European Journal of Clinical and Experimental Medicine T.18, z. 1 (2020)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/5770

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Effects of sensory integration therapy in a 7-year old child with epilepsy following craniocerebral trauma – a case study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Widelak, Maria; Wolan-Nieroda, Andżelina; Podgórska-Bednarz, Justyna; Guzik, Agnieszka
Introduction. Post-traumatic epilepsy develops as a complication of a serious craniocerebral trauma, frequently an open head injury, resulting in neurological impairments. Aim. The study was designed to discuss problems associated with sensory integration dysfunction observed in a seven-year old girl with epilepsy which occurred as a result of craniocerebral injury. Description of the case. The case study is based on information gained from the girl’s medical records, an interview with her guardians and a sensory function questionnaire. Additional examinations assessed the girl’s balance control, and her functional performance according to Barthel scale. The girl received a three-week sensory integration therapy which included exercise involving tactile, vestibular and proprioceptive stimulation, as well as balance exercises and self-care training. Conclusions. In this particular case, application of sensory integration therapy produced beneficial results. The findings show improvement in balance, coordination as well as self-care.
External ophthalmomyiasis by sheep botfly – a report from Sirmaur hills
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Chauhan, Anubhav; Gautam, Neha
Introduction. Myiasis is caused by larvae of flies infesting animal or human tissues and organs. Aim. In this report we present 2 cases of external ophthalmomyiasis by sheep botfly. Description of the cases. We report a case of two patients who presented with a history of foreign body sensation in the left and the right eye respectively. Slit lamp examination revealed larvae of Oestrus ovis (sheep botfly). In both cases, there was no contact history with sheep or goats. Signs of conjunctival inflammation and corneal involvement were absent in both cases. In most of the previous reports, corneal and conjunctival inflammation was present. Conclusion. Treatment for external ophthalmomyiasis is based on larvae removal and application of topical antibiotics and steroids.
Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bargotya, Mona; Mehta, Ankita; Das, Payel; Sachan, Ashish
Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas. It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.
Parotid pilomatrixoma: Diagnostic trap and management dilemma
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bhardwaj, Abhishek; Angral, Sumeet; Chandra, Sharath; Malhotra, Manu; Priya, Madhu; Varshney, Saurabh; Singh, Arpana; Raj, Ritu
Introduction. Pilomatrixoma is a benign cutaneous adnexal neoplasm originating from the matrix cells of the hair follicles. Usually a slow growing and painless lesion, it must be considered in differential diagnosis of a preauricular swelling. Rapidly progressive lesion with skin fixity and missed subtle cytological features may lead to a misdiagnosis of parotid neoplasm resulting in management dilemma. Aim. This report emphasizes consideration of pilomatrixoma as a differential diagnosis in a similar clinical scenario, the role of frozen section during surgery and fascia lata interposition to prevent Frey’s syndrome. A brief review of literature is presented. Description of the case. We present a similar dilemmatic case of a 19 years old male with preauricular swelling. Based on cytology and image findings, a diagnosis of parotid neoplasm with possible malignancy was made. Surgical exploration revealed primarily a subcutaneous lesion with partial attachment to superficial surface of parotid. Lesion was excised with a cuff of normal parotid tissue. Frozen section confirmed it to be a nonmalignant lesion with possibility of pilomatrixoma. Fascia lata was interposed between parotid and thin skin flap to avoid gustatory sweating. Patient is on follow up for 6 months without recurrence or any complication. Conclusion. Pilomatrixomas can be misdiagnosed in case of lesions in subcutaneous plane in parotid region. In such cases, the differential diagnosis should include tumor and non-tumor lesions of skin and parotid gland. Importance of frozen section should also be kept in mind and the pathologist should be engaged at the time of surgical excision of the tumor. Interposition of soft tissue between parotid and thin skin flap helps prevent gustatory sweating in such cases. A high index of suspicion is needed for proper diagnosis and management of these lesions.
Atypical extra nasopharyngeal angiofibroma in an unusual location: tonsil posterior pillar (oropharynx)
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Mittal, Shweta; Priya, Madhu; Varshney, Saurabh; Angral, Sumeet; Xavier, Joyson; Malhotra, Manu; Bhardwaj, Abhishek; Kumar, Amit; Tyagi, Amit Kumar
Introduction. Angiofibroma is a benign, locally aggressive highly vascular tumor that typically affects young adolescent males and has a pathognomonic epicenter of origin in the nasopharynx. The atypical angiofibromas share the same histological features as that of Juvenile nasopharyngeal angiofibroma, however they differ significantly in their clinical features. Aim. Here we are reporting a very rare case of atypical angiofibroma in an adult male presenting as a non-vascular mass in the oropharynx with posterior pillar as the subsite. Description of the case. A 26-years old male patient presented with chief complaints of foreign body sensation and mass in throat for one and a half months which was gradually progressive in size. Histopathological examination revealed a lesion with an intricate mixture of blood vessels, irregular fibrous stroma with loose edematous and fibrous area along with multinucleated stromal cells which was suggestive of angiofibroma. Conclusion. Oropharyngeal angiofibroma, being an atypical angiofibroma in terms of site and presenting complaints, presents a diagnostic challenge. Though rare, it should always be kept as a differential diagnosis in any oropharyngeal mass irrespective of its vascularity, typical age or sex of the patient.
Splenic hydatidosis with abdominal pain – a rare presentation in a developing nation
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Akhtar, Kafil; Alam, Saquib; Rab, Atia Zaka-ur; Sherwani, Rana K
Introduction. Primary extrahepatic hydatid cysts are rare, and primary splenic hydatid cysts even rarer. Splenic hydatidosis constitutes 2% to 3.5% of all hydatid cysts. Aim. To present a case report of splenic hydatidosis with abdominal pain. Description of the case. We report here a case of isolated splenic hydatid cysts in a 23 year old female, who presented with dull dragging pain in the left hypochondrium. Diagnosis was made on computed tomography imaging of the abdomen and microscopic examination of the laminated hydatid cyst wall and supplemented with positive enzyme linked immunosorbent assay for hydatid antibodies. Conclusion. The incidence of splenic involvement by hydatid cysts is very low. Man is an accidental intermediate host, as entry of the larval forms into humans represents an end stage in its life cycle. Until recently the gold standard treatment for splenic hydatidosis was splenectomy, as medical therapy seems to be ineffective. However, the last two decades have shown a tendency towards splenic conservative surgery in suitable cases, to reduce opportunistic post splenectomy infection.
Rare Benign cystic teratoma in the parotid gland
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Gharaibeh, Mahmoud M.; Wadiya, Ahmed Al; Gharaibeh, Ahmad; Hammad, Hdua
Introduction. A teratoma is a tumor developed of several different types of tissue, like hair, muscle, teeth or bone. Aim. Mature benign cystic teratomas are very rare in the salivary glands and just few cases were reported. Description of the case. A 13 years old female was presented to our dental clinic of Princes Basma Hospital in Irbid in north of Jordan, with a painless, insidious progressive swelling in left parotid region without any significant family and personal history. Parents were cancer phobic and nervous from the condition of their daughter, they were very confused. There was no pain or any history of trauma. It was present just inferior to left ear cartilage. The mass was of size 3x3cm, non-tender, fixed, soft to firm in consistency, having smooth surface. Conclusion. Teratoma in parotid region is an extremely rare entity. Lack of any pathognomonic feature, it is hard to diagnose preoperatively. Lumpectomy is advisable to remove the mass because the risk of damaging facial nerve in young patients and recurrence is rare. A definitive diagnosis is achieved after the histopathological study. Teratoma should be kept in account while evaluating a case of a soft tissue mass of parotid gland as a differential diagnosis.
Treating kidney cancer – a review
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Przyczyna, Piotr; Aebisher, David; Bartusik-Aebisher, Dorota; Kaznowska, Ewa
Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
Glycosylation of immune system proteins and its role in autoimmune diseases and cancer
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Trzyna, Anna; Tabarkiewicz, Jacek; Mazur, Artur
Introduction. Structural glycans have great biological significance and are involved in signaling and cell communication of the immune system. They are attached to proteins and lipids in an enzymatic process called glycosylation where glycosyltransferase and glycosidases bind sugar residues and lead to the formation of bioconjugates. Aim. In this paper we describe the importance of glycosylation in the immune system and its changes in diseases. Material and methods. This review was performed according to systematic literature search of major bibliographic databases. Results. Proper glycosylation ensures the functioning of the organism, however, defects in structural glycans of immune system changes their properties and can lead to disorders and further to autoimmune diseases. It has been also proven that glycosylation of autoimmune system is changed during cancer. In this paper we described types of structural glycans, significance of glycosylation of selected components of the immune system and its modifications in disorders. Conclusions. Knowledge about changes in the glycosylation in diseases is the key to understanding the processes of autoimmune diseases and may allow the development of new treatments in the future.
The role of MRI in the central nervous system
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Aebisher, David; Bartusik-Aebisher, Dorota
Introduction. Magnetic Resonance Imaging (MRI) has modified the practice of radiology. MRI is base on safe interaction between radiowaves at a particular frequency and hydrogen nuclei in the body. Metabolic encephalophaties are by definition those disorder of the central nervous system that are not due primarily to structural abnormalities. Aim. Here we present the 1H MRI and functional MRI (fMRI) method applied to diagnosis of disorders of the central nervous system. Material and methods. Analysis of literature and self-research. Results.We have discussed the major MRI applications in the characteristic of the central nervous system. The relationship beteen the motion of flowing blood and the representation of the blood on images is complex. This work is an introduction to the basic ideas and techniques of fMRI. Therefore, both, 1H MRI and functional MRI, methods are ued in neuroscience. Conclusion. Nonivasive MRI and functional MRI are daily diagnostics methods in neurology.
Radio Frequency MRI coils
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Truszkiewicz, Adrian; Aebisher, David; Bober, Zuzanna; Ożóg, Łukasz; Bartusik-Aebisher, Dorota
Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.
The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Pękala, Anna; Pardak, Piotr; Dziedzic, Rafał; Bartusik-Aebisher, Dorota; Filip, Rafał; Galiniak, Sabina; Aebisher, David
Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
Cytisine parameters measured in the 1.5 Tesla magnetic field
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Bober, Zuzanna; Galiniak, Sabina; Leksa, Dawid; Dynarowicz, Klaudia; Aebisher, David; Ostańska, Elżbieta; Czmil, Anna; Bar, Piotr; Bartusik-Aebisher, Dorota; Tutka, Piotr
Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substance.
Depressive symptoms during pregnancy and their risk factors – a cross-sectional study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Feduniw, Stepan; Płaza, Olga; Paździor, Dominika; Kosińska-Kaczyńska, Katarzyna; Szymusik, Iwona; Wielgoś, Mirosław
Introduction. It was established that intragestational depression is a common disease, with the estimated average prevalence of 10–25% in all expectant mothers worldwide. Aim of the study. The aim of the study was to evaluate the frequency of depressive symptoms in pregnant women in Poland and to identify which factors may be related to a higher risk of depressive symptoms during pregnancy. Material and methods. A prospective cross-sectional study was performed. Depressive symptoms were assessed with the validated Edinburgh Postnatal Depression Scale (EPDS). 346 women were enrolled in the study. Results. 130 women (37.6%) scored 13 or more points and were considered as presenting with depressive symptoms. Independent risk factors of depressive symptoms during pregnancy including mood disorders diagnosed before the current pregnancy (aOR=2.68, 95%CI 1.37-5.22), mental disorders confirmed in family members (aOR=2.72, 95%CI 1.24-5.98), unhappiness in their current relationship (aOR=4.0, 95%CI 1.77-9.01), lack of support from family members (aOR=2.73, 95%CI 1.51-4.96) increased the risk of DS and good financial status decreased the risk of DS occurrence (aOR=0.45, 95%CI: 0.25-0.80). Conclusions. Pregnant women commonly report depressive symptoms. The evaluation of relations with the family members, socio-economic status, former depressive symptoms and possible prenatal depression are essential for proper screening of depression in pregnant women.
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1H Magnetic Resonance Imaging in vitro
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Pogoda, Katarzyna; Pucka, Maria; Tabarkiewicz, Jacek; Bober, Zuzanna; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.

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