Przeglądanie według Temat "interleukin"

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A study of several hematological and immunological parameters of patients with rheumatoid arthritis and their relationship with type 2 diabetes mellitus
(Rzeszów University Press, 2025-06) Abed, Gadder Osama; Ali, Baida Rihan
Introduction and aim. Rheumatoid arthritis (RA) is a systemic inflammation that damages the joints and causes disability. In RA, glucocorticoids reduce inflammation and peripheral insulin resistance. This study aimed to investigate hematological and immunological parameters, including interleukin-24 (IL-24), interleukin-32 (IL-32), and rheumatoid factor (RF), in patients with RA, type 2 diabetes mellitus, or both, and to assess their interrelationships. Material and methods. A case-control study on RA and type 2 diabetes mellitus was conducted at Al-Nasiriyah Education Hospital with 100 blood samples collected from patients, divided into four groups. Complete blood counts (CBC), erythrocyte sedimentation rate (ESR), RF, IL-24, and IL-32 levels were measured using automated analyzers and enzyme-linked immunosorbent assay. Results. Patients with both diseases showed elevated ESR (p<0.001) and RF (p<0.01). RA patients increased significantly in ESR and RF, but there was no statistically significant difference in RF in type 2 diabetic patients. IL-24 was not statistically significantly increased in RA patients. IL-32 levels increased significantly in type 2 diabetes (p=0.02), while RA showed no significant difference. Conclusion. Patients with RA have elevated levels of IL-32 expression and has a positive correlation with indicators of RA activity indicators such as ESR and RF. An increase in IL-24 and IL-32 in RA patients indicates a positive correlation between IL-24 and IL-32. Diabetic patients exhibit significantly elevated pro-inflammatory properties of IL-32.
Clinical significance of serum interleukin-6 levels in patients with chronic kidney disease
(Publishing Office of the University of Rzeszow, 2024-09) Chokkavarapu, Renuka Charan; Bachireddy, Parimala; Billa, Vaibhavi Reddy; Vityala, Yethindra
Introduction and aim. Elevated levels of interleukin-6 (IL-6) in serum and kidney tissues are associated with the development and progression of chronic kidney disease (CKD). Although the role of pro-inflammatory cytokines, such as IL-6, in the development of cardiovascular complications is well studied, the relationship between serum IL-6 levels and CKD markers remains unclear. This study investigated the clinical significance of serum IL-6 levels in patients with CKD. Material and methods. Participants were divided into two groups based on estimated glomerular filtration rate (eGFR): group 1 (n=86) with eGFR >60 mL/min and group 2 (n=74) with eGFR <60 mL/min. The CKD Epidemiology Collaboration equation was used to calculate eGFR from serum creatinine and cystatin C levels to assess CKD severity. Results. Systolic blood pressure was higher in Group 2 than in Group 1 (138±22 mmHg vs. 129±19 mmHg; p<0.05). Serum IL-6 levels were also higher in group 2 (3.095 [interquartile range: 1.528–6.547] pg/mL) than in group 1 (1.711 [interquartile range: 0.920– 3.342] pg/mL; p <0.05). Serum IL-6 levels were strongly correlated with eGFR in multivariable-adjusted linear regression analysis. Conclusion. IL-6 levels increased in patients with CKD with an eGFR <60 mL/min, and this increase was associated with eGFR and diastolic blood pressure.