European Journal of Clinical and Experimental Medicine T.19, z. 2 (2021)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/6378

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Coronavirus disease 2019: ethical and epidemiological issues with clinical trials
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Tagaev, Tugolbai; Yethindra, Vityala; Zhumabekova, Altynai; Parihar, Yogesh; Narasimharaj, Alenur
Ethical issues surrounding false information about coronavirus disease 2019
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Yethindra, Vityala
A rare and overlooked cause of massive gastrointestinal bleeding: Distal duodenal GIST
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Düzenli, Tolga; Köseoğlu, Hüseyin; Erenler, Behice Hande
Introduction. Gastrointestinal stromal tumors (GIST) are tumors of mesenchymal origin which originate from the walls of gastrointestinal system (GIS) organs. Aim. In this case report we aim to discuss the clinical, labaratory and radiological presentation of distal duodenal GIST as a rare and overlooked cause of life-threatining GIS bleeding. Description of the case. A 76-year-old male patient was presented to the emergency department with massive gastrointestinal bleeding. Computerized tomography revealed a mass soft tissue density of 4x4cm at the level of the 3-4th segment of the duodenum. At the endoscopy, there was a deep ulcer in the proximal part of the 3rd segment of the duodenum with a diameter of 2 cm with a bleeding vessel protruding into the lumen. After endoscopic treatments, biopsies were taken from the edges of the ulcer. Histopathological examination revealed a sheet-like infiltration composed of mildly pleomorphic cells with oval-spindle nuclei and abundant eosinophilic cytoplasm in the duodenal lamina propria, as the patient was diagnosed of GIST. Conclusion. GIST and its clinical, labaratory and radiological presentation should be kept in mind in the approach to massive duodenal GIS bleeding.
Persistent hyperthyroidism in a patient after total thyroidectomy: the thyroid anatomy has implications for treatment
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Młodożeniec, Aleksandra; Gala-Błądzińska, Agnieszka
Introduction. Grave’s disease (GD) can be treated using three modalities: anti-thyroid medications, radioactive iodine therapy (RAI), or surgery. If surgery is selected, total thyroidectomy is the procedure of choice. Patients with hyperthyroidism frequently have an enlarged thyroid gland, occasionally with a pyramidal lobe. Aim. We point the usefulness of thyroid scintigraphy, which provides valuable information regarding the thyroid anatomy. Description of the case. The manuscript presents a case report of 43-year-old woman with unstable Grave’s disease, who underwent thyroidectomy and developed persistent hyperthyroidism postoperatively. She was referred by an endocrinologist to a nuclear medicine outpatient clinic for RAI therapy. I-iodide scintigraphy revealed two foci with excessive tracer accumulation. One of the foci in the middle of the neck corresponded to the pyramidal lobe. Conclusion. The thyroid anatomy anomalies can lead to unnecessary implications for treatment. Identifying the pyramidal lobe preoperatively and removing it from patients requiring total thyroidectomy may decrease the recurrence rate of hyperthyroidism. Thyroid scintigraphy is a useful diagnostic tool to visualize the pyramidal lobe.
Lian Gong for treatment of fibromyalgia – a case study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Ileck, Nathália Aparecida; de Azevedo, Marcus Vinícius Gonçalves Torres; Artioli, Dérrick Patrick; Bertolini, Gladson Ricardo Flor
Introduction. As a Complementary Integrative Practices (CIPs), Lian Gong has been increasingly used in the practice of Physiotherapy. Aim. This study aims to verify the effects of Lian Gong in a patient with fibromyalgia. Description of the case. In this case study the patient (one patient is evaluated) was diagnosed with fibromyalgia 29 years ago and sought care following discontent with previous treatments. Pain intensity was assessed with a visual analog scale (VAS), quality of life with SF-36, and the pressure pain threshold algometer (PPT). There were 16 visits with two weekly 60-minute sessions. When the patient was reevaluated, a Global Perception of Change (GPC) scale was added to assess general health. A folder was submitted to the patient for follow-up of exercises at home and asked to return after 4 weeks (follow-up period). Conclusion. The results indicate improvement in pain, functional capacity and general health. As a first therapy treatment, Lian Gong proved promising results in one case of fibromyalgia. The possible benefits when combined with other forms of care should be explored by clinical trials to expand knowledge of health benefit potential.
Naturally occurring photosensitizers and photodynamic therapy: laser or sun?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2015) Dynarowicz, Klaudia
Introduction. Our understanding of photodynamic therapy (PDT) is crucial for the applications of this treatment. In this physical phenomenon occurs light absorption by the applied photosensitizer, which results in its excitation to higher electron levels. After activation, a series of complex physicochemical processes take place in the tissues, Aim. The aim of this study was to describe the basic naturally occurring photosensitizers used in PDT techniques. This study clarified applications of photosensitizers. Material and methods. This study was used basic information about PDT reaction and the selective destruction of the tumor by photooxidation: a photosensitizer, a light source and oxygen. The papers reviewed here are based on Medline/Pub. Analysis of the literature. Photodynamic therapy is an innovative form of treatment. This method is not a commonly used therapeutic and therapeutic tool, but a supplement to many already tested and analyzed techniques. Thanks to continuous research, this method has a wider and wider range of applications in medicine. Conclusion. The data indicates increased number of papers regarding applications of PDT in medicine.
Natural properties of lycopene and its application in medicine
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Sowińska, Marta
Introduction. The subject of the article is a chemical compound belonging to the carotenoid family, i.e. lycopene. Aim. The aim of this study was to describe interest among scientists regarding lycopene due to its unique properties, general availability and potential for wide application in medicine. Material and methods. This article is a review in which the properties of lycopene, its chemical structure and sources (especially in the form of tomato fruits and its products), as well as its important role and importance in medicine, is presented. Analysis of the literature. Lycopene is an interesting compound with interesting properties. It may prove to be an important and readily available means of preventing and fighting cancer (especially prostate cancer, uterine cancer and breast cancer). Additionally, lycopene can counteract cardiovascular diseases that are common nowadays. Conclusion. The data indicates increased number of papers regarding applications of lycopene in medicine.
What’s new in airway secretions clearance for adults? A systematic review
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Kołodziej, Magdalena; Kochman, Maciej
Introduction. Airway clearance techniques are an essential part of routine respiratory physiotherapy, enabling bronchial secretion clearance—the mucus overproduction and retaining results in lung function deterioration and disrupts effective pulmonary rehabilitation. Several mucus clearance methods are included in the physiotherapy daily routine of patients with chronic lung conditions; nevertheless, new techniques and approaches are continuously developed. Aim. Thus, this systematic review summarizes novel airway clearance techniques applied in patients with chronic pulmonary conditions. Material and methods. The PubMed, Cochrane Library, and PEDro databases were searched from 2010 to 2021, and studies were selected based on eligibility criteria. Analysis of the literature. 101 patients from five studies describing four different techniques were included. Novel techniques were non-invasive ventilation, intrapulmonary percussive ventilation, trachea vibration, and PEP-sound wave combination. Significant improvements were noted for ventilation homogeneity (NIV), saturation (NIV), respiratory rate (IPV), and diffusion capacity (VL), whereas cardiovascular function and exercise endurance did not change significantly. Conclusion. The presented methods are considered to have similar effectiveness as well-known airway clearance techniques. However, the systematic use of presented methods in routine pulmonary rehabilitation must be preceded by in-depth investigation to provide no-bias results.
Assessment of the state of knowledge of bloodborne infections, occupational exposure and post-exposure prophylaxis and study of exposure to potentially infectious materials among students of selected medical faculties in Poland
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Pleśniak, Robert; Kocór, Sylwia; Kuźniar, Katarzyna; Oboz-Adaś, Antonina; Ziojła, Kinga
Introduction. Occupational exposure to potentially infectious material (PIM) is a serious problem for healthcare workers, including medical students. Aim. We assessed the state of knowledge about occupational exposure and frequency of exposure among students of selected medical faculties in Poland. Material and methods. Retrospective analysis with proprietary questionnaires. Results. Only 34.5% from 753 respondents correctly indicated bloodborne pathogens and 9.3% PIM. There were 84 reports of exposure, mostly during intravenous injections. 10.4% students claimed probable occupational exposure which was not reported. Most common reason for not reporting was fear of negative supervisor reaction. Conclusion. Student’s knowledge of this matter is poor. Significant percentage of students has never participated in occupational exposure training. Occupational exposure was experienced by surprisingly large number of students. Students are afraid to report the incidents. Additional education would be useful in reducing exposure risk.
Prevalence and predictive factors for exclusive breastfeeding in the first 6 months among mothers attending Primary Health Care Centers in Cairo, Egypt
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Emara, Zeinab Abdelhay; Amin, Ghada Essam Eldin; Hamid, Diaa Marzouk Abdel; Allam, Mohamed Farouk
Introduction. Although most organizations recommend breastfeeding for at least one year due to its well-known beneficial effects, the prevalence of exclusive breastfeeding in many developing countries was quite low. Aim. To identify prevalence and predictive factors affecting exclusive breastfeeding in Primary Healthcare (PHC) Centers in Cairo, Egypt. Material and methods. A cross-sectional study, among mothers attended first six months immunization sessions in three PHC Centers were selected via a convenient sample, A total sample of 180 mothers, 60 from each PHC Center, were subjected to an interview questionnaire. The questionnaire used was previously validated and pre-tested. Data collection took the period from April to August 2019. Comparison between exclusive and nonexclusive breastfeeding according to possible risk factors was done. Results. The frequency of breastfeeding among the participants was 90.6%; however the total exclusive breastfeeding frequency was only 39.4%. Our logistic regression model showed that exclusive breastfeeding decreased with progressive increase in infant’s age (OR 0.74), and mothers with good knowledge about proper practice of breastfeeding adhered more to exclusive breastfeeding (OR 2.51). Also, it showed that, during working hours, mothers who fed their infants other than breast milk adhered less to exclusive breastfeeding (OR 0.19). Conclusion. The prevalence of exclusive breastfeeding is quite low. The predictive factors for exclusive breastfeeding are, younger infant’s age, good knowledge of the mothers about proper practice of breastfeeding, and mothers insisting on breastfeeding during working hours.
Effects of bridging and V-sitting exercises on pain intensity and disability of patients with non-specific chronic low-back pain
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Ojoawo, Adesola O.; Igbemo, Abdullai A.; Adeyemi, Timothy; Olaogun, Matthew OB.
Introduction. Exercises are important in the management of non-specific chronic low-back pain (NSCLBP). Aim. The study compared the effects of bridging and V-sitting exercises on pain and disability of patients with NSCLBP. Material and methods. 34 patients with NSCLBP recruited for the study were allocated into V-sitting (VSG) and Bridging Exercise group (BEG) equally. Participants in VSG and BEG groups performed V-sitting and bridging exercises respectively for 10 seconds, three times in a week for three weeks under a supervision of one of the authors. Each participants underwent ten sessions per a treatment regimen. Pain intensity and disability were assessed at the pre-intervention, second and third weeks using verbal rating scale and Rolland Morris Low Back Pain Disability Questionnaire prospectively. Data were analyzed using descriptive and inferential statistics, alpha level was set at 0.05 Results. There was a significant reduction in the third week (P < 0.001) in both VSG and BEG group of pain intensity and disability comparing the pre intervention, second and third week values. There was a significant reduction in the 3rd week VSG’s pain intensity (F=27.34 P<0.001) and disability (F=14.96, P<0.001) compared with BEG. Conclusion. V-sitting and bridging exercises were effective in management of patients with NSCLP, but V-sitting seems more effective.
A prospective, interventional clinical study to evaluate the safety and efficacy of Liv.52 DS in the management of non-alcoholic fatty liver disease
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2015) Siregar, Gontar; Paramesh, Rangesh; Kumawat, Rajesh; Palaniyamma, D; Srikrishna, HA
Introduction. Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver due to causes other than alcohol use. Aim. To evaluate the clinical efficacy and safety of Liv.52 DS tablets in the management of NAFLD. Material and methods. Prospective, interventional clinical study conducted on 60 patients of both sex, aged between 18-65 years, confirmed with NAFLD from clinical examination, laboratory test, ultrasound findings and those willing to give informed consent. All patients received Liv.52 DS at a dose of 2 tablets twice daily for 2 months. All patients were evaluated at baseline, end of 1st month, and end of 2nd month for liver function tests, hepatomegaly by ultrasound, NAFLD Fibrosis Score, lipid profile, hematology and biochemical investigations. Results. Study data was analyzed with GraphPad Prism Software Version 6.07. Data of those patients who completed the study was considered for analysis. Significant improvement in hepatomegaly, liver enzymes was observed. NAFLD fibrosis score revealed no progression of liver fibrosis due to NAFLD during the study period. No abnormal lab values were recorded and there were no adverse events reported during the study. Conclusion. Study concludes that Liv.52 DS is safe and beneficial in individuals suffering from NAFLD.
A novel method of immunomodulation of endothelial cells using Streptococcus pyogenes and its lysate
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Arokiaraj, Mark Christopher; Wilson, Jarad
Introduction. Coronary artery diseases and autoimmune disorders are common in clinical practice. Aim. In this study, Streptococcus pyogenes and its lysate were studied to modify the endothelial function. Material and methods. HUVEC cells were seeded in the cell culture, and Streptococcus pyogenes were added to the cell culture, and the supernatant was studied for the secreted proteins. In the second phase, the bacterial lysate was synthesized, and the lysate was added to cell culture and studied. Results. When S. pyogenes alone was added to culture, E Cadherin, Angiostatin, EpCAM and PDGF-AB were some of the biomarkers elevated significantly. HCC1, IGFBP2 and TIMP were some of the biomarkers which showed a reduction. When the lysate was added, the cell-culture was maintained for a longer time, and it showed the synthesis of immune regulatory cytokines. Heatmap analysis showed a significant number of proteins/cytokines concerning the immune/pathways, and toll-like receptors superfamily were modified. BLC, IL 17, BMP 7, PARC, Contactin2, IL 10 Rb, NAP 2 (CXCL 7), Eotaxin 2 were maximally increased. By principal component analysis, the results observed were significant. Conclusion. There is potential for a novel method of immunomodulation of the endothelial cells, which have pleiotropic functions, using S. pyogenes and its lysates.
Low-level laser therapy on the rat’s gastrocnemius morphometry submitted to a rheumatoid arthritis model
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2021) Marin, Estéfani; Fuse, Jacqueline Lumy; Lopes, Larissa Pereira; Neves, Morgana; da Silva Leal, Taciane Stein; de Fátima Chasko Ribeiro, Lucinéia; Bertolini, Gladson Ricardo Flor
Introduction. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease of unknown origin, mainly affecting synovial joints and related structures, including the adjacent musculature, generating great disability and reduction in quality of life. Aim. This study was designed to investigate the effect of low-level laser therapy (LLLT) on gastrocnemius of Wistar rats subjected to an experimental model of RA. Material and methods. Forty male Wistar rats were used, separated into: acute and chronic, being subdivided into Control Group (CG): without intervention, Lesion Group (LG): submitted to lesion, Laser Control Group (LCG): without lesion and with treatment, and Laser Lesion Group (LLG): submitted to lesion and LLLT. The treatment with LLLT occurred in four points of the right knee, wavelength of 660 nm, energy density of 5 J/cm2, energy per point of 0.003 J. Morphometric analysis was performed using a 40x magnification photomicrograph and analyzed using the Image-Pro-Plus 6.0 program. Results. As result of the acute group there was a difference only for muscle mass, being higher in CG. For the chronic group there was significant difference for cross-sectional area, larger and smaller diameter, again with the control group obtaining higher values than the others, for the number of nuclei LG was lower than CG and LCG, but LLG was not different from any of them. Conclusion. It is concluded that treatment with LLLT was not very effective in reversing the harmful effects of RA on the gastrocnemius muscle.

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