Przeglądanie według Autor "Narla, Swetha Lakshmi"

Aktualnie wyświetlane 1 - 2 z 2

Atypical presentation of extra-skeletal Ewing’s sarcoma in a 57-year-old female – a case report
(Publishing Office of the University of Rzeszow, 2024-09) Nagalakshmi, Kumbha; Ramachandran, Nair Parvati; Narla, Swetha Lakshmi; Subramanyan, Annapurneswari; Parasuraman, Brundha Marimuthu
Introduction and aim. Malignant soft tissue tumors exhibiting similar histological and immunohistochemical characteristics to Ewing sarcoma of the bones are referred to as extra-skeletal Ewing sarcoma within the pathology research domain. These tumors fall under the broader classification of Ewing sarcoma family of tumors, which encompasses Ewing sarcoma of the bones, extra-skeletal Ewing sarcoma, and primitive neuroectodermal tumor, the latter demonstrating a more pronounced neural differentiation compared to Ewing sarcoma of the bone. Extra-skeletal Ewing sarcoma stands out as a rare, aggressive, and rapidly growing malignant soft tissue tumor characterized by a notable recurrence rate and a predilection for occurrence in males. The roots of recognizing extra-skeletal Ewing sarcoma trace back to 1975 when Angervall and Enzinger reported the inaugural case. This study aims to underscore the significance of recognizing diverse clinical presentations for precise diagnosis and effective patient care of Extra-skeletal Ewing sarcoma in an elderly patient. Case description. In the context of our pathology research, a noteworthy case involves a 57-year-old female presenting with a mass in the left iliac fossa. The diagnosis, established through a comprehensive approach involving Imaging, histopathological examination, immunohistochemistry, and molecular studies such as fluorescence in situ hybridization, confirms the nature of the tumor as extra-skeletal Ewing sarcoma. This case adds to the understanding and documentation of this distinct variant through a multi-modal investigative process. Conclusion. This case report contributes to the existing literature by shedding light on an atypical presentation of extra-skeletal Ewing sarcoma in an older patient. Understanding the varied clinical manifestations and incorporating advanced diagnostic techniques, such as fluorescence in situ hybridization and immunohistochemistry, is pivotal for accurate diagnosis and optimal patient management.
Secondary chondrosarcoma of the iliac bone in a young woman – a rare case report and review of the literature
(Rzeszów University Press, 2025-06) David, Therese; Narla, Swetha Lakshmi; Subramanyan, Annapurneswari; N., Kathiresan
Introduction and aim. Chondrosarcomas are malignant cartilage-forming tumors, with secondary cases rarely arising from osteochondromas. This report presents a case of secondary chondrosarcoma developing from an undiagnosed pelvic osteo chondroma in a young female, emphasizing the importance of early detection and timely intervention. Description of the case. A 28-year-old woman with hip and back pain underwent magnetic resonance imaging, revealing a le sion in the left iliacus muscle with sacroiliac extension. Biopsy confirmed a chondroid neoplasm, and positron emission topog raphy-computed tomography showed minimal metabolic activity. Due to the extensive soft tissue component and recurrence risk, wide local excision was performed. Histology confirmed well-differentiated secondary chondrosarcoma, WHO grade 1 arising from an undiagnosed pre-existing osteochondroma. Conclusion. The described case highlights the critical role of radiological and histopathological evaluation, timely surgical in tervention, and multidisciplinary management for optimal patient outcomes.