European Journal of Clinical and Experimental Medicine T.18, z. 1 (2020)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/5770

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Przeglądanie European Journal of Clinical and Experimental Medicine T.18, z. 1 (2020) według Autor "Galiniak, Sabina"

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  • Obrazek miniatury
    Pozycja
    Cytisine parameters measured in the 1.5 Tesla magnetic field
    (Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bober, Zuzanna; Galiniak, Sabina; Leksa, Dawid; Dynarowicz, Klaudia; Aebisher, David; Ostańska, Elżbieta; Czmil, Anna; Bar, Piotr; Bartusik-Aebisher, Dorota; Tutka, Piotr
    Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substance.
  • Obrazek miniatury
    Pozycja
    Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1H Magnetic Resonance Imaging in vitro
    (Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Pogoda, Katarzyna; Pucka, Maria; Tabarkiewicz, Jacek; Bober, Zuzanna; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota
    Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
  • Obrazek miniatury
    Pozycja
    The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine
    (Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Pękala, Anna; Pardak, Piotr; Dziedzic, Rafał; Bartusik-Aebisher, Dorota; Filip, Rafał; Galiniak, Sabina; Aebisher, David
    Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.