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Model development of hydroxyproline induced hyperoxaluria in young growing pigs

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dc.contributor.author Goncharova, Kateryna
dc.contributor.author Filip, Rafał
dc.contributor.author Świeboda, Paulina
dc.contributor.author Prykhodko, Olena
dc.contributor.author Fedkiv, Olexandr
dc.contributor.author Szwiec, Katarzyna
dc.contributor.author Valverde Piedra, Jose Luis
dc.contributor.author Majda, Blanka
dc.contributor.author Pierzynowski, Stefan Grzegorz
dc.date.accessioned 2017-07-13T12:18:55Z
dc.date.available 2017-07-13T12:18:55Z
dc.date.issued 2017
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 15, z. 1 (2017), s. 6–11 pl_PL.UTF-8
dc.identifier.issn 2544-1361
dc.identifier.uri http://repozytorium.ur.edu.pl/handle/item/2800
dc.description.abstract Aim of the study. In this study, we sought to create a model of reversible hyperoxaluria in pigs by feeding with hydroxyproline (HP). Materials and methods. The experiment included 12 pigs divided into 2 groups (n = 6). The pigs were fed twice a day. At the beginning of the experiment, in the adaptation period, all pigs were given standard feed. In the next 7 days, an increasing amount of hydroxyproline (1–3% HP), was added to the feed. In next 14 days, 4% HP was administered in each pig meal. After 14 days of 4% HP diet, the pigs were randomly divided into 2 groups. For 6 pigs, 4% HP treatment had been continued for the next 14 days while the second group of pigs for the next 14 days received a standard HP free diet. 24h urine samples, blood and fecal samples were collected on particular days. Results. The addition of HP to the diet increased urinary oxalate excretion. A characteristic increase was noted after 12 days of treatment with 4% HP. During the removal period, oxalate excretion decreased in the group without HP in diet, while in the group which continued with a 4% HP diet, oxalate excretion significantly increased. Gross examination of kidneys showed that in the group which had 4% HP diet for 4 weeks, kidneys were fibrotic with enlarged cavities, and had small visible urinary stones. In second group, kidneys were relatively normal looking with no visible stones. Conclusion. Hyperoxaluria is reversible, if HP is removed 14 days after the start of 4% HP diet. Prolonged exposure up to 4 weeks causes pathologic changes in kidneys including crystals, sand and small stone formation. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/ *
dc.subject pig model pl_PL.UTF-8
dc.subject hyperoxaluria pl_PL.UTF-8
dc.subject kidney stones pl_PL.UTF-8
dc.subject hydroxyproline pl_PL.UTF-8
dc.title Model development of hydroxyproline induced hyperoxaluria in young growing pigs pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2017.1.1


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Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska

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