European Journal of Clinical and Experimental Medicine T.20, z. 1 (2022)https://repozytorium.ur.edu.pl/handle/item/7592https://repozytorium.ur.edu.pl/retrieve/96dc5661-821c-46d1-b52c-c94ac65ff356/2024-03-29T12:59:06Z2024-03-29T12:59:06Z181A benign entity – cerebral multinodular and vacuolating neuronal tumorKış, NaciyeErok, BerrinKılıç, HarunÖnder, Hakanhttps://repozytorium.ur.edu.pl/handle/item/76112022-11-29T15:03:21Z2022-01-01T00:00:00Zdc.title: A benign entity – cerebral multinodular and vacuolating neuronal tumor
dc.contributor.author: Kış, Naciye; Erok, Berrin; Kılıç, Harun; Önder, Hakan
dc.description.abstract: Introduction and aim. Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare benign, mixed glial/ neuronal lesion which has been included in the recent (2016) World Health Organization (WHO) Classification of the central nervous system tumors.Most of the reported cases are remarkable with adult onset seizure in the literature.They can also be found incidentally in nonepilepsy patients with or without headache We aimed to present this unique entity with its typical magnetic resonance imaging (MRI) features. Description of the case. A 21-year old man presented with complaint of headache that increased in frequency within the last few months.No relevant seizure or any other signs of note.He was diagnosed with MVNT by imaging andstarted to be followed- up.The repeat MRI 6 months later showed no interval changes. Conclusion. Clinicians should be aware of that it is a do not touch lesion in asymptomatic patients with no need for biopsy or surgery and follow up imaging is sufficient when presented with the typical MRI manifestations. Surgical resection may be required for seizure control and was reported in few cases with no tumoral regrowth in the literature.
2022-01-01T00:00:00ZNon-ketotic hyperglycemia and diabetic striatopathy – a rare presentation with hemichorea-hemiballismusErok, BerrinKeklikoğlu, Taha OğuzKış, NaciyeÖnder, Hakanhttps://repozytorium.ur.edu.pl/handle/item/76102022-11-29T16:11:06Z2022-01-01T00:00:00Zdc.title: Non-ketotic hyperglycemia and diabetic striatopathy – a rare presentation with hemichorea-hemiballismus
dc.contributor.author: Erok, Berrin; Keklikoğlu, Taha Oğuz; Kış, Naciye; Önder, Hakan
dc.description.abstract: Introduction and aim. Non-ketotic hyperglycemia (NKHG), also known as hyperosmolar hyperglycemic state (HHS) is a serious metabolic complication of diabetes mellitus (DM).The mortality rate can be up to 20% and this is much more higher than that of diabetic ketoacidosis (DKA). It is usually precipitated by an event such as pulmonary/urinary infection, myocardial infarction (MI) or stroke. In this state of metabolic derangements, central nervous system (CNS) manifestations including altered mental status with or without focal neurological deficits are prominent clinical presentations. On the other hand, HHS may also be complicated with various other CNS events. Herein, a quite rare presentation of HHS with hemichorea ‒ hemiballismus in a 71 year old female patient with type 2 DM is presented. Description of the case. A 71-year-old female patient type 2 DM presented to our emergency department with progressive involuntary movements on the right upper and lower extremities accompanied by semiconsciousness during the last 24 hours. On neurological examination, cranial nerves and cerebellar signs were found to be normal, as the deep tendon reflexes. However, involuntary non-rhythmic writhing movements at rest were present on her right sided extremities. The fingerstick evaluation showed marked hyperglycemia (HG). The laboratory findings were characterized with high blood glucose level without obvious acidosis compatible with HHS. In urine analysis, glucosuria without significant ketonuria was detected. On head CT, subtle hyperdensity was noted in the left neostriatal regions without any mass effect or perilesional edema, compatible with left sided diabetic striatopathy (DS). Conclusion. Diabetic striatopathy is a quite rare presentation of HHS with hemichorea – hemiballismus. The characteristic computed tomograhy (CT) findings of associated striatopathy should be differentiated from vascular lesions that may also present with unilateral findings in the course of HHS and should not be overlooked in diabetic patients to recognise the ongoing HHS before the coma precedes.
2022-01-01T00:00:00ZPaired box 8 in organogenesis and oncogenesis – a reviewSzpunar, Magdalenahttps://repozytorium.ur.edu.pl/handle/item/76092022-11-29T15:21:13Z2022-01-01T00:00:00Zdc.title: Paired box 8 in organogenesis and oncogenesis – a review
dc.contributor.author: Szpunar, Magdalena
dc.description.abstract: Introduction and aim. Paired box 8 (PAX-8) is a specific transcription factor known as a protein product gene that plays an essential role in organogenesis and oncogenesis. The aim of this paper was to discuss structure and function of PAX-8. The aim of this study is to determine the utility of PAX-8 in cytology effusions with metastatic tumor. Material and methods. This article is a review done in regards to discuss the role knowledge on PAX-8 especially in oncogenesis and organogenesis. Analysis of the literature. Current information about PAX-8 is presented. Conclusion. The PAX family of genes plays an important role in the formation of tissues and organs during embryonic development and in maintaining the proper functioning of certain cells after birth.
2022-01-01T00:00:00ZCurrent research opportunities for potential phytotherapeutic agents for the treatment of pathologies of the female reproductive systemSokolik, Olena PetrivnaProzorova, Galina Olexandrivnahttps://repozytorium.ur.edu.pl/handle/item/76082022-11-29T15:13:54Z2022-01-01T00:00:00Zdc.title: Current research opportunities for potential phytotherapeutic agents for the treatment of pathologies of the female reproductive system
dc.contributor.author: Sokolik, Olena Petrivna; Prozorova, Galina Olexandrivna
dc.description.abstract: Introduction and aim. Herbal medicine is prescribed for various disorders of the menstrual cycle (uterine bleeding, dysmenorrhea), for the treatment of premenstrual and climacteric syndromes, inflammatory diseases of the genital organs, mastopathy and mastalgia and other pathological conditions. The aim of the study is to analysis and generalization of data from professional literature and own experience in the treatment of patients with pathologies of the female reproductive system by phytotherapeutic methods, taking into account the influence of medicinal plants on various links in the pathogenesis of the disease, as well as making recommendations for improvement and prospects for the use of phytotherapy in the treatment of this pathology. Material and methods. To make an analysis of literary sources of domestic and foreign authors about usage of medicinal plants for the treatment of pathologies of the female reproductive system. Analysis of the literature. In the treatment of primary (spasmodic) dysmenorrhea, herbal remedies with an antispasmodic, analgesic, hormone-mimetic effects are prescribed. It can be Chamomile (Matricaria chamomilla L.), Achillea millefolium, commonly known as yarrow, Viburnum, Shepherd’s purse (Capsella bursa-pastoris), Greater celandine, Atropa belladonna, Hyoscyamus niger, commonly known as henbane, black henbane, or stinking nightshade and Abraham’s tree. Many plants have bactericidal activity, and this property is used in the treatment of inflammatory diseases of the mucous membranes and skin. Such properties are possessed by flowers of Chamomile (Matricaria chamomilla L.), Calendula officinalis, infusion of Medicinal sage (Salvia officinalis L.). For the treatment of functional hyperprolactinemia phytopreparations are also successfully used. It is known that the medicinal plant Vitex agnus castus has dopaminergic properties, selectively blocking prolactin synthesis, and reduces follicle stimulating hormone levels. Strychnos ignatia, Caulophyllum thalictroides, European cyclamen, Lilium tigrinum, Iris versicolor provide a complex effect on the female body, effectively reduces the level of prolactin and the severity of mastalgia, which is confirmed not only by clinical data, but also by mammography data in fibrocystic breast disease. For the treatment of climacteric syndrome, a large number of medicinal plants are used, in particular, the most popular is the Cimicifuga racemose. Conclusion. The effectiveness of phytotherapeutic drugs has been verified by many clinical trials. Modern phytotherapy is becoming more widespread in clinical practice, as an alternative to drug treatment.
2022-01-01T00:00:00ZNanomedicine – a reviewDynarowicz, KlaudiaAebisher, Davidhttps://repozytorium.ur.edu.pl/handle/item/76072022-11-29T15:16:31Z2022-01-01T00:00:00Zdc.title: Nanomedicine – a review
dc.contributor.author: Dynarowicz, Klaudia; Aebisher, David
dc.description.abstract: Introduction and aim. Nanomedicine is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. This department deals with everything on the nano scale, i.e. on the level of individual atoms and molecules. This work presents the nano scale, i.e. on the level of individual atoms and molecules. Nanotechnology is currently one of the most popular and dynamically developing fields, not only in electronics, but above all in pharmacy and medicine. Material and methods. In this article a narrative review regarding nanomedicine. Analysis of the literature. The desire to summarize information about nanomedicine application of singlet oxygen is presented. Nanotechnology is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. Conclusion. The use of nanostructures is currently very efficient. The areas in which the potential of nanoparticles is constantly researched and confirmed by numerous articles are: radio- and chemotherapy, cancer diagnostics and imaging medicine (MRI and fluorescence imaging).
2022-01-01T00:00:00ZBreast hypertrophy, forward head posture, neck and shoulder pain-related disabilities and selected anthropometrics variables of female undergraduate studentsAkodu, Ashiyat KehindeOti, Temiloluwa GraceLawal, Abdulrazzaq Oluwagbemigahttps://repozytorium.ur.edu.pl/handle/item/76062022-11-29T16:05:18Z2022-01-01T00:00:00Zdc.title: Breast hypertrophy, forward head posture, neck and shoulder pain-related disabilities and selected anthropometrics variables of female undergraduate students
dc.contributor.author: Akodu, Ashiyat Kehinde; Oti, Temiloluwa Grace; Lawal, Abdulrazzaq Oluwagbemiga
dc.description.abstract: Introduction and aim. Large breast sizes frequently contribute to women presenting with severe pain symptoms. This study determined the association between breast hypertrophy, forward head posture (FHP), neck and shoulder pain related disabilities and selected anthropometric variables of female undergraduate students of College of Medicine, University of Lagos. Material and methods. A cross-sectional analytical study was conducted among 89 female undergraduate students (mean age = 21.45±1.29 years) with breast hypertrophy (cup size D and above). Breast cup sizes, neck and shoulder pain related disabilities, forward head posture were measured using a measuring tape, neck pain disability scale, shoulder pain disability index and craniovertebral angle (CVA) using photography method. Results. The prevalence of forward head posture among the participants was 43(48.3%). Twenty-eight (31.3%) participants had a “DD” cup size, twenty-six (29.2%) participants had a “DDD” cup size. Sixty-five (73%) of the participants had neck pain related disabilities and 10 (11.2%) of the participants had shoulder pain related disabilities. There was association among weight, forward head posture (p=0.027) and breast hypertrophy (p=0.016). Conclusion. Neck, shoulder pain related disabilities, and forward head posture is prevalent among undergraduates with breast hypertrophy and weight has an influence on forward posture and breast hypertrophy.
2022-01-01T00:00:00ZContribution of bread and biscuits to vitamin A daily requirement of preschool children in Lagos State, NigeriaUchendu, Florence N.Oyewole, Oyediran Emmanuel
https://repozytorium.ur.edu.pl/handle/item/76052023-05-24T06:48:10Z2022-01-01T00:00:00Zdc.title: Contribution of bread and biscuits to vitamin A daily requirement of preschool children in Lagos State, Nigeria
dc.contributor.author: Uchendu, Florence N.; Oyewole, Oyediran Emmanuel
dc.description.abstract: Introduction and aim. Vitamin-A-deficiency is a public health problem among preschool children of Nigeria. Study determined the contribution of bread and biscuits to vitamin A-daily-requirement of preschool children in Lagos-State, Nigeria. Material and methods. A community-based-study using a cross-sectional-design with analytical component was carried out from 2013-2015. Multi-stage-sampling-technique was used to select mothers of preschool-children (n=1599) in 5 Local-Government- Areas of Lagos. Respondents’ socio-demographic information and samples consumption-pattern were collected using validated, food-frequency-questionnaire/dietary recall. Retinyl palmitate content of randomly selected commonly-consumed brands of oven-fresh-bread stored for 5-days and biscuits (30- to 60-days) at prevailing outdoor-market-temperatures were analysed using High-Performance-Liquid-Chromatography. Contribution to preschool children’s vitamin A-daily-requirements were determined. Data were analysed using Student’s t-test and ANOVA at p<0.05. Results. Mean age of preschool children was 31.44±5.28 months. Mean intakes of samples were bread (117.6 ±15.9 g/d) and biscuits (59.8±27.9 g/d). Range of contribution to vitamin-A-daily-requirement of preschool-children was 0-178.4 %. Samples contribution to vitamin A-daily-requirement of pre-school-children were oven-fresh bread (68.3 %); 5 days bread (20.7%); 30-days biscuits (25.0%) and 60-days biscuits (6.8%). Overall contribution to vitamin A-daily-requirement were bread (51.4%) and biscuits (22.4%). Statistically significant difference existed between samples contribution and vitamin-A-daily-requirement of preschool children. Conclusion. Bread and biscuits samples contributed significantly to the vitamin-A-daily-requirement of preschool children.
2022-01-01T00:00:00ZAssessment of the effect of size of the umbilical ring on the risk of umbilical hernia complication in childrenEmeka, Chukwubuike KevinChikaodili, Eze Thaddeushttps://repozytorium.ur.edu.pl/handle/item/76042022-11-29T16:13:27Z2022-01-01T00:00:00Zdc.title: Assessment of the effect of size of the umbilical ring on the risk of umbilical hernia complication in children
dc.contributor.author: Emeka, Chukwubuike Kevin; Chikaodili, Eze Thaddeus
dc.description.abstract: Introduction and aim. Assessment of risk of complications in umbilical hernia is important. The aim of this study was to evaluate the effect of size of the umbilical ring on the risk of complication occurring in umbilical hernia. Material and methods. This was a prospective study of children who had umbilical hernia repair for symptomatic umbilical hernia. Using Vernier caliper, the umbilical ring diameter (URD) was measured at surgery and the patients were divided into 2 groups. Group A had URD of less than of 15 millimeter (mm) and group B patients had URD of 15 mm and above. The 2 groups were compared. Results. Thirty two cases were evaluated. Their mean age was 42 months. All the patients had umbilical pain. Twenty six (81.3%) patients had URD of less than 15 mm (group A) whereas 6 (18.7%) patients had URD of greater or equal to 15 mm (group B). Group A patients had a mean URD of 12.1±3.4 mm whereas group B patients had a mean URD of 30.5±5.0 mm (p=0.001). Conclusion. Children who have URD of less than 15 mm are at a higher risk of developing umbilical hernia complications.
2022-01-01T00:00:00ZOxidative and nitrosative stress in patients with meningitisNamiduru, Emine SiberNamiduru, MustafaKaraoğlan, İlkayKoçak, Kübrahttps://repozytorium.ur.edu.pl/handle/item/76032022-11-29T17:19:04Z2022-01-01T00:00:00Zdc.title: Oxidative and nitrosative stress in patients with meningitis
dc.contributor.author: Namiduru, Emine Siber; Namiduru, Mustafa; Karaoğlan, İlkay; Koçak, Kübra
dc.description.abstract: Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TAS) and total antioxidant status (TOS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.
2022-01-01T00:00:00ZMuscle energy technique and static stretching in patients with mechanical neck pain – a randomized studyOjoawo, Adesola O.Ige, BlessingKunnuji, Kanodehttps://repozytorium.ur.edu.pl/handle/item/76012023-05-23T13:07:06Z2022-01-01T00:00:00Zdc.title: Muscle energy technique and static stretching in patients with mechanical neck pain – a randomized study
dc.contributor.author: Ojoawo, Adesola O.; Ige, Blessing; Kunnuji, Kanode
dc.description.abstract: Introduction and aim. Neck pain is becoming increasingly common throughout the world with a considerable impact on individuals. This study compared the effects of muscle energy techniques (MET) and static stretching (SS) on pain intensity and functional disability of patient with mechanical neck pain. Material and methods. Fifty subjects with mechanical neck pain recruited were randomly allocated into MET and SS groups equally. Subjects in MET received MET protocol, and SS groups were treated with SS; both groups had treatment twice a week for six weeks. Pain intensity and functional disability at baseline, 3rd and 6th week of treatment were measured. Descriptive and Inferential statistics were used to analyze the data. Alpha level was set at <0.05. Results. There were 12 males and 13 females for MET with age ranged between 31–53 years mean was 42.41± 7.35 years and 11 males and 14 females in SS group with age range 22–60 years and mean age of 42.91±10.44 years. There was a significant reduction in pain intensity and disability in MET’s and SS group (p<0.05) when pre-treatment, 3rd week and 6th week treatment were compared. Pain intensity was lower at SS than MET while functional disability was lower in MET than SS p<0.05 at 6th week Conclusion. MET reduces ND more than SS and SS reduces pain intensity better MET.
2022-01-01T00:00:00Z