The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine

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dc.contributor.authorLeksa, Natalia
dc.contributor.authorPękala, Anna
dc.contributor.authorPardak, Piotr
dc.contributor.authorDziedzic, Rafał
dc.contributor.authorBartusik-Aebisher, Dorota
dc.contributor.authorFilip, Rafał
dc.contributor.authorGaliniak, Sabina
dc.contributor.authorAebisher, David
dc.date.accessioned2020-11-16T10:33:04Z
dc.date.available2020-11-16T10:33:04Z
dc.date.issued2020
dc.description.abstractIntroduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 18, z. 1 (2020), s. 20–23pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2020.1.4
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/5775
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject13C NMRpl_PL.UTF-8
dc.subjectdynamic nuclear polarizationpl_PL.UTF-8
dc.subjecthyperpolarized carbonpl_PL.UTF-8
dc.titleThe potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alaninepl_PL.UTF-8
dc.typereviewpl_PL.UTF-8
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European Journal of Clinical and Experimental Medicine T.18, z. 1 (2020)