The influence of oxalate decarboxylase on the urinary oxalate excretion in swine model of nephrocalcinosis induced by hydroxyproline

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dc.contributor.authorPierzynowska, Kateryna
dc.contributor.authorPierzynowski, Stefan Grzegorz
dc.contributor.authorLozinska, Liudamyla
dc.contributor.authorJarmakiewicz, Sara
dc.contributor.authorŚwieboda, Paulina
dc.contributor.authorFedkiv, Olexandr
dc.contributor.authorSzwiec, Katarzyna
dc.contributor.authorValverde Piedra, Jose Louis
dc.contributor.authorFilip, Rafał
dc.date.accessioned2018-04-04T11:46:09Z
dc.date.available2018-04-04T11:46:09Z
dc.date.issued2017
dc.description.abstractIntroduction. Kidney stone formation may be a result of increased urinary oxalate supersaturation. Material and Methods. Eighteen pigs were randomly divided into: Control group, where standard cereal-based feed was supplemented with 4% HP only, Prevention group, where treatment with OxDc slurry started at the end of the adaptation period when pigs were switched to 4% HP diet, Reduction group, where the treatment with OxDc lyo powder started after pigs were already on a 4% HP diet for 6 days. Results. OxDc slurry prevented oxalate excretion in urine. The reduction effect of OxDc lyo feed addition was generally visible during the first two days of the therapy (p<0.05). Both dietary intake of 4% HP and OxDc preparations did not influence weight gain, water or feed intake, urine excretion and creatinine clearance. Conclusions. The capacity of OxDc in preventing induced hyperoxaluria was moderate. Most probably, this is due to the incoherent response of animals to the HP enriched diet dependent on their gut pH, since optimum pH for OxDc is around 5-6. A higher pH essentially reduces the activity of OxDc. The capacity of OxDc in reversing the hyperoxaluria induced by a HP enriched diet was significant during the first 2 days after introducing OxDc to the diet.pl_PL.UTF-8
dc.identifier.citationEuropean Journal of Clinical and Experimental Medicine T. 15, z. 3 (2017), s. 206–216pl_PL.UTF-8
dc.identifier.doi10.15584/ejcem.2017.3.4
dc.identifier.eissn2544-1361
dc.identifier.issn2544-2406
dc.identifier.urihttp://repozytorium.ur.edu.pl/handle/item/3497
dc.language.isoengpl_PL.UTF-8
dc.publisherWydawnictwo Uniwersytetu Rzeszowskiegopl_PL.UTF-8
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNephrocalcinosispl_PL.UTF-8
dc.subjectOxalate decarboxylasepl_PL.UTF-8
dc.subjectHydroxyprolinepl_PL.UTF-8
dc.subjectPig modelpl_PL.UTF-8
dc.titleThe influence of oxalate decarboxylase on the urinary oxalate excretion in swine model of nephrocalcinosis induced by hydroxyprolinepl_PL.UTF-8
dc.typearticlepl_PL.UTF-8
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European Journal of Clinical and Experimental Medicine T.15, z. 3 (2017)