger group of patients is needed.
Stroke masks – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Chmielewska, Beata; Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Leksa, Dawid; Bartosz, Seweryn; Bartusik-Aebisher, Dorota
Introduction. Stroke is a common vascular disease encountered in the work of a practitioner. Despite this, his differentiation is difficult. This is due to a variety of diseases that can be a “mask” for stroke. These are neurological diseases other than vascular (brain tumors, epilepsy), head injuries and a number of metabolic disorders (fluctuations in glucose, electrolytes). Aim. This work aims to approximate the differentiation of this common disease entity. Case reports show both clinical view and diagnostic difficulties. Description of the cases. Case 1. The patient 59 years old treated for bipolar disorder, hypertension and alcohol abuse. Case 2. The patient 68 years old treated for type 2 diabetes, hypertension, ischemic heart disease, cholecystolithiasis – cholecystectomy. Conclusion. Stroke is a significant clinical and social problem both in Poland and in the world. Despite this, its diagnostics and especially differentiation is difficult. When analyzing the case of each patient with suspected sudden CNS vascular disease, all of them should be remembered. It should also be borne in mind that differential diagnosis cannot delay specific treatment for stroke.