European Journal of Clinical and Experimental Medicine T.20, z. 4 (2022)

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https://repozytorium.ur.edu.pl/handle/item/8428

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  • Obrazek miniatury
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    Fabry disease related nephropathy – case family report and literature review
    (Publishing Office of the University of Rzeszow, 2022-12) Król, Nikola; Trąd, Szymon; Milian-Ciesielska, Katarzyna; Gala-Błądzińska, Agnieszka
    Introduction and aim. Fabry disease (FD) is a ultrarare storage disorder which causes irreversible damage to the brain, heart, and kidneys in young patients. The aim of our study was to draw clinician’s attention to the need of considering FD in the differential diagnosis of kidney disorders. Description of the case. We present the case of a 45-year-old man who has been misdiagnosed for several years with arterial hypertension with organ complications. He was referred to the nephrological ward due to chronic advanced kidney disease of unclear etiology. After 2 months of thorough differential diagnostics, based on the clinical course (past stroke, membranoproliferative glomerulonephritis (MPGN), left ventricular hypertrophy, paroxysmal limb pain) and conducted genetic examination, FD was confirmed. Then, screening tests were performed among the patient’s family members, confirming the presence of the same mutation as in our patient in 4 women of which in 3 were diagnosed cardio-renal syndrome. The authors of other studies report glycolipid deposits in the kidney cells on a needle biopsy, usefulness assess podocyturia, globotriaosylceramide protein in the urine and renal parapelvic cysts in an ultrasound examination in diagnostic FD nephropathy. Conclusions. This is the first case report to describe membranoproliferative glomerulonephritis in a patient suffering from FD. In patients with FD and the same genotype, kidney damage has a different phenotype.
  • Obrazek miniatury
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    Favre-Racouchot syndrome and chronic obstructive pulmonary disease – a common link
    (Publishing Office of the University of Rzeszow, 2022-12) Shamsi Mohd, Imran; Dawar, Sachet; Shaafie Harris, Ishtiyaq; Chaudhry, Arun
    Introduction and aim. Favre-Racouchot syndrome though mostly reported in Caucasian men (with an estimated prevalence of 6% in adults older than 50 years), cases have been reported in dark-skinned population including Indians, albeit rarely. It is characterized by large open and closed comedones along with epidermal cysts over the nose, cheeks, temples, forehead and periorbital areas. The association of this condition with chronic heavy smoking is what it makes compelling. Description of the case report. We report a case of elderly male, chronic heavy smoker who was diagnosed as a case of chronic obstructive pulmonary disease (COPD) as per standard guidelines. He presented with multiple nodulo-cystic lesions and had undergone a skin biopsy. Histomorphology features were consistent with Favre-Racouchot syndrome. Conclusion. Early identification of this skin condition in mildly symptomatic and asymptomatic smokers may help clinicians to forewarn the patients regarding development of chronic obstructive pulmonary disease (COPD).
  • Obrazek miniatury
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    The impact of physical activity on the cognitive fitness of the elderly – a review
    (Publishing Office of the University of Rzeszow, 2022-12) Marszałek, Anna; Kasperczyk, Tadeusz; Walaszek, Robert; Burdacka, Katarzyna
    Introduction and aim. The issues of humans’ ageing are more and more frequently addressed in the relevant literature. Most commonly, people follow three ageing trajectories: a normal one, disease-affected one, and a healthy one. The purpose of this article is to present a relationship between physical activity and occurrence of cognitive function impairment in the elderly. Material and methods. This paper is a narrative review. Based on a literature search, various forms of physical activity are presented, as well as the effects of physical activity on mitigation of cognitive disorders in the elderly. The following databases were used: Web of Science, PubMed, Google Scholar. Analysis of the literature. One of the most important factors that promote healthy ageing is regular physical activity. Many studies and publications have addressed this issue. The relationships between physical activity and cognitive fitness have been less studied. Conclusion. The results of the studies presented in this article may form the basis for more in-depth analyses and, in a longterm perspective, for the development of optimal preventive and therapeutic strategies using broadly understood physical activity to maintain cognitive fitness of the elderly.
  • Obrazek miniatury
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    Obesity-diabetes-endocrinopathy – the metabolic connection
    (Publishing Office of the University of Rzeszow, 2022-12) Kozakowski, Jarosław; Dudek, Piotr; Zgliczyński, Wojciech
    Introduction and aim. The article outlines the mechanisms of interrelationships between obesity, type 2 diabetes, and certain disorders of the endocrine system. The paper explains how insulin resistance develops, which is a key link between obesity and several related disorders, how hypercortisolemia leads to the development of obesity and glucose intolerance, why thyroid dysfunctions are bidirectionally associated with metabolic disturbances, in what way excessive body weight leads to the hypogonadism in men, or how menopause promotes the development of abdominal obesity, carbohydrate intolerance and, in some cases type 2 diabetes. Material and methods. Scientific articles were reviewed by searching for information using the online database with scientific articles, including PubMed, Google Scholar and other available scientific databases. Analysis of the literature. The huge prevalence of obesity, diabetes, and hormonal disorders (e.g., autoimmune thyroid disease, female and male hypogonadism) over the contemporary world together with the serious health consequences of these conditions makes up a specific triangle of metabolic connections, increasingly absorbing the human, organizational and financial resources of health systems. Conclusion. Recognizing the relationship between the components of this triangle and understanding the risks arising from this phenomenon may allow to effectively reduce its impact on our health.
  • Obrazek miniatury
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    Correlation between rheumatoid arthritis and periodontitis
    (Publishing Office of the University of Rzeszow, 2022-12) Zielińska, Anna; Tabarkiewicz, Jacek
    Introduction and aim. The association between periodontitis (PD) and rheumatoid arthritis (RA) has been analyzed and described in literature. Periodontal pathogens, such as “Porphyromonas gingivalis” and “Aggregatibacter actinomycetemcomitans” are pointed as the common factors for both diseases. In this work we demonstrate that treatment of dental and oral diseases is an unconditional requirement for patients with RA. Material and methods. PubMed was searched with the keyword “rheumatoid arthritis” and “periodontitis” from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included in the review. Analysis of the literature. The above mentioned pathogens exhibit multiple mechanisms that disturb immune and inflammatory responses of the human organism. Those mechanisms lead to the periodontal disease (PD) that may activate the systematic reactions which in turn lead to intensification of systematic diseases such as rheumatoid arthritis (RA). P. gingivalis has the ability to expresses PAD enzyme (peptidylarginine deiminase) and activates the citrullization process. Moreover, the bacterium produces gingipain cysteine proteinases, which degrade the mechanisms of immunological system. The latter pathogen, A. actinomycetemcomitans, expresses hypercitrullization in neutrophils. Conclusion. Both pathogens influence inflammatory response of the organism, through the common pro-inflammatory mediators for periodontitis and rheumatoid arthritis, intensify the clinical manifestations of both diseases.