Przeglądanie według Temat "epilepsy"

Aktualnie wyświetlane 1 - 3 z 3

Effects of sensory integration therapy in a 7-year old child with epilepsy following craniocerebral trauma – a case study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Widelak, Maria; Wolan-Nieroda, Andżelina; Podgórska-Bednarz, Justyna; Guzik, Agnieszka
Introduction. Post-traumatic epilepsy develops as a complication of a serious craniocerebral trauma, frequently an open head injury, resulting in neurological impairments. Aim. The study was designed to discuss problems associated with sensory integration dysfunction observed in a seven-year old girl with epilepsy which occurred as a result of craniocerebral injury. Description of the case. The case study is based on information gained from the girl’s medical records, an interview with her guardians and a sensory function questionnaire. Additional examinations assessed the girl’s balance control, and her functional performance according to Barthel scale. The girl received a three-week sensory integration therapy which included exercise involving tactile, vestibular and proprioceptive stimulation, as well as balance exercises and self-care training. Conclusions. In this particular case, application of sensory integration therapy produced beneficial results. The findings show improvement in balance, coordination as well as self-care.
Impact of caloric restriction on the Wnt/β-catenin pathway in the hippocampus and cortex of a Kindled rat model
(Rzeszów University Press, 2025-03) Uribe, Eric; López-Landa, Alejandro; Serrano-García, Norma; Ochoa, Ernesto; Marin-Castañeda, Luis A.; Vázquez, David; Orozco, Sandra; Romo-Parra, Héctor; Gonzalez-Garibay, Guillermo; Rubio-Osornio, Moisés; Rubio, Carmen
Introduction and aim. Epilepsy is a common neurological disorder, and despite numerous treatment options, approximately 30% of patients have drug-resistant epilepsy. This situation prompts the exploration of alternative treatments such as caloric restriction (CR), whose mechanisms of antiepileptic action need to be fully elucidated. One of the key overactivated pathways in epilepsy is the Wnt/β-catenin pathway. Material and methods. To explore the potential regulatory effects of CR on this pathway, we conducted a study using twen ty-eight male Wistar rats divided into four groups (7 animals each): Control, Sham (20% CR), kindling ad libitum (KAL), and kindling with CR (KCR). Caloric restriction rats received 80% of their daily food intake based on body weight, compared to those fed ad libitum. The kindling model was achieved by the introduction of an electrode in the basolateral nucleus of the amygda la. Immunofluorescence and Western blot techniques were used for the analysis of protein levels (Wnt, β-catenin, GSK3β, and cyclin D) in the frontal cortex and hippocampus. Results. Electroencephalographically and behaviorally, the KCR group exhibited a shorter duration of seizures and an increased behavioral threshold compared to the KAL group. Protein analysis revealed an increase in Wnt pathway proteins (Wnt, β-catenin, and cyclin D) in the KAL group compared to the control group. In contrast, CR reduced protein levels in animals that were induced to kindling. Conclusion. These findings suggest that CR may exert its antiepileptic effects through the regulation of the Wnt pathway by inhibiting its activity in the hippocampus and cortex of kindled rats.
Paroxysmal non-epileptic events vs epilepsy – what we know and where we are in medicine?
(Publishing Office of the University of Rzeszow, 2024-03) Syzdoł, Bartłomiej; Ziółkiewicz, Aleksandra; Sielwanowska, Wiktoria; Żybowska, Monika; Wilczek, Natalia; Szukała,Klaudia; Chrościńska-Krawczyk, Magdalena
Introduction and aim. Paroxysmal non-epileptic events (PNEEs) are neurological conditions that include behavioral changes or disturbances of consciousness. The aim of the article is to compare individual paroxysmal non-epileptic events disorders, to indicate differences in their clinical picture and to discuss their differential diagnosis. Material and methods. A review of the most common non-epileptic paroxysmal events is presented based on the available literature of PubMed and Google Scholar databases from 2000 to 2023. Analysis of the literature. Depending on the age of the child, the nature and type of seizures are variable. Unfortunately, epilepsy is currently overdiagnosed, which results in the inclusion of antiepileptic drugs without the need to use them. This may be related to the immaturity of the central nervous system, malfunctioning of other organs or have a psychogenic background. In most cases, they do not require pharmacological treatment. Conclusion. Paroxysmal non-epileptic events, due to the diverse and uncharacteristic clinical picture, pose a major diagnostic challenge. Because of the current overdiagnosis of epilepsy they should always bear in mind differential diagnosis. This is important because of the differences in the treatment of these disorders.