Przeglądanie według Autor "Bar, Piotr"

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Cytisine parameters measured in the 1.5 Tesla magnetic field
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bober, Zuzanna; Galiniak, Sabina; Leksa, Dawid; Dynarowicz, Klaudia; Aebisher, David; Ostańska, Elżbieta; Czmil, Anna; Bar, Piotr; Bartusik-Aebisher, Dorota; Tutka, Piotr
Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substance.
Glycosaminoglycan concentration in cancer tissue
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bar, Piotr; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
Infliximab in therapy of inflammatory bowels diseases
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bar, Piotr; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
Infliximab MRI relaxation time in solution
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bober, Zuzanna; Bar, Piotr; Pasternak, Grzegorz; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Filip, Rafał; Aebisher, David
Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1) relaxation time and discuss differences where compare to water. Results. The measurements of spin-lattice (T1) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects.
Ocena tkankowego stężenia wybranych leków biologicznych za pomocą magnetycznego rezonansu jądrowego u chorych z wrzodziejącym zapaleniem jelita grubego.
(Uniwersytet Rzeszowski, 2022-03-18) Bar, Piotr
Wrzodziejące zapalenie jelita grubego jest chorobą chroniczną, której diagnoza nie jest łatwa lub wręcz wydaje się niemożliwa we wczesnym stadium. Dlatego podejmowanie prób zastosowania leczenia biologicznego wymaga rozwoju diagnostyki do monitorowania stadium choroby. W pracy badano i analizowano materiał tkankowy wrzodziejącego zapalenia jelita grubego od chorych i poddano go badaniu magnetycznemu rezonansowi jądrowemu in vitro. Wykorzystując różne czasy relaksacji w tkance zdrowej i chorej można określić stężenia badanych leków biologicznych w surowicy krwi oraz w pobranych wycinkach z jelita grubego. Praca dotyczy oceny stężeń leku biologicznego za pomocą MRI. Pomiary tkanek in vitro pozwolą na podjęcie próby odpowiedzi, dlaczego u części chorych odpowiedź na leczenie jest dobra, a u innych nieskuteczna. Pacjentów zakwalifikowano do leczenia biologicznego oraz prowadzenia dalszego badania, celem bliższego poznania różnic w mechanizmach immunologicznych zachodzących u pacjentów. W pracy omówiono rolę i zakres działania leków biologicznych. Dokonano przeglądu wskazań klinicznych dotyczących leczenia WZJG. Wskazano nowoczesne wykorzystanie rezonansu jądrowego polegające na obrazowaniu przyjelitowym i pomiar parametrów relaksacji.
Parathyroid adenoma in a 15-year-old girl with recurrent urolithiasis
(Publishing Office of the University of Rzeszow, 2023-06) Kucaba, Patrycja; Dziadzio-Gąsior, Katarzyna; Podlasek, Robert; Bar, Piotr; Korczowski, Bartosz
Introduction and aim. The incidence of urolithiasis in children has been growing steadily for several decades, and it accounts for an increasing percentage of hospitalizations. Kidney stones are deposits of various mineral salts. Most of them are composed of calcium, favored by hypercalcemia and hypercalciuria. Primary hyperparathyroidism is one of the reasons for increased calcium levels in the blood. Description of the case. A 15-year-old girl was hospitalized due to recurrent urolithiasis. Investigations revealed hypercalcemia with elevated parathyroid hormone. Ultrasound of the thyroid gland showed a local change near the lower pole of its right lobe, and Sestamibi nuclear scan confirmed the presence of the adenoma of the lower right parathyroid gland. Surgical removal of the parathyroid gland with the present adenoma was performed. Calcium and phosphate homeostasis parameters and the kidneys’ ultrasound image were without any significant deviations from the norm. Conclusion. After finding the cause of recurrent urolithiasis, the applied surgical treatment resolved all disease manifestations.