Rahamon, Sheu KadiriGaniyu, ArinolaCharles-Davies, Mabel AyebatonyoAkinlade, Kehinde SolaOlaniyi, John AyodeleFasanmade, Adesoji AdedipeOyewole, Oyediran EmmanuelOwolabi, Mayowa OjoAdebusuyi, Jane RoliHassan, Olufunke OlayemiAjobo, Muhammed BabatundeAdigun, KehindeEbesunun, Maria OnomaghuanPopoola, Omolara OlutosinOmiyale, WemimoAgbedana, Emmanuel Oluyemi2022-04-072022-04-072021European Journal of Clinical and Experimental Medicine T. 19, z. 4 (2021), s. 306–3122544-2406http://repozytorium.ur.edu.pl/handle/item/7580Results from this study were presented at the 11th Congress of the Federation of African Immunological Societies (FAIS).Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.polAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowehttp://creativecommons.org/licenses/by-nc-nd/4.0/inflammationmetabolic syndromevitamin Darticle10.15584/ejcem.2021.4.32544-1361