Przeglądanie według Autor "Borghi-Silva, Audrey"

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Arterial stiffness can predict cardiorespiratory fitness in type 2 diabetic patients?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022) Monteiro, Clara Italiano; Simões, Rodrigo Polaquini; Heubel, Alessandro Domingues; Silva, Claudio Donisete da; Ricci, Paula Angélica; Petronilho, Ariane; Borghi-Silva, Audrey; Mendes, Renata Gonçalves
Introduction and aim. Arterial stiffness (AS) has been associated with reduced cardiorespiratory fitness (CRF). The aim of this study was to verify if there is a relationship between augmentations index (AIx), as an index for AS assessment, and CRF in individuals with type 2 Diabetes Mellitus (T2DM). Material and methods. Observational cross-sectional study including 32 individuals diagnosed with T2DM who performed two evaluations: 1. Arterial stiffness assessment using SphygmoCor and 2. CRF throughout a cardiopulmonary exercise test on a treadmill ergometer. Oxycon Mobile® device was used to obtain oxygen uptake consumption at peak (V˙ O2peak); oxygen uptake efficiency slope (OUES) determined by linear regression in reason of the logarithmic transformation of the ventilation and V˙ O2 obtained every minute of exercise test. Statistical analysis comprised Pearson’s Correlation and linear regression analysis performed in SigmaPlot. Results. There was a significant correlation between AS and CRF: AIx and OUES; AIx@75 and; OUES. In linear regression, AIx was determinant for V˙ O2peak and OUES – AIx and; AIx@75 and V˙ O2peak. Conclusion. AS was associated with CRF in individuals with T2DM. These results contribute to the body of evidence linking arterial functional properties to CRF and suggests greater attention for this important index.
Circulatory and ventilatory power markers in patients with diabetes mellitus – influence of glycemic control
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2022-12) Menegalli Santos, Letícia; Donisete Da Silva, Claudio ; Lorevice, Laura Beatriz; Italiano Monteiro, Clara ; Ricci, Paula Angélica ; Borghi-Silva, Audrey; Gonçalves Mendes, Renata
Introduction and aim. Cardiorespiratory function has been shown to be impaired in individuals with type 2 diabetes mellitus (T2DM). Some deficiencies in cardiopulmonary exercise test (CPET)-derived variables are known, however, the influence of glycemic control on cardiovascular integrity indices as circulatory power (CP) and ventilatory power (VP), deserve to be instigated. The aim was to investigate the influence of glycemic control on CP and VP indices in T2DM. Material and methods. T2DM individuals of both sexes aged between 40 and 64 years were allocated into two groups: Good glycemic control (GGC, n=11; HbA1c≤7%) and insufficient glycemic control (IGC, n=26; HbA1c>7%). All participants underwent a CPET on a treadmill using a gas analyzer and a laboratory blood test. CP values were obtained by the product of peak of oxygen uptake and systolic blood pressure (SBP) and VP by dividing SBP by the ventilatory efficiency (VE/VCO2 slope). The level of significance was set at p<0.05. Results. No baseline differences were found between the groups, except for the expected fasting glucose and glycated hemoglobin. No differences were found between GGC and IGC groups for CP (4756.05±1061.67 and 4434.15±1247.83 mmHg.ml.kg-1min-1, p=0.460) and VP (5.85±1.08 and 5.86±1.31 mmHg, p=0.978), respectively. Conclusion. CP and VP were similar in individuals with T2DM regardless of glycemic control. Predictive ability of these variables in health outcomes deserves to be further investigated in T2DM.