Djallalluddin, DjallalluddinUtomo, Anggarda KristiantiWanahari, Tenri Ashari2025-10-012025-10-012025-09European Journal of Clinical and Experimental Medicine T. 23, z. 3 (2025), s. 731–7412544-1361https://repozytorium.ur.edu.pl/handle/item/11834Introduction and aim. COVID-19, caused by SARS-CoV-2, significantly affects the cardiovascular system beyond its respiratory manifestations. This review examines the intricate relationship between COVID-19 and cardiovascular complications, focusing on cardiac arrhythmias and their underlying pathophysiology. Material and methods. A comprehensive literature search was conducted in PubMed and Google Scholar from its inception to December 2024, including peer-reviewed articles published in English. Analysis of literature. In COVID-19, a spectrum of cardiovascular complications is observed, including acute myocardial infarction, arrhythmias, myocarditis, venous thromboembolism, and heart failure/cardiac shock. The pathophysiology of cardiovascular damage in COVID-19 involves multiple mechanisms, primarily including direct viral cardiotoxicity, systemic inflammation, and hypercoagulability. Arrhythmias are a common cardiac complication in COVID-19, encompassing a range of disturbances, from bradycardia to ventricular fibrillation. The mechanisms underlying arrhythmias in COVID-19 are multifaceted, including direct viral injury to cardiomyocytes, hypoxia, systemic inflammation, hyperthermia, autonomic imbalance, electrolyte imbalances, side effects of medications, and drug-drug interactions. Conclusion. Understanding the complex interplay of these factors is crucial for the early diagnosis and appropriate management of cardiac complications in patients with COVID-19. To mitigate cardiovascular morbidity and mortality in individuals with COVID-19, cardiovascular monitoring and the development of targeted therapeutic strategies are highly recommended.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/arrhythmiascardiovascular diseasescoronavirusCOVID-19pathophysiologyarticle10.15584/ejcem.2025.3.1