Przeglądanie według Temat "singlet oxygen"

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Chemiluminescence-driven Dye Excitation for Dark Photodynamic Therapy
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2017) Ożóg, Łukasz; Tabarkiewicz, Jacek; Aebisher, David
Photodynamic therapy is a treatment that uses a combination of light-absorbing photosensitizers and dissolved oxygen to kill cancer. One specific limitation of photodynamic therapy is that the visible light used for photosensitizer excitation has a short tissue penetration depth of several millimeters. This limits the application of photodynamic therapy to surface cancers in the absence of a technique to illuminate deeper tissue. Efforts to extend tissue depth to which photodynamic therapy can be applied have been attempted with use of up-conversion and persistent-luminescent nanoparticles that absorb near infrared light and emit visible light for photosensitizer excitation, yet an initial excitation with an external light source is still required. More recently, systems employing chemiluminescence as an excitation energy source designed to bypass the use of external light have been developed and investigated as potential agents that could overcome the problem of achieving photodynamic therapy in deep tissue. We wish to provide an overview of several systems that have been recently reported that employ both radiative and non-radiative chemiluminescent energy transfer for photosensitizer excitation that have been developed in the hope of achieving “dark” photodynamic therapy. This article reviews several of these important new developments in the design of photodynamic therapeutic systems that utilize chemiluminescence.
Singlet oxygen discovery
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Ciesielka, Anna
Introduction. Singlet oxygen is perfectly suited to interact with biological macromolecules and cellular composition. Aim. The goal was to present an information about singlet oxygen discovery. Material and methods. In this article a narrative review regarding singlet oxygen discovery. Analysis of the literature. The desire to summarize information about generation and basic application of singlet oxygen is presented. Conclusion. The history of singlet oxygen is well documented in literature.
Singlet oxygen lifetime and diffusion measurements
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Ożóg, Łukasz; Aebisher, David
Introduction. Photodynamic therapy (PDT) is considered to be a promising antitumor methodology due the cytotoxicity of singlet oxygen (1O2). Aim. To present singlet oxygen which is highly reactive and decomposes to the ground state rapidly. Material and methods. Analysis of literature. Results. This review presents techniques to measure lifetime and diffusion of 1O2.