Oscanoa, Teodoro J.Cieza-Macedo, EdwinRomero-Ortuno, Roman2026-02-132026-02-132025-12European Journal of Clinical and Experimental Medicine T. 23, z. 4 (2025), s. 978–9832544-1361https://repozytorium.ur.edu.pl/handle/item/12202Ethical approval for this study was obtained from the Institutional Research Ethics Committee of Almenara Hospital in Lima, Peru (approval No. 80-CIEI-OI-yD-GRPA-ESSALUD-2023; March 27, 2023). All data was managed in accordance with national ethical regulations.Introduction and aim. Handgrip strength (HGS) serves as a key indicator of muscle performance and may reflect cognitive status in older cancer patients. We examined whether handgrip strength was associated with cognitive function in this group of patients. Material and methods. For this study, a cross-sectional design was used, analyzing data from patients aged 60 years and older diagnosed with cancer, collected through Comprehensive Geriatric Assessments (CGAs). The information included demographics, HGS levels, and Mini-Mental State Examination (MMSE) scores. Results. Among 352 participants (average age 75.7 years), HGS showed a moderate positive correlation with cognitive function, stronger in females (r=0.36, p<0.001) than in men (r=0.22, p=0.005). Each 1 kg increase in HGS was associated with a 0.29-point increase in MMSE scores in women and 0.13 points in males. Conclusion. Higher HGS appears to better cognitive outcomes in older adults with cancer. As muscle strength is potentially modifiable, future research should explore whether HGS-targeted interventions could preserve or enhance cognitive health. Implementing regular handgrip strength assessments in geriatric oncology could help to detect patients who are vulnerable to cognitive decline.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/cancercognitionaginghandgrip strengthsarcopeniaarticle10.15584/ejcem.2025.4.21