Pathogenesis of selected multiple primary neoplasms

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dc.contributor.authorWitek, Marcin Kazimierz
dc.contributor.authorSkrzynecka, Sabina
dc.contributor.authorBartoszek, Mateusz
dc.contributor.authorMichalik, Julia
dc.contributor.authorPudźwa, Jakub
dc.date.accessioned2023-09-29T11:43:55Z
dc.date.available2023-09-29T11:43:55Z
dc.date.issued2023-09
dc.description.abstractIntroduction and aim. Multiple primary tumors are defined as having more than one primary tumor in a different organ location in the same person. Therefore, it is important to know pathogenesis of multiple primary neoplasms to discover new forms of primary prevention and secondary prevention, especially connected with genetic tests which are important for the future of medicine as a part of personalized medicine. The aim of the study is to present selected aspects of the pathogenesis of multiple primary neoplasms. Material and methods. PubMed databases and Google Scholar were searched. Analysis of the literature. The rising risk of developing multiple primary cancers is a consequence of the progressive growth and ageing of the population and development of cancer in patients previously treated for cancer. The formation of secondary neoplasms may be multifactorial – to a large extent it is associated with genetic factors that may facilitate neoplastic transformation, for example as a result of radiation therapy, chemotherapy, inherited syndromes, environmental factors such as tobacco or alcohol, sometimes random somatic mutations. Conclusion. Knowledge of the pathogenesis of multiple primary tumors can contribute to a better understanding of the problem, as well as help in the prevention or early diagnosis of multiple primary tumors (primary and secondary prevention).eng
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 21, z. 3 (2023), s. 605-616
dc.identifier.doi10.15584/ejcem.2023.3.6
dc.identifier.eissn2544-1361
dc.identifier.urihttps://repozytorium.ur.edu.pl/handle/item/9340
dc.language.isoeng
dc.publisherPublishing Office of the University of Rzeszow
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Poland*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectpathogenesis
dc.subjectmultiple primary neoplasms
dc.subjectmultiple primary tumors
dc.subjectoncogenetics
dc.subjectpersonalized medicine
dc.subjecttumor biology
dc.titlePathogenesis of selected multiple primary neoplasms
dc.typearticle
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European Journal of Clinical and Experimental Medicine T.21, z. 3 (2023)