Przeglądanie według Autor "Voloshyn, Olena R."

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Neuroendocrine and metabolic predictors of the effects of balneotherapy at the Truskavets Spa on physical working capacity in men with maladaptation
(Rzeszów University Press, 2025-03) Popovych, Igor L.; Zukow, Walery; Melnyk, Oksana I.; Fil, Vitalii M.; Kovalchuk, Halyna Y.; Bryndzia, Iryna V.; Voloshyn, Olena R.; Kopko, Iryna Y.; Lupak, Oksana M.; Skrobach, Taras B.; Kravtsiv, Mariana М.; Musiyenko, Olena V.; Popovych, Dariya V. Popovych
Introduction and aim. The effect of balneotherapy in the Truskavets Spa on physical working capacity is complex and individ ualized. This study aims to identify an optimal constellation of predictors for the actotropic effects of balneotherapy. Material and methods. We observed 34 men with maladaptation against the background of chronic pyelonephritis in remis sion. We recorded physical working capacity, heart rate variability, electroencephalography, adaptation hormones, and blood and urine metabolites before and after a standardized balneotherapy regimen. Results. Standard balneotherapy resulted in various effects on physical working capacity150 : an increase in 9 patients (26.5%), no significant change in 16 patients (47.1%), and a decrease in 9 patients (26.5%). Through discriminant analysis, we identified a constellation of 25 initial parameters that could predict the nature of the actotropic effect with 100% accuracy. These parameters included measures of physical working capacity, cardiorespiratory fitness, electroencephalography, heart rate variability, hormones, and metabolism. Furthermore, multiple linear regression analysis allowed us to predict quantitative changes in physical work capacity150 with a standard error of 0.28 W/kg. This predictive model incorporated hemodynamic and Electroen cephalography parameters, achieving an adjusted R2 of 0.555. Conclusion. The directionality and magnitude of physical working capacity150 changes under the influence of balneofactors at the Truskavets Spa are determined by a complex constellation of initial physiological parameters, which forms the body’s reactivity. This finding has significant implications for personalizing balneotherapy treatments.
The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy
(Publishing Office of the University of Rzeszow, 2023-06) Popovych, Igor L.; Zukow, Walery A.; Fil, Vitalii M.; Kovalchuk, Halyna Y.; Bryndzia, Iryna V.; Voloshyn, Olena R.; Kopko, Iryna Y.; Lupak, Oksana M.; Skrobach, Taras B.
Introduction and aim. Drinking mineral waters are one of the environmental factors that affect the condition of the human body. Of particular interest are therapeutic waters of the Naftussya type, which contain autochthonous microbes and organic oil-like substances and can be considered as a kind of ecosystem. On the other hand, gastrointestinal tract also is an ecosystem that associates a resident microbiota and cells of various phenotypes lining the epithelial wall. We assumed that one of the mechanisms of the therapeutic effect of Naftussya water is the interaction of external and internal ecosystems. This article is the first in a series in support of the hypothesis. Material and methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The objects of study: leukocyturia, bacteriuria, components of microbiota, phagocytosis function of neutrophils, leukocytary adaptation index, plasma and urine electrolytes and nitrogenous metabolites. Results. The weekly use of bioactive Naftussya water from the Opaka deposit causes a favorable normalizing effect on the stool microbiota: it increases the reduced content of Bifidobacteria and Lactobacilli, instead it reduces the increased content of pathogenic strains of Escherichia coli, as well as Klebsiela and Proteus. Reduction of dysbacteriosis is accompanied by an increase in the reduced bactericidal capacity of blood neutrophils against E. coli and Staphylococcus aureus, and reduction of bacteriuria and leukocyturia. At the same time, the elevated level of creatinine in the plasma decreases, instead, the decreased levels of sodium and chloride increase. As expected, the daily diuresis and excretion of urea, creatinine, phosphates, calcium, magnesium and chloride increases, but not sodium and uric acid, the concentrations of which in the urine decrease. The described physiologically beneficial effects are interpreted as adaptogenic, which is confirmed by an increase in the reduced leukocyte adaptation index. Conclusion. The healing effect of Naftussya bioactive water is the result of the interaction of external and internal ecosystems. The next article will consider the role of the nervous and endocrine systems in this interaction.