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Clinical aspects of protein glycation

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Show simple item record Galiniak, Sabina Krawczyk-Marć, Izabela Sęk-Mastej, Anna Leksa, Natalia Biesiadecki, Marek Orkisz, Stanisław 2018-04-04T12:53:29Z 2018-04-04T12:53:29Z 2017
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 15, z. 3 (2017), s. 263–267 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.description.abstract Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe *
dc.rights.uri *
dc.subject AGEs pl_PL.UTF-8
dc.subject glycation pl_PL.UTF-8
dc.subject advanced glycation end products pl_PL.UTF-8
dc.subject multiple sclerosis pl_PL.UTF-8
dc.title Clinical aspects of protein glycation pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2017.3.10
dc.identifier.eissn 2544-1361

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