Evaluation of oxidative stress level and glutathione system in patients with psoriasis in Basrah Governorate, Iraq

Abstract

Introduction and aim. Psoriasis is a persistent chronic disease with no known cause or cure. This study aimed to estimate oxi dative stress and glutathione systems, and their association with factors (age, gender, disease severity, and geographical location) in psoriasis patients. Material and methods. The study was carried out in the Al-Fayhaa and the Basrah Teaching Hospitals. The number of patients was 45 with 45 in the control group. We quantified the amounts of malondialdehyde (MDA), protein carbonyl (PC), 8-hydrox yguanosine, glutathione, glutathione reductase (GR), glutathione peroxidase (GPx), and selenium. Results. The results showed significant differences in all variables at multiple statistical levels (p<0.05, p<0.01, p<0.001). The study found significant differences between two groups within the allowed concentration range. Some inter-factor fluctuations were found, and these fluctuations were noticeable in age and sex, and not significant in disease severity or location. The pa tients did not experience oxidative stress due to the oxidation of lipids and proteins, but rather DNA oxidation. Conclusion. Lipid peroxidation or protein oxidation do not correlate with psoriasis. While a marker for DNA oxidation exists, it yields different results in psoriasis patients compared to healthy individuals. We observed a correlation between MDA, GR and PC, GPx, PC, and selenium, which serves as the cofactor of the GPx enzyme.